Greehey CCRI News & Events Archive

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Journal of Clinical Oncology: Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers

March 19, 2012

Brian S Finkelman 1, Wendy S Rubinstein, Sue Friedman, Tara M Friebel, Shera Dubitsky, Niecee Singer Schonberger, Rochelle Shoretz, Christian F Singer, Joanne L Blum, Nadine Tung, Olufunmilayo I Olopade, Jeffrey N Weitzel, Henry T Lynch, Carrie Snyder, …


Molecular Biology of the Cell: Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells

February 22, 2012

Shu Lin 1, Junhua Yang, Abdel G Elkahloun, Abhik Bandyopadhyay, Long Wang, John E Cornell, I-Tien Yeh, Joseph Agyin, Gail Tomlinson, Lu-Zhe Sun Abstract The molecular mechanisms that drive triple-negative, basal-like breast cancer progression are elusi …


UT Health SA Newsroom: CPRIT awards $4.7 million to Health Science Center

January 18, 2012

Two University of Texas Health Science Center at San Antonio researchers today were awarded a total of $4.7 million by the Cancer Prevention and Research Institute of Texas (CPRIT). These awards for cancer prevention, along with $2.9 million to Univers …


Gastroenterology: Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival

December 3, 2011

Background & Aims Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers ass …


Stand Genomic Sciences: Minimum Information about a Genotyping Experiment (MIGEN)

November 30, 2011

Jie Huang, Daniel Mirel, Elizabeth Pugh, Chao Xing, Peter N Robinson, Alexander Pertsemlidis, Lianghao Ding, Julia Kozlitina, Joseph Maher, Jonathan Rios, Michael Story, Nishanth Marthandan, Richard H Scheuermann Abstract Genotyping experiments are wid …


Breast Cancer Research: Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

November 12, 2011

Anna Marie Mulligan 1, Fergus J Couch, Daniel Barrowdale, Susan M Domchek, Diana Eccles, Heli Nevanlinna, Susan J Ramus, Mark Robson, Mark Sherman, Amanda B Spurdle, Barbara Wappenschmidt, Andrew Lee, Lesley McGuffog, Sue Healey, Olga M Sinilnikova, Ra …


Biotechniques: Isolation of Sertoli, Leydig, and spermatogenic cells from the mouse testis

November 5, 2011

Yao-Fu Chang 1, Jennifer S Lee-Chang, Subbarayalu Panneerdoss, James A MacLean 2nd, Manjeet K Rao Abstract A thorough understanding of the events during mammalian spermatogenesis requires studying specific molecular signatures of individual testicular …


Journal of Biological Chemistry: Mutant p53 Disrupts Role of ShcA Protein in Balancing Smad Protein-dependent and -independent Signaling Activity of Transforming Growth Factor-β (TGF-β)*

October 26, 2011

Shu Lin‡, Lan Yu‡, Junhua Yang‡, Zhao Liu‡, Bijal Karia‡§, Alexander J. R. Bishop‡§¶, James Jackson‖, Guillermina Lozano‖, John A. Copland**, Xiaoxin Mu‡‡‡, Beicheng Sun‡‡ and Lu-Zhe Sun‡¶,1 Abstract Biomarkers are lacking for identifying the switch of …


IEEE: Stochastic Modeling of the Relationship between Copy Number and Gene Expression Based on Transcriptional Logic

October 24, 2011

Fang-Han Hsu; Erchin Serpedin; Yidong Chen; Edward R. Dougherty Abstract: DNA copy number alterations (CNAs) can cause genetic diseases, and studies have revealed a relationship between CNAs and gene expression; however, the manner in which CNAs relate …


Molecular Profiling: Genome-Wide Methylation Profiling in Archival Formalin-Fixed Paraffin-Embedded Tissue Samples

October 21, 2011

J. Keith Killian, Robert L. Walker, Sven Bilke, Yidong Chen, Sean Davis, Robert Cornelison, William I. Smith, Paul S. Meltzer Abstract New technologies allow for the genome-scale measurement of DNA methylation. In an effort to increase the clinical uti …


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