Greehey CCRI News & Events Archive

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IEEE: Evaluating Dynamic Effects of Copy Number Alterations on Gene Expression Using a Single Transcription Model

July 13, 2012

Fang-Han Hsu; Erchin Serpedin; Yidong Chen; Edward R. Dougherty Abstract: DNA copy number alterations (CNAs) are known to be related to genetic diseases, including cancer. The unlimited transcription (UT) model, in which transcription occurs permissive …


South Texas Medical Center: Regulation by proteins outside cancer cells points to potential new drug target

July 9, 2012

Protein interactions outside breast cancer cells can send signals to the cancer cells to permanently stop proliferating, a new study showed in the School of Medicine at The University of Texas Health Science Center San Antonio. “Because this protein ca …


Expert Opinion on Biological Therapy: microRNA regulation of cell viability and drug sensitivity in lung cancer

June 26, 2012

Liqin Du , & Alexander Pertsemlidis Abstract Introduction:microRNAs (miRNAs) are 19 – 23 nucleotide long RNAs found in multiple organisms that regulate gene expression and have been shown to play important roles in tumorigenesis. In the context of …


Transnational Cancer Research: Chain-reaction, a model of gene expression dynamics

June 21, 2012

Submitted May 21, 2012. Accepted for publication Jun 21, 2012. doi: 10.3978/j.issn.2218-676X.2012.06.01 One of the fundamental studies of transcription response to stimuli is to model the activation, repression of hundreds of genes, and their regulatio …


PLoS One: miR-337-3p and Its Targets STAT3 and RAP1A Modulate Taxane Sensitivity in Non-Small Cell Lung Cancers

June 18, 2012

Liqin Du, Maria C. Subauste, Christopher DeSevo, Zhenze Zhao, Michael Baker, Robert Borkowski, Jeoffrey J. Schageman, Rachel Greer, Chin-Rang Yang, Milind Suraokar, Ignacio I. Wistuba, Adi F. Gazdar, John D. Minna, Alexander Pertsemlidis  Abstract NSCL …


Cancer Epidemiology Biomarkers & Prevention: Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers

May 11, 2012

Amanda B Spurdle 1, Louise Marquart, Lesley McGuffog, Sue Healey, Olga Sinilnikova, Fei Wan, Xiaoqing Chen, Jonathan Beesley, Christian F Singer, Anne-Catharine Dressler, Daphne Gschwantler-Kaulich, Joanne L Blum, Nadine Tung, Jeff Weitzel, Henry Lynch …


Science: Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

April 13, 2012

In Hye Lee1, Yoshichika Kawai1, Maria M. Fergusson1, Ilsa I. Rovira1, Alexander J. R. Bishop2, Noboru Motoyama3, Liu Cao4,*, Toren Finkel1,* Starvation and Autophagy Starvation stimulates withdrawal from the cell cycle, as well as stimulating autophagy …


PNAS: Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation

April 10, 2012

Yao-Fu Chang, Jennifer S. Lee-Chang, J. Saadi Imam, Kalyan Chakravarthy Buddavarapu, Sarah S. Subaran, Amiya P. Sinha-Hikim, Myriam Gorospe, and Manjeet K. Rao Abstract Decoupling of transcription and translation during postmeiotic germ cell differenti …


Human Reproduction: Parental infertility, infertility treatment and hepatoblastoma: a report from the Children’s Oncology Group

April 3, 2012

Susan E Puumala 1, Julie A Ross, James H Feusner, Gail E Tomlinson, Marcio H Malogolowkin, Mark D Krailo, Logan G Spector Abstract Background: A recent study suggested a markedly increased risk of hepatoblastoma (HB) among children conceived with treat …


Experimental Hematology: Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm

April 1, 2012

Author links open overlay panelStephanie N.Zimmerab∗  Madeleine E.Lemieuxc∗  Bijal P.Kariaab  ClaudiaDayb  TingZhouab  QingZhoub  Andrew L.Kungc  UthraSuresh  bYidongChenbd  Marsha C.Kinneye  Alexander J.R.Bishopab  Vivienne I.Rebel Myelodysplastic syn …


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