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Translating Today's Discoveries in Childhood Cancer Research into Tomorrow's Treatments.

The Greehey Children’s Cancer Research Institute is one of only two institutes in the United States exclusively focused on pediatric cancer research. With 18 laboratories, the institute leverages expertise in cancer genomics, DNA repair, RNA biology, and drug development to discover new and less harmful treatments for childhood cancers.

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Our research expertise spans cancer genomics, DNA damage, RNA biology, and drug development. We are also expanding our focus on drug delivery, particularly through nanotechnology-based methods for delivering small RNA mimics and inhibitors.

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Nature Communications

Nature Communications: Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer (Olsen, Wasmuth, Sung,)

Dr. Raushan Kurmasheva’s laboratory has been awarded a $400K NCI SBIR Phase II grant titled “Enhanced overall survival in high-risk pediatric tumors using a novel oral small molecule

Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex (Sung Lab, Rao Lab)

David Libich, PhD Awarded Five‑Year, $2.1 million NIH Grant to Study “Protein Intrinsic Disorder in Genome Regulation.”

News

  • Ubiquitylation of DNA polymerase β via atypical K27 chains signals a DNA damage response (Sung Lab)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • David Libich, PhD Awarded Five‑Year, $2.1 million NIH Grant to Study “Protein Intrinsic Disorder in Genome Regulation.”

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Journal of Biological Chemistry: Structural Basis for the Mechanism and Stability of the EEPD1 5’ Endonuclease (Gupta Lab)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Graduate School of Biomedical Sciences (GSBS) Outstanding Student Awards

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Drug Target Review: Why PARP inhibitors fail: key role of the CST complex in BRCA1-deficient cancers (Sung)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

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Events
Greehey CCRI Seminar Series: Wenshe Ray Liu, PhD (TX A&M)

Presentation title: “Targeting YEATS – An Epigenetic Reader Domain for Anti-Cancer Drug Discovery.”
Greehey CCRI Seminar Series: Lingtao Jin, PhD (UTHSA)
5th Annual Gear Up Against Kids Cancer Bike Ride

Signing up for the 5th Annual Gear Up Against Kids Cancer bike ride is a powerful way to support local childhood cancer research and turn your passion for cycling into a meaningful impact. Every dollar you raise helps fund essential research projects at the Greehey Children’s Cancer Research Institute – UT Health San Antonio, driving innovative studies and treatments that benefit children in our community fighting cancer.
Greehey CCRI Spring ’26 Seminar Series: Ratna K Vadlamudi, PhD (UTHSA)

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