Nature Structural & Molecular Biology: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer (Olsen Lab, Sung Lab)

September 26, 2025

 Anindita Nayak, Digant Nayak, Lijia Jia, Eliza A. Ruben, Suryavathi Viswanadhapalli, Priscila dos Santos Bury, Khaled Mohamed Nassar, Corey H. Yu, Anna A. Tumanova, Caleb M. Stratton, Pirouz Ebadi, Dmitri N. Ivanov, Patrick Sung, Ratna K. Vadlamudi, Elizabeth V. Wasmuth & Shaun K. Olsen Abstract Post-translational modification of proteins by SUMO (small ubiquitin-like modifier) regulates fundamental [...]

Journal of Clinical Investigation: Efficacy and safety of a therapeutic humanized FSH–blocking antibody in obesity and Alzheimer’s disease models (Gupta)

July 30, 2025

 Anusha R. Pallapati,1 Funda Korkmaz,1 Satish Rojekar,1 Steven Sims,1 Anurag Misra,2 Judit Gimenez–Roig,1 Aishwarya Gangadhar,1 Victoria Laurencin,1 Anissa Gumerova,1 Uliana Cheliadinova,1 Farhath Sultana,1 Darya Vasilyeva,1 Liam Cullen,1 Jonathan Schuermann,3 Jazz Munitz,4 Hasni Kannangara,1 Surabhi Parte,1 Georgii Pevnev,1 Guzel Burganova,1 Zehra Tumoglu,1 Ronit Witztum,1 Soleil Wizman,1 Natan Kramskiy,1 Liah Igel,1 Fazilet Sen,1 Anna Ranzenigo,4 Anne Macdonald,1 Susan Hutchison,1 Abraham J.P. Teunissen,4 Heather Burkart,5 Mansi Saxena,1 Yelena Ginzburg,1 Ki Goosens,1 Weibin Zhou,1 Vitaly Ryu,1 Ofer Moldavski,1 Orly Barak,1 Michael Pazianas,1 John Caminis,1 Shalender Bhasin,6 Richard Fitzgerald,7 Se-Min Kim,1 Matthew Quinn,5 Shozeb Haider,8 Susan Appt,5 Tal Frolinger,1 Clifford J. Rosen,9 Daria Lizneva,1 Yogesh K. Gupta,2 Tony Yuen,1 and Mone [...]

UT Health San Antonio scientists uncover how some cancers outsmart immune system (Rao, Sung, Zheng, & Chen Labs)

July 17, 2025

 Shared By: Claire Kowalick July 17, 2025 FOXM1 protein identified as key driver in immunotherapy resistance, unlocking new therapeutic avenues   For years, scientists have found the overexpression of a specific protein called FOXM1 in a wide range of cancers, including ovarian, breast, and pediatric cancers. A recent study by scientists at The University of Texas [...]

Nature Communications: Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia (Bishop Lab)

June 3, 2025

 July Carolina Romero, Sonal S. Tonapi,Manish Parihar,Eva Loranc,Henry E. Miller,Liesl A. Lawrence,Nicklas Bassani,Daniel G. Robledo,Lin Cao,Jia Nie,Kairi Kanda,Aiola Stoja,Natalia Garcia,Aparna Gorthi,Brian J. Stoveken,Teresa W-M Fan,Teresa A. Cassel,Shan Zha,James D. Lechleiter,Nicolas Musi,Lily Q. Dong,Andrew N. Lane &Alexander J. R. Bishop Abstract Ataxia-telangiectasia is a rare genetic disorder characterized by neurological defects, immunodeficiency, cancer predisposition, radiosensitivity, decreased blood vessel [...]

Nature Communications: Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory (Rao, Chen, Zheng, Sung Labs et al)

April 29, 2025

 Santosh Timilsina, Jian Yu Huang, Nourhan Abdelfattah, Daisy Medina, Deepika Singh, Shahad Abdulsahib, Panneerdoss Subbarayalu, Trong Phat Do, Prabhakar Pitta Venkata, Saif Nirzhor, Jack Prochnau, Mukund Bhandari, Siyuan Zheng, Yidong Chen, Gang Huang, Neelam Mukherjee, Robert Hromas, Patrick Sung, Virginia Kaklamani, Ratna Vadlamudi, Nu Zhang & Manjeet K. Rao Abstract The interplay between tumor cells and [...]

Neuro-Oncology: Dual Inhibition of MAPK and TORC1 Signaling Retards Development of Radiation Resistance in Pediatric BRAF V600E Glioma Models (Chen, Houghton, et al labs)

April 11, 2025

 Abstract Background MAPK pathway inhibitors (MAPKi) have shown significant efficacy in treating childhood BRAF-activated brain tumors. For tumors harboring BRAFV600E mutations, the drugs are rarely curative, and patients can become refractory to treatment. MAPKi, combining X-radiation therapy (XRT), may improve the cure rate, but the development of XRT-resistance is a challenge. Read Full Text

Cell: Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation (Gupta Lab)

January 17, 2025

 Giuseppe Quarto1,12 ∙ Andrea Li Greci1,12 ∙ Martin Bizet1,12 ∙ Audrey Penning1 ∙ Irina Primac1 ∙ Frédéric Murisier1 ∙ Liliana Garcia-Martinez2 ∙ Rodrigo L. Borges2 ∙ Qingzeng Gao3,4 ∙ Pradeep K.R. Cingaram2 ∙ Emilie Calonne1 ∙ Bouchra Hassabi1 ∙ Céline Hubert1 ∙ Adèle Herpoel1 ∙ Pascale Putmans1 ∙ Frédérique Mies1 ∙ Jérôme Martin1 ∙ Louis [...]

Nature: Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination (Sung, Libich)

September 12, 2024

 Sameer Salunkhe, James M. Daley, Hardeep Kaur, Nozomi Tomimatsu, Chaoyou Xue, Vivek B. Raina, Angela M. Jasper, Cody M. Rogers, Wenjing Li, Shuo Zhou, Rahul Mojidra, Youngho Kwon, Qingming Fang, Jae-Hoon Ji, Aida Badamchi Shabestari, O’Taveon Fitzgerald, Hoang Dinh, Bipasha Mukherjee, Amyn A. Habib, Robert Hromas, Alexander V. Mazin, Elizabeth V. Wasmuth, Shaun K. Olsen, [...]

Nature Communications: DSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis (Zhao)

August 20, 2024

 Yuxin Huang, Wenjing Li, Tzeh Foo, Jae-Hoon Ji, Bo Wu, Nozomi Tomimatsu, Qingming Fang, Boya Gao, Melissa Long, Jingfei Xu, Rouf Maqbool, Bipasha Mukherjee, Tengyang Ni, Salvador Alejo, Yuan He, Sandeep Burma, Li Lan, Bing Xia & Weixing Zhao Abstract DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB-fold [...]