Greehey CCRI Archives
BMC Bioinformatics: Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival
February 28, 2017Yu-Chiao Chiu, Li-Ju Wang, Tzu-Pin Lu, Tzu-Hung Hsiao, Eric Y. Chuang & Yidong Chen Abstract Background Recent studies illuminated a novel role of microRNA (miRNA) in the competing endogenous RNA (ceRNA) interaction: two genes (ceRNAs) can achieve …
AHA Journals – Circulation Research: Abstract 456: Early Doxorubicin Exposure Upregulates P-STAT3 Expression in Adult Murine Model
February 23, 2017Tanoya L Harris and Gregory J Aune Abstract Background: Anthracyclines such as doxorubicin (DOX) is a key component of chemotherapy treatments and also have cardiotoxic effects that can manifest decades after initial exposure. Long term survivors have …
Journal of Biological Chemistry: An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling
February 22, 2017Sun Kyung Kim‡1, Lindsey Barron§, Cynthia S. Hinck¶, Elyse M. Petrunak¶, Kristin E. Cano‡, Avinash Thangirala‡, Brian Iskra‡, Molly Brothers‡, Machell Vonberg‡, Belinda Leal‡, Blair Richter‡, Ravindra Kodali¶, Alexander B. Taylor‡, Shoucheng Du¶, Chris …
Biochemistry: Confinement and Stabilization of Fyn SH3 Folding Intermediate Mimetics within the Cavity of the Chaperonin GroEL Demonstrated by Relaxation-Based NMR
February 21, 2017David S Libich 1, Vitali Tugarinov 1, Rodolfo Ghirlando 1, G Marius Clore 1 Abstract The interaction of two folding intermediate mimetics of the model protein substrate Fyn SH3 with the chaperonin GroEL, a supramolecular foldase/unfoldase machine, has …
Scientia: Dr Peter Houghton – Novel Therapeutics For Childhood Solid Tumours
February 15, 2017Dr Peter Houghton’s group implements preclinical trials to identify new drugs that may be effective and less toxic treatments against childhood cancers. From patient-derived xenografts in immunodeficient mice to utilising canine cancer patients as mode …
Journal of Clinical Oncology: Successful integration of genetic counseling in a comprehensive childhood cancer survivorship clinic.
February 10, 2017Shafqat Shah, Gregory John Aune, Lindsey Mette, Natalie Poullard Background: Awareness of inherited genetic risk and cancer predisposition has markedly increased. Research has shown that germline mutations in known cancer predisposition genes are ident …
Bioinformatics: Riborex: fast and flexible identification of differential translation from Ribo-seq data
January 31, 2017Authors Wenzheng Li, Weili Wang, Philip J Uren, Luiz OF Penalva, Andrew D Smith Abstract Motivation Global analysis of translation regulation has recently been enabled by the development of Ribosome Profiling, or Ribo-seq, technology. This approach pro …
Pediatric Hematology Oncology: Paraneoplastic Galactorrhea in Childhood T-ALL: An Evaluation of Tumor-derived Prolactin
January 1, 2017Allison Grimes 1, Nooshin Mirkheshti, Bandana Chatterjee, Gail Tomlinson, Chatchawin Assanasen Abstract T-cell acute lymphoblastic leukemia (T-ALL) comprises 15% of childhood leukemia. Although multiagent pulse chemotherapy has improved event-free surv …
Washington Post: A new urgency to protect survivors of childhood cancer
December 25, 2016SAN ANTONIO — When Brittany Galan was diagnosed with leukemia at 6 weeks old, doctors warned her parents she had little chance of surviving — she was so young and so sick. But after being treated with chemotherapy, “I lived and lived!” said the exubera …
Developmental Cell: CENP-A Ubiquitylation Is Required for CENP-A Deposition at the Centromere
December 20, 2016YoheiNiikura1, RisaKitagawa1, KatsumiKitagawa1 Main Text CENP-A is a centromere-specific histone variant that determines centromere identity, but how it localizes to centromeres is not completely understood. Previously, we demonstrated that CENP-A depo …