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Our research expertise spans cancer genomics, DNA damage, RNA biology, and drug development. We are also expanding our focus on drug delivery, particularly through nanotechnology-based methods for delivering small RNA mimics and inhibitors.

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Nature Communications: Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer (Olsen, Wasmuth, Sung,)

Dr. Raushan Kurmasheva’s laboratory has been awarded a $400K NCI SBIR Phase II grant titled “Enhanced overall survival in high-risk pediatric tumors using a novel oral small molecule

Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer (Olsen Lab, Sung Lab)

Cancer Research: Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity (Rao, Zhou, Hromas, Sung, Chen, et al)

News

iScience: Predicting and interpreting protein and phosphoprotein abundance from pan-cancer and single-cell transcriptomes (Chen Lab)

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

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Nature Communications: Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer (Olsen, Wasmuth, Sung,)

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Congratulations to Elizabeth Wasmuth, PhD on Her UT Health SA Presidential Excellence Award

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Chemical Science: Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry (Olsen, Zhou)

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KABB TV (Fox SA) and WOAI-TV (NEWS4SA): Road to Gold — International Childhood Cancer Day celebrates perseverance of young patients

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Events

09 Jan

Greehey CCRI Spring Seminar Series: Min Kyu Kim, PhD, MS (UTHSA)

Presentation title: “Regulation of BRCA-1 Phosphorylation in Genome Repair.”

23 Jan

Greehey CCRI Spring Seminar Series: Uttiya Basu, PhD (Columbia)

Presentation title: Somatic Hypermutation Mechanisms in B-Cell Immunity and Cancer

06 Feb

Greehey CCRI Spring ’26 Seminar Series: Weixing “Wilson” Zhao, PhD (UTHSA)

20 Feb

Greehey CCRI Spring Seminar Series: James Haber, PhD (Brandeis Univ)

Presentation title: “Fidelity and infidelity in repairing broken chromosomes”

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