Greehey CCRI News & Events Archive
Molecular & Cellular Biology: A Conditional Mouse Model for Measuring the Frequency of Homologous Recombination Events In Vivo in the Absence of Essential Genes
August 10, 2011Adam D. Brown, Alison B. Claybon, Alexander J. R. Bishop ABSTRACT The ability to detect and repair DNA damage is crucial to the prevention of various diseases. The loss of function of genes involved in these processes is known to result in significant …
UT Health SA Newsroom: CPRIT honors San Antonio cancer investigators
July 15, 2011A ceremony marking Cancer Prevention and Research Institute of Texas’ awards totaling almost $13 million in cancer research dollars to San Antonio health and academic institutions. UT Health Science Center primary award – multi-institutional, multi-inv …
Plos One: Preferential Localization of Human Origins of DNA Replication at the 5′-Ends of Expressed Genes and at Evolutionarily Conserved DNA Sequences
May 13, 2011Manuel S. Valenzuela ,Yidong Chen ,Sean Davis,Fan Yang,Robert L. Walker,Sven Bilke,John Lueders,Melvenia M. Martin,Mirit I. Aladjem,Pierre P. Massion, Paul S. Meltzer Abstract Background Replication of mammalian genomes requires the activation of tho …
JoVE Journal: Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium
February 27, 2011Alison Claybon1, Alexander J. R. Bishop1 Abstract The retinal pigment epithelium (RPE) lies at the back of the mammalian eye, just under the neural retina, which contains the photoreceptors (rods and cones). The RPE is a monolayer of pigmented cuboidal …
Cancer Cell: Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma
February 1, 2011Brian P.Rubin1, KoichiNishijo2, Hung-I HarryChen2, XiaolanYi2, David P.Schuetze1, RanadipPal3, Suresh I.Prajapati2, JinuAbraham2, Benjamin R.Arenkiel4, Qing-RongChen5, SeanDavis6, Amanda T.McCleish2, Mario R.Capecchi7, Joel E.Michalek8, Lee AnnZarzabal …
PLOS One: 14-3-3 σ Expression Effects G2/M Response to Oxygen and Correlates with Ovarian Cancer Metastasis
January 10, 2011Dashnamoorthy Ravi, Yidong Chen, Bijal Karia, Adam Brown, Ting Ting Gu, Jie Li, Mark S. Carey, Bryan T. Hennessy, Abstract Background In vitro cell, culture experiments with primary cells have reported that cell proliferation is retarded in the presenc …
BMC Genomics: Robust inference of the context specific structure and temporal dynamics of gene regulatory network
December 1, 2010Jia Meng, Mingzhu Lu, Yidong Chen, Shou-Jiang Gao & Yufei Huang Abstract Background The response of cells to changing endogenous or exogenous conditions is governed by intricate molecular interactions or regulatory networks. To lead to appropriate …
BMC Genomics: A Bayesian approach for identifying miRNA targets by combining sequence prediction and gene expression profiling
December 1, 2010Hui Liu, Dong Yue, Lin Zhang, Yidong Chen, Shou-Jiang Gao & Yufei Huang Abstract Background MicroRNAs (miRNAs) are single-stranded non-coding RNAs shown to plays important regulatory roles in a wide range of biological processes and diseases. The f …
BMC Bioinformatics: Improving performance of mammalian microRNA target prediction
September 22, 2010Hui Liu, Dong Yue, Yidong Chen, Shou-Jiang Gao & Yufei Huang Abstract Background MicroRNAs (miRNAs) are single-stranded non-coding RNAs known to regulate a wide range of cellular processes by silencing the gene expression at the protein and/or mRNA …
Journal of Nucleic Acids: Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion
August 19, 2010Adam D. Brown,1,2 Alison B. Claybon,1 and Alexander J. R. Bishop1,2 Abstract Werner syndrome is a rare disorder that manifests as premature aging and age-related diseases. WRN is the gene mutated in WS, and is one of five human RecQ helicase family mem …