Greehey CCRI Archives
Cancer Knowledge Network: What Factors are Associated with Hearing Loss in Childhood Cancer Survivors Treated with Platinum Agents?
May 4, 2017THE RESEARCH: Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer: A DCOG late-effects study. Researchers compiled treatment data and audiograms from 451 childhood cancer survivors (CCS) treated at seven pediatric …
PLOS One: Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma
May 4, 2017Patricia C. Sanchez-Diaz ,Judy C. Chang ,Emily S. Moses,Tu Dao,Yidong Chen,Jaclyn Y. Hung Abstract Pediatric high-grade gliomas represent 8–12% of all primary tumors of the nervous system in children. Five-year survival for these pediatric aggressive …
Cancer Knowledge Network: Introducing Dr. Gregory Aune, Editor, Knowledge Translation: Childhood Cancer Survivorship
May 3, 2017My patient experiences motivated me to pursue medicine and science. I did so with the goal of improving outcomes for other cancer patients, once I had completed that long road. But along the way, I began to consistently encounter health problems caus …
InderScience: Computational tools for genome-wide R-loops identification and characterization
April 15, 2017Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in various organisms and shown to play important roles in regulating gene expression, …
International Journal of Computational Biology and Drug Design: Computational tools for genome-wide R-loops identification and characterisation
April 15, 2017Authors: Rongjie Liu; Aparna Gorthi; Yufang Jin; Alexander J.R. Bishop; Yidong Chen Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in …
PloS One: De-regulated microRNAs in pediatric cancer stem cells target pathways involved in cell proliferation, cell cycle and development
April 4, 2017Patricia C Sanchez-Diaz 1, Tzu-Hung Hsiao, Judy C Chang, Dong Yue, Mimi C Tan, Hung-I Harry Chen, Gail E Tomlinson, Yufei Huang, Yidong Chen, Jaclyn Y Hung Abstract Background: microRNAs (miRNAs) have been implicated in the control of many biological p …
Axios: More people are surviving a cancer diagnosis
April 2, 2017Survival rates for cancer patients in the U.S. continue to improve for many common types of the disease, according to a new report from top government agencies. Pancreatic, liver, brain, lung, and other cancers still have low rates of survival but pros …
BMC Genomics: Deep sequencing of HPV E6/E7 genes reveals loss of genotypic diversity and gain of clonal dominance in high-grade intraepithelial lesions of the cervix
March 14, 2017Jane Shen-Gunther 1, Yufeng Wang 2, Zhao Lai 3, Graham M Poage 4, Luis Perez 4, Tim H M Huang 5 Abstract Background: Human papillomavirus (HPV) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital mali …
Journal of Exposure Science & Environmental Epidemiology: Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children’s Oncology Group
March 8, 2017Amanda E Janitz, Gurumurthy Ramachandran, Gail E Tomlinson, Mark Krailo, Michaela Richardson & Logan Spector Abstract Little is known about the etiology of hepatoblastoma. We aimed to confirm the results of a previous study evaluating the associati …
BMC Bioinformatics: Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival
February 28, 2017Yu-Chiao Chiu, Li-Ju Wang, Tzu-Pin Lu, Tzu-Hung Hsiao, Eric Y. Chuang & Yidong Chen Abstract Background Recent studies illuminated a novel role of microRNA (miRNA) in the competing endogenous RNA (ceRNA) interaction: two genes (ceRNAs) can achieve …