Greehey CCRI News & Events Archive
Nucleic Acids Research: PARP1 suppresses homologous recombination events in mice “in vivo”
July 21, 2010Alison Claybon, Bijal Karia, Crystal Bruce, Alexander J. R. Bishop Abstract Recent studies suggest that PARP1 inhibitors, several of which are currently in a clinical trial, may selectively kill BRCA1/2 mutant cancer cells. It is thought that the succe …
Oncogene: MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers
July 5, 2010J S Imam, K Buddavarapu, J S Lee-Chang, S Ganapathy, C Camosy, Y Chen & M K Rao Abstract Homeobox genes encode transcription factors that are essential for normal development and are often dysregulated in cancers. The molecular mechanisms that caus …
BMC Systems Biology: Building and analyzing protein interactome networks by cross-species comparisons
March 30, 2010Amy M Wiles, Mark Doderer, Jianhua Ruan, Ting-Ting Gu, Dashnamoorthy Ravi, Barron Blackman & Alexander JR Bishop Abstract Background A genomic catalog of protein-protein interactions is a rich source of information, particularly for exploring the r …
PLOS Genetics: A Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen
October 19, 2009Dashnamoorthy Ravi, Amy M. Wiles, Selvaraj Bhavani, Jianhua Ruan, Philip Leder, Alexander J. R. Bishop Abstract Damage initiates a pleiotropic cellular response aimed at cellular survival when appropriate. To identify genes required for damage surviva …
New England Journal of Medicine: MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer
October 8, 2009Junfang Ji, Ph.D., Jiong Shi, M.D., Anuradha Budhu, Ph.D., Zhipeng Yu, B.S., Marshonna Forgues, B.S., Stephanie Roessler, Ph.D., Stefan Ambs, Ph.D., M.P.H., Yidong Chen, Ph.D., Paul S. Meltzer, M.D., Carlo M. Croce, M.D., Lun-Xiu Qin, M.D., Ph.D., Kwan …
Plos Genetics: A Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen
June 19, 2009Abstract Damage initiates a pleiotropic cellular response aimed at cellular survival when appropriate. To identify genes required for damage survival, we used a cell-based RNAi screen against the Drosophila genome and the alkylating agent methyl methan …
UT Health SA Newsroom: Noted childhood cancer researchers to meet in San Antonio
February 9, 2009About 100 scientists from noted cancer centers will gather in downtown San Antonio Feb. 26-27 to share findings and exchange ideas at the Genetics and Biology of Childhood Cancer 2009 symposium. It is the first scientific meeting sponsored by The Greeh …
Cancer Research: Large-Scale Profiling of Archival Lymph Nodes Reveals Pervasive Remodeling of the Follicular Lymphoma Methylome
February 1, 2009J. Keith Killian, Sven Bilke, Sean Davis, Robert L. Walker, M. Scott Killian, Erich B. Jaeger, Yidong Chen, Jason Hipp, Stefania Pittaluga, Mark Raffeld, Robert Cornelison, William I. Smith, Jr., Marina Bibikova, Jian-Bing Fan, Michael R. Emmert-Buck, …
Bioinformatics: GEOmetadb: powerful alternative search engine for the Gene Expression Omnibus
December 1, 2008Yuelin Zhu, Sean Davis, Robert Stephens, Paul S. Meltzer, Yidong Chen Abstract The NCBI Gene Expression Omnibus (GEO) represents the largest public repository of microarray data. However, finding data in GEO can be challenging. We have developed GEOmet …
Bioinformatics: A probe-density-based analysis method for array CGH data: simulation, normalization and centralization
October 1, 2008Hung-I Harry Chen, Fang-Han Hsu, Yuan Jiang, Mong-Hsun Tsai, Pan-Chyr Yang, Paul S. Meltzer, Eric Y. Chuang, Yidong Chen Abstract Motivation: Genomic instability is one of the fundamental factors in tumorigenesis and tumor progression. Many studies hav …