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Translating Today's Discoveries in Childhood Cancer Research into Tomorrow's Treatments.

The Greehey Children’s Cancer Research Institute is one of only two institutes in the United States exclusively focused on pediatric cancer research. With 19 laboratories, the institute leverages expertise in cancer genomics, DNA repair, RNA biology, and drug development to discover new and less harmful treatments for childhood cancers.

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Our research expertise spans cancer genomics, DNA damage, RNA biology, and drug development. We are also expanding our focus on drug delivery, particularly through nanotechnology-based methods for delivering small RNA mimics and inhibitors.

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Nature Structural & Molecular Biology: Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation (Sung Lab, Hromas, Zhou, Zhao, Wasmuth, Olsen)

Nature Communications: HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination (Wasmuth, Zheng, Sung Lab, Zhao)

Nature Communications: Break-induced replication forms long mutable single-strand DNA during meiosis (Malkova)

Nature Communications: Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection (Sung Lab, Libich, Olsen, Wasmuth, Rao, et al)

News

  • 🎗️ THE SCIENCE BEHIND THE GOLD RIBBON: THE IGNATIUS LAB

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • CHILDHOOD CANCER AWARENESS MONTH: 🎗️ The Science Behind the Gold Ribbon: Gupta Lab

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Childhood Cancer Awareness Month: THE SCIENCE BEHIND THE GOLD RIBBON: THE CHEN LAB🎗️

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Nucleic Acids Research: Researchers Find a New Weak Spot in Cancer’s DNA Repair System (Olsen, Zhou, Sung Lab, Hromas)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Childhood Cancer Awareness Month: 🎗️THE SCIENCE BEHIND THE GOLD RIBBON: THE AUNE LAB

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

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Events
Greehey CCRI Seminar Series – Fall ’26: Jeanne Stachowiak, PhD (UT Austin)

Presentation title: Intrinsic Disorder as an Organizing Principle for Cellular Membranes
Greehey CCRI Spring ’26 Seminar Series: Reuben Harris, PhD (UTHSA)

Presentation title: “Progress on the development of novel drugs for viral proteases”
Greehey CCRI Seminar Series: Lingtao Jin, PhD (UTHSA)

Presentation title: “Kinase Signaling in Cancer Drug Resistance”
Greehey CCRI Seminar Series – Fall ’26 Elif Sarinay Cenik, PhD (UT Austin)

Presentation title: How Ribosome Nucleolar Defects Create Metabolic and Chromatin Vulnerabilities

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