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Greehey CCRI Core & Research Services (CRS)

Greehey CCRI Cores & Research Services (CRS) support hypothesis‑driven, translational research through high‑impact technologies and expert consultation across genomics, bioinformatics, functional genomics, drug response studies, and preclinical modeling. For more information about the GCCRI CRS or to request services, please visit the individual core websites listed below—don’t forget to bookmark the GCCRI CRS page.

Accelerating Discovery Through Advanced Research Technologies

The Greehey Children’s Cancer Research Institute (Greehey CCRI) at UT Health San Antonio provides a comprehensive portfolio of Core & Research Services designed to accelerate basic, translational, and clinical research. As one of only two institutes in the United States dedicated exclusively to pediatric cancer research, Greehey CCRI combines state-of-the-art technologies, expert scientific consultation, and collaborative partnerships to help investigators transform scientific questions into meaningful discoveries.

Integrated Research Support

Greehey CCRI Core & Research Services offer end-to-end support across the research continuum—from target identification and genomic profiling to preclinical validation and data analysis. Services are available to UT Health San Antonio investigators, academic collaborators, biotechnology companies, and pharmaceutical partners.

Core Service Areas

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Computational Biology
& Bioinformatics Initiative (CBBI)

Provides computational infrastructure, bioinformatics expertise, workflow development, statistical analysis, and systems biology support for large-scale datasets and complex genomic studies.

illustration of a human figure overlaid with strands of DNA, binary code 0s and 1s

Genome Sequencing Facility (GSF)

Delivers next-generation sequencing (NGS), single-cell analysis, and spatial transcriptomics using advanced platforms, including Illumina NovaSeq 6000, NextSeq 2000, 10x Genomics Chromium X, Visium HD, and Xenium technologies. Services include experimental design consultation, library preparation, sequencing, quality control, and bioinformatics support. Applications include RNA-seq, DNA-seq, epigenomics, CRISPR screening, single-cell multiomics, and spatial biology.

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Target Discovery Core (TDC)

Supports cancer therapeutic development through target identification and validation technologies, including CRISPR screening, gene editing, functional genomics, and drug testing platforms.

Xenograft & Cell-Lines (PDX)

Provides preclinical testing of chemotherapeutics and combination therapies using validated mouse models and patient-derived xenograft systems to accelerate translational research and therapeutic evaluation.

Hand in blue glove holding glass histology slides.

Histology

Offers tissue processing, sectioning, staining, and microscopic analysis support to enable detailed characterization of disease pathology and biomarker expression.

Mouse Radiation Treatment Center (MRTC)

Provides preclinical radiation research capabilities, including small-animal imaging, radiation treatment planning, and high-throughput evaluation of radiation-drug combination therapies.

Why Partner with Greehey CCRI?

  • Access to cutting-edge genomic, bioinformatics, and preclinical research technologies
  • Expert consultation for study design, grant development, and project execution
  • Collaborative and fee-for-service engagement models
  • Support for academic, government, biotechnology, and pharmaceutical research programs
  • Proven track record supporting cancer research across South Texas and beyond

Advancing Research. Accelerating Therapies.

Greehey CCRI Core & Research Services empower investigators with the tools, expertise, and collaborative environment needed to advance scientific discovery and translate research findings into tomorrow’s life-saving treatments. For more information, visit the Core & Research Services website at gccri.uthscsa.edu/services.

For more information, please contact each core director individually.