Greehey CCRI News & Events Archive

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Molecular & Cellular Biology: A Conditional Mouse Model for Measuring the Frequency of Homologous Recombination Events In Vivo in the Absence of Essential Genes

August 10, 2011

Adam D. Brown, Alison B. Claybon, Alexander J. R. Bishop ABSTRACT The ability to detect and repair DNA damage is crucial to the prevention of various diseases. The loss of function of genes involved in these processes is known to result in significant …


UT Health SA Newsroom: CPRIT honors San Antonio cancer investigators

July 15, 2011

A ceremony marking Cancer Prevention and Research Institute of Texas’ awards totaling almost $13 million in cancer research dollars to San Antonio health and academic institutions. UT Health Science Center primary award – multi-institutional, multi-inv …


Plos One: Preferential Localization of Human Origins of DNA Replication at the 5′-Ends of Expressed Genes and at Evolutionarily Conserved DNA Sequences

May 13, 2011

Manuel S. Valenzuela  ,Yidong Chen ,Sean Davis,Fan Yang,Robert L. Walker,Sven Bilke,John Lueders,Melvenia M. Martin,Mirit I. Aladjem,Pierre P. Massion, Paul S. Meltzer  Abstract Background Replication of mammalian genomes requires the activation of tho …


JoVE Journal: Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium

February 27, 2011

Alison Claybon1, Alexander J. R. Bishop1 Abstract The retinal pigment epithelium (RPE) lies at the back of the mammalian eye, just under the neural retina, which contains the photoreceptors (rods and cones). The RPE is a monolayer of pigmented cuboidal …


Cancer Cell: Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma

February 1, 2011

Brian P.Rubin1, KoichiNishijo2, Hung-I HarryChen2, XiaolanYi2, David P.Schuetze1, RanadipPal3, Suresh I.Prajapati2, JinuAbraham2, Benjamin R.Arenkiel4, Qing-RongChen5, SeanDavis6, Amanda T.McCleish2, Mario R.Capecchi7, Joel E.Michalek8, Lee AnnZarzabal …


PLOS One: 14-3-3 σ Expression Effects G2/M Response to Oxygen and Correlates with Ovarian Cancer Metastasis

January 10, 2011

Dashnamoorthy Ravi, Yidong Chen, Bijal Karia, Adam Brown, Ting Ting Gu, Jie Li, Mark S. Carey, Bryan T. Hennessy, Abstract Background In vitro cell, culture experiments with primary cells have reported that cell proliferation is retarded in the presenc …


BMC Genomics: Robust inference of the context specific structure and temporal dynamics of gene regulatory network

December 1, 2010

Jia Meng, Mingzhu Lu, Yidong Chen, Shou-Jiang Gao & Yufei Huang Abstract Background The response of cells to changing endogenous or exogenous conditions is governed by intricate molecular interactions or regulatory networks. To lead to appropriate …


BMC Genomics: A Bayesian approach for identifying miRNA targets by combining sequence prediction and gene expression profiling

December 1, 2010

Hui Liu, Dong Yue, Lin Zhang, Yidong Chen, Shou-Jiang Gao & Yufei Huang Abstract Background MicroRNAs (miRNAs) are single-stranded non-coding RNAs shown to plays important regulatory roles in a wide range of biological processes and diseases. The f …


BMC Bioinformatics: Improving performance of mammalian microRNA target prediction

September 22, 2010

Hui Liu, Dong Yue, Yidong Chen, Shou-Jiang Gao & Yufei Huang Abstract Background MicroRNAs (miRNAs) are single-stranded non-coding RNAs known to regulate a wide range of cellular processes by silencing the gene expression at the protein and/or mRNA …


Journal of Nucleic Acids: Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion

August 19, 2010

Adam D. Brown,1,2 Alison B. Claybon,1 and Alexander J. R. Bishop1,2 Abstract Werner syndrome is a rare disorder that manifests as premature aging and age-related diseases. WRN is the gene mutated in WS, and is one of five human RecQ helicase family mem …