Greehey CCRI News & Events Archive

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RNA Biology: microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest

May 6, 2015

Zhenze ZhaoGreehey Children’s Cancer Research Institute; ,Xiuye Ma,Derek Sung,Monica Li,Adam Kosti,Gregory Lin,Yidong Chen,Alexander Pertsemlidis,Tzu-Hung Hsiao &Liqin Du Abstract microRNA-449a (miR-449a) has been identified to function as a tumor …


BMC Genomics: HEPeak: an HMM-based exome peak-finding package for RNA epigenome sequencing data

April 21, 2015

Xiaodong Cui, Jia Meng, Manjeet K Rao, Yidong Chen & Yufei Huang Abstract Background Methylated RNA Immunoprecipitation combined with RNA sequencing (MeRIP-seq) is revolutionizing the de novo study of RNA epigenomics at a higher resolution. However …


BMC Genomics: Parameter optimization for constructing competing endogenous RNA regulatory network in glioblastoma multiforme and other cancers

April 21, 2015

Yu-Chiao Chiu, Tzu-Hung Hsiao, Yidong Chen & Eric Y Chuang Abstract Background In addition to direct targeting and repressing mRNAs, recent studies reported that microRNAs (miRNAs) can bridge up an alternative layer of post-transcriptional gene reg …


Fitoterapia: Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer

April 1, 2015

Marco Masi 1, Liliya V Frolova 2, Xiaojie Yu 3, Véronique Mathieu 4, Alessio Cimmino 1, Annelise De Carvalho 4, Robert Kiss 4, Snezna Rogelj 2, Alexander Pertsemlidis 3, Alexander Kornienko 5, Antonio Evidente 6 Abstract A new alkaloid, belonging to th …


New Phytologist: Genome scans reveal candidate domestication and improvement genes in cultivated sunflower, as well as post-domestication introgression with wild relatives

April 1, 2015

Gregory J Baute 1, Nolan C Kane, Christopher J Grassa, Zhao Lai, Loren H Rieseberg Abstract The development of modern crops typically involves both selection and hybridization, but to date, most studies have focused on the former. In the present study, …


IEEE Xplore: MeTDiff: A Novel Differential RNA Methylation Analysis for MeRIP-Seq Data

March 2, 2015

Lin Zhang; Jia Meng; Manjeet K. Rao; Yidong Chen; Yufei Huang Abstract: N6-Methyladenosine (m6A) transcriptome methylation is an exciting new research area that just captures the attention of the research community. We present in this paper, MeTDiff, a …


Familial Cancers: Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers

February 26, 2015

Chongjuan Wei 1, Bo Peng, Younghun Han, Wei V Chen, Joshua Rother, Gail E Tomlinson, C Richard Boland, Damien Chaussabel, Marsha L Frazier, Christopher I Amos Erratum in Erratum to: Mutations of HNRNPA0 and WIF1 predispose members of a large family to …


Texas Public Radio: The Source: President’s Precision Medicine Initiative Has San Antonio Connection

February 15, 2015

President Obama announced in his State of the Union Address and followed up with details in late January, a $215 million plan to better design drugs and therapies to work on individual patients rather than average ones. Precision medicine isn’t new, it …


Genes & Cancer: Microarray profile of human kidney from diabetes, renal cell carcinoma and renal cell carcinoma with diabetes

February 14, 2015

Adam Kosti2, Hung-I Harry Chen4, Sumathy Mohan3, Sitai Liang2, Yidong Chen4,5, and Samy L. Habib1,2 ABSTRACT A recent study from our laboratory showed that patients with diabetes are at a higher risk of developing kidney cancer. In the current study, w …


SA Express-News: Childhood cancer survivor active in Obama’s ‘precision medicine’ effort

February 9, 2015

S.A. scientist also a cancer survivor As a childhood cancer survivor, San Antonio pediatric oncologist Greg Aune understood the excitement felt by cancer patients and their families when President Barack Obama announced his “precision medicine” initiat …


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