Greehey CCRI Archives
NIH: Searching for Less Toxic Cancer Treatments for Kids (Aune Lab)
September 21, 2017Advances in cancer treatment mean that today, more than 4 out of 5 children diagnosed with cancer will survive and remain cancer-free for at least 5 years after diagnosis. Many of these children will ultimately be considered cured of their cancer. Howe …
JoVE: Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
September 20, 2017Helia N Sanchez 1, Tian Shen 2, Dawn Garcia 3, Zhao Lai 3, Paolo Casali 1, Hong Zan 4 Abstract Antibody responses are accomplished through several critical B cell-intrinsic processes, including somatic hypermutation (SHM), class-switch DNA recombinatio …
Nature Communications: Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
September 19, 2017Subbarayalu Panneerdoss, Suryavathi Viswanadhapalli, Nourhan Abdelfattah, Benjamin C. Onyeagucha, Santosh Timilsina, Tabrez A. Mohammad, Yidong Chen, Michael Drake, Kristiina Vuori, T. Rajendra Kumar & Manjeet K. Rao Abstract Phagocytic clearance o …
Oncotarget: Novel post-transcriptional and post-translational regulation of pro-apoptotic protein BOK and anti-apoptotic protein Mcl-1 determine the fate of breast cancer cells to survive or die
September 12, 2017Benjamin Onyeagucha1,2, Panneerdoss Subbarayalu1,2, Nourhan Abdelfattah1,2, Subapriya Rajamanickam1,2, Santosh Timilsina1,2, Rosa Guzman1, Carla Zeballos2, Vijay Eedunuri1,2, Sanjay Bansal1, Tabrez Mohammad2, Yidong Chen1,3, Ratna K. Vadlamudi4, and Ma …
Cancer Knowledge Network: The Financial Impact of Surviving Childhood Cancer
September 7, 2017Journal of Clinical Oncology — Financial Burden in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study. Researchers evaluated self-reported household income data available through the Childhood Cancer Survivor Study (CCSS) …
Familial Cancer: Discovery of mutations in homologous recombination genes in African-American women with breast cancer
September 2, 2017Yuan Chun Ding 1, Aaron W Adamson 1, Linda Steele 1, Adam M Bailis 2, Esther M John 3 4, Gail Tomlinson 5 6, Susan L Neuhausen 7 Abstract African-American women are more likely to develop aggressive breast cancer at younger ages and experience poorer c …
Human Genetics: RNA processing as an alternative route to attack glioblastoma
September 1, 2017Fabiana Marcelino Meliso, Christopher G Hubert, Pedro A Favoretto Galante, Luiz O Penalva Genomic analyses have become an important tool to identify new avenues for therapy. This is especially true for cancer types with extremely poor outcomes since ou …
Human Genetics: From mechanisms to therapy: RNA processing’s impact on human genetics
September 1, 2017Authors Luiz O Penalva, Jeremy R Sanford Protein-coding genes defy the one gene-one enzyme paradigm, in part, through the process of alternative pre-mRNA splicing. This mode of gene regulation is critical for generating protein isoforms with specific f …
Journal of Clinical and Translational Science: 2337: Doxorubicin exposure in vitro stimulates ROS production and directly suppresses cardiac fibroblast proliferation
September 1, 2017Trevi A. Mancilla (a1) and Gregory J. Aune (a1) Trevi A. Mancilla and Gregory J. Aune Abstract OBJECTIVES/SPECIFIC AIMS: Our research strives to understand the pathophysiology of doxorubicin cardiotoxicity, focusing on the understudied nonmyocyte cardi …
Scientific Reports: A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
August 22, 2017Jing Lin, Roza Zandi, Ruping Shao, Jian Gu, Yuanqin Ye, Jing Wang, Yang Zhao, Alexander Pertsemlidis, Ignacio I. Wistuba, Xifeng Wu, Jack A. Roth & Lin Ji Abstract Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association …