Greehey CCRI News & Events Archive

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Bioinformatics: A novel significance score for gene selection and ranking

March 15, 2014

Yufei Xiao, Tzu-Hung Hsiao, Uthra Suresh, Hung-I Harry Chen, Xiaowu Wu, Steven E. Wolf, Yidong Chen Abstract Motivation: When identifying differentially expressed (DE) genes from high-throughput gene expression measurements, we would like to take both …


Science Daily: Improved screening means new targets for pediatric neuroblastoma therapies

March 2, 2014

Neuroblastoma is one of the most common and lethal types of childhood cancers. In a paper recently published, a researcher unveils an improved screening technique that shows the important role of microRNAs in regulating neuroblastoma development, point …


Oncotarget: A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation

February 28, 2014

Zhenze Zhao1, Xiuye Ma1, Tzu-Hung Hsiao1, Gregory Lin1, Adam Kosti1, Xiaojie Yu2, Uthra Suresh1, Yidong Chen1,3, Gail E. Tomlinson1,4, Alexander Pertsemlidis1,4,5, Liqin Du1,5 ABSTRACT Neuroblastoma, the most common extracranial solid tumor of childhoo …


PLOS One: Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

January 14, 2014

Wilson C. Fok, Yidong Chen, Alex Bokov, Yiqiang Zhang, Adam B. Salmon, Vivian Diaz, Martin Javors, William H. Wood 3rd, Yongqing Zhang, Kevin G. Becker, Viviana I. Pérez, Arlan Richardson  Abstract Rapamycin was found to increase (11% to 16%) the lifes …


Molecular Ecology Resources: Genomics of Compositae crops: reference transcriptome assemblies and evidence of hybridization with wild relatives

January 1, 2014

Kathryn A Hodgins 1, Zhao Lai, Luiz O Oliveira, David W Still, Moira Scascitelli, Michael S Barker, Nolan C Kane, Hannes Dempewolf, Alex Kozik, Richard V Kesseli, John M Burke, Richard W Michelmore, Loren H Rieseberg Abstract Although the Compositae ha …


Molecular Oncology: PELP1 oncogenic functions involve alternative splicing via PRMT6

December 30, 2013

Monica Mann, Yi Zou, Yidong Chen, Darrell Brann, Ratna Vadlamudi Abstract Proline‐, glutamic acid‐, and leucine‐rich protein 1 (PELP1) is a proto‐oncogene that functions as a coactivator of the estrogen receptor and is an independent prognostic predict …


Aging Cell: Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

December 13, 2013

Wilson C. Fok  Alex Bokov Jonathan Gelfond Zhen Yu Yiqiang Zhang Mark Doderer Yidong Chen Martin Javors William H. Wood III Yongqing Zhang Kevin G. Becker Arlan Richardson Viviana I. Pérez Summary Rapamycin (Rapa) and dietary restriction (DR) have cons …


BMC Systems Biology: BRCA-Monet: a breast cancer specific drug treatment mode-of-action network for treatment effective prediction using large scale microarray database

December 9, 2013

Chifeng Ma, Hung-I Harry Chen, Mario Flores, Yufei Huang & Yidong Chen Abstract Background Connectivity map (cMap) is a recently developed dataset and algorithm for uncovering and understanding the treatment effect of small molecules on different c …


Journal of Biological Chemistry: The RHOX Homeodomain Proteins Regulate the Expression of Insulin and Other Metabolic Regulators in the Testis*

November 29, 2013

James A. MacLean II‡,§, Zhiying Hu§, Joshua P. Welborn‡, Hye-Won Song§,¶,‖, Manjeet K. Rao§,**, Chad M. Wayne§,‡‡ and Miles F. Wilkinson§,¶,‖1 Abstract Defects in cellular metabolism have been widely implicated in causing male infertility, but there ha …


Skeletal Muscle: Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma

November 25, 2013

Ken Kikuchi, Eri Taniguchi, Hung-I Harry Chen, Matthew N Svalina, Jinu Abraham, Elaine T Huang, Koichi Nishijo, Sean Davis, Christopher Louden, Lee Ann Zarzabal, Olivia Recht, Ayeza Bajwa, Noah Berlow, Mònica Suelves, Sherrie L Perkins, Paul S Meltzer, …


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