Greehey CCRI Archives

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Journal of Oral Pathology & Medicine: The novel capsazepine analog, CIDD‐99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1‐independent induction of ER stress, mitochondrial dysfunction, and apoptosis

February 3, 2019

Jorge J. De La Chapa, Prajjal K. Singha, Kristen K. Self, McKay L. Sallaway, Stanton F. McHardy, Matthew J. Hart, Howard Stan McGuff, Matthew C. Valdez Francisco Ruiz II, Srikanth R. Polusani, Cara B. Gonzales Abstract Background Oral squamous cell car …


Oncology Learning Network: Podcast – Daunorubicin Decreases Long-Term Cardiomyopathy Risk in Cancer Survivors

January 31, 2019

In an interview with Oncology Learning Network, Gregory J. Aune, MD, Assistant Professor of Pediatrics at UT Health San Antonio and Greehey Children’s Cancer Research Institute, discussed his team’s findings from a multicenter study evaluating the long …


Science Daily: Do all chemotherapies have equal long-term heart risk? (Aune & Tomlinson Labs)

January 31, 2019

In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published Jan. 31 in JAMA Oncology, researchers compared four chemotherapy drugs with the development of cardio …


Drug Discovery & Development: Do All Chemotherapies Have Equal Long-Term Heart Risk?

January 31, 2019

Gregory Aune, MD, PhD, of UT Health San Antonio, served on a team that found different chemotherapy drugs used to treat children with cancer appear to have different risks long term for cardiomyopathy (abnormal heart muscle with impaired function). The …


UT Health SA Newsroom: Do all chemotherapies have equal heart risk long term?

January 31, 2019

Study of 28,000 childhood cancer survivors finds important differences In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published Jan. 31 in JAMA Oncology, rese …


BMC Medical Genomics: Predicting drug response of tumors from integrated genomic profiles by deep neural networks

January 31, 2019

Yu-Chiao Chiu, Hung-I Harry Chen, Tinghe Zhang, Songyao Zhang, Aparna Gorthi, Li-Ju Wang, Yufei Huang & Yidong Chen Abstract Background The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insig …


Vimeo: Paws for Cure: Courageous Warriors: Cancer Patients’ Perspectives

January 31, 2019

https://vimeo.com/314646779 “Moderator: Dr. Len Lichtenfeld, MD, Deputy Chief Medical Officer, American Cancer Society Mary Tankersley, Survivor, Rally Foundation Ambassador Dr. Greg Aune, MD, PhD, Pediatric Oncologist, Greehey Children’s Cancer Resear …


JAMA Oncology: Derivation of Anthracycline and Anthraquinone Equivalence Ratios to Doxorubicin for Late-Onset Cardiotoxicity

January 31, 2019

Elizabeth A. M. Feijen, PhD1,2; Wendy M. Leisenring, ScD3,4; Kayla L. Stratton, MS3,4; Kirsten K. Ness, PT, PhD5; Helena J. H. van der Pal, MD, PhD2; Elvira C. van Dalen, MD, PhD1,2; Gregory T. Armstrong, MD, MSCE5; Gregory J. Aune, MD, PhD6; Daniel M. …


EurekAlert: Do all chemotherapies have equal long-term heart risk?

January 21, 2019

SAN ANTONIO — In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published Jan. 31 in JAMA Oncology, researchers compared four chemotherapy drugs with the develo …


MDPI: CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere

January 15, 2019

Yohei Niikura 1,2,* Risa Kitagawa 1 and Katsumi Kitagawa 1,* Abstract The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centr …