Science Advances: Selective elimination of circulating effector CD8 T cells via LTβR blockade separates anti-CD137 efficacy from toxicity (Lai, Chen)

April 24, 2026

 Sergey A. Shein  Anna A. Korchagina  Li-Ju Wang Zhao Lai, Yidong Chen  Jacob S. Fisher  Burkhard Ludewig Jessica N. Lancaster  Yang-Xin Fu , Ekaterina Koroleva and Alexei V. Tumanov Abstract The major barrier to clinical translation of αCD137 immunotherapy is separating antitumor efficacy from hepatotoxicity driven by IFN-γ–producing CD8 T cells. We propose a strategy to limit toxicity by promoting contraction of excessively expanded CD8 T cells. We identify [...]

Nature Structural & Molecular Biology: Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex (Sung Lab, Rao Lab)

April 1, 2026

 Abstract Senataxin (SETX), an RNA–DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX–BRCA1 resolves transcription-associated R-loops to prevent deleterious outcomes. Specifically, we show that full-length SETX unwinds R-loops with broad specificity and that the complex of BRCA1 and its obligatory partner BARD1 binds R-loops [...]

Cancer Research: Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity (Rao, Zhou, Hromas, Sung, Chen, et al)

December 3, 2025

 Deepika Singh Benjamin C. Onyeagucha Daisy Medina Panneerdoss Subbarayalu Rahul Mojidra Dongwen Lv Mukund Bhandari Santosh Timilsina Prabhakar Pitta Venkata Jian Yu. Huang Saif Nirzhor Shahad Abdulsahib Jack Yancy. Prochnau Chris TP. Do Subapriya Rajamanickam Yidong Chen Alexander B. Taylor Suryavathi Viswanadhapalli Maria E. Falzone Jean Jiang Patrick Sung Daohong Zhou Abstract Approaches targeting factors [...]

Cancer Research: Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity (Rao, Zhou, Hromas, Sung, Chen

December 3, 2025

 Deepika Singh Benjamin C. Onyeagucha Daisy Medina Panneerdoss Subbarayalu Rahul Mojidra Dongwen Lv Mukund Bhandari Santosh Timilsina Prabhakar Pitta Venkata Jian Yu. Huang Saif Nirzhor Shahad Abdulsahib Jack Yancy. Prochnau Chris TP. Do Subapriya Rajamanickam Yidong Chen Alexander B. Taylor Suryavathi Viswanadhapalli Maria E. Falzone Jean Jiang Patrick Sung Daohong Zhou Abstract Approaches targeting factors [...]

Molecular Cell: Deubiquitinases cleave ubiquitin-fused ribosomal proteins and physically counteract their targeting to the UFD pathway (Olsen)

December 1, 2025

 Stephanie Patchett 1 5, Seyed Arad Moghadasi 1 5, Ankita Shukla 2, Farid El Oualid 3, Beatrix M. Ueberheide 1 4, Shaun K. Olsen 2, Tony T. Huang 1 6 Highlights Cleavage-resistant ubiquitin-fused human ribosomal proteins (RPs) impair ribosome function Unprocessed, Ub-fused RPs are targeted for proteasomal degradation by the UFD pathway DUB activity-based probes for Ub-fused RPs identify Cezanne/OTUD7B and other DUBs Catalytic activity-independent DUB association with Ub-RPs prevents their degradation Summary In eukaryotes, each ribosomal subunit includes [...]

Nature Structural & Molecular Biology: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer (Olsen Lab, Sung Lab)

September 26, 2025

 Anindita Nayak, Digant Nayak, Lijia Jia, Eliza A. Ruben, Suryavathi Viswanadhapalli, Priscila dos Santos Bury, Khaled Mohamed Nassar, Corey H. Yu, Anna A. Tumanova, Caleb M. Stratton, Pirouz Ebadi, Dmitri N. Ivanov, Patrick Sung, Ratna K. Vadlamudi, Elizabeth V. Wasmuth & Shaun K. Olsen Abstract Post-translational modification of proteins by SUMO (small ubiquitin-like modifier) regulates fundamental [...]

Journal of Clinical Investigation: Efficacy and safety of a therapeutic humanized FSH–blocking antibody in obesity and Alzheimer’s disease models (Gupta)

July 30, 2025

 Anusha R. Pallapati,1 Funda Korkmaz,1 Satish Rojekar,1 Steven Sims,1 Anurag Misra,2 Judit Gimenez–Roig,1 Aishwarya Gangadhar,1 Victoria Laurencin,1 Anissa Gumerova,1 Uliana Cheliadinova,1 Farhath Sultana,1 Darya Vasilyeva,1 Liam Cullen,1 Jonathan Schuermann,3 Jazz Munitz,4 Hasni Kannangara,1 Surabhi Parte,1 Georgii Pevnev,1 Guzel Burganova,1 Zehra Tumoglu,1 Ronit Witztum,1 Soleil Wizman,1 Natan Kramskiy,1 Liah Igel,1 Fazilet Sen,1 Anna Ranzenigo,4 Anne Macdonald,1 Susan Hutchison,1 Abraham J.P. Teunissen,4 Heather Burkart,5 Mansi Saxena,1 Yelena Ginzburg,1 Ki Goosens,1 Weibin Zhou,1 Vitaly Ryu,1 Ofer Moldavski,1 Orly Barak,1 Michael Pazianas,1 John Caminis,1 Shalender Bhasin,6 Richard Fitzgerald,7 Se-Min Kim,1 Matthew Quinn,5 Shozeb Haider,8 Susan Appt,5 Tal Frolinger,1 Clifford J. Rosen,9 Daria Lizneva,1 Yogesh K. Gupta,2 Tony Yuen,1 and Mone [...]

UT Health San Antonio scientists uncover how some cancers outsmart immune system (Rao, Sung, Zheng, & Chen Labs)

July 17, 2025

 Shared By: Claire Kowalick July 17, 2025 FOXM1 protein identified as key driver in immunotherapy resistance, unlocking new therapeutic avenues   For years, scientists have found the overexpression of a specific protein called FOXM1 in a wide range of cancers, including ovarian, breast, and pediatric cancers. A recent study by scientists at The University of Texas [...]

Nature Communications: Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia (Bishop Lab)

June 3, 2025

 July Carolina Romero, Sonal S. Tonapi,Manish Parihar,Eva Loranc,Henry E. Miller,Liesl A. Lawrence,Nicklas Bassani,Daniel G. Robledo,Lin Cao,Jia Nie,Kairi Kanda,Aiola Stoja,Natalia Garcia,Aparna Gorthi,Brian J. Stoveken,Teresa W-M Fan,Teresa A. Cassel,Shan Zha,James D. Lechleiter,Nicolas Musi,Lily Q. Dong,Andrew N. Lane &Alexander J. R. Bishop Abstract Ataxia-telangiectasia is a rare genetic disorder characterized by neurological defects, immunodeficiency, cancer predisposition, radiosensitivity, decreased blood vessel [...]