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Translating Today's Discoveries in Childhood Cancer Research into Tomorrow's Treatments.

The Greehey Children’s Cancer Research Institute is one of only two institutes in the United States exclusively focused on pediatric cancer research. With 18 laboratories, the institute leverages expertise in cancer genomics, DNA repair, RNA biology, and drug development to discover new and less harmful treatments for childhood cancers.

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In The News

Our research expertise spans cancer genomics, DNA damage, RNA biology, and drug development. We are also expanding our focus on drug delivery, particularly through nanotechnology-based methods for delivering small RNA mimics and inhibitors.

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Top stories

Trends in Biochemical Sciences: E3 Ubiquitin Ligases in Signaling, Disease, and Therapeutics (Olsen)

Dr. Raushan Kurmasheva’s laboratory has been awarded a $400K NCI SBIR Phase II grant titled “Enhanced overall survival in high-risk pediatric tumors using a novel oral small molecule

Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer (Olsen Lab, Sung Lab)

Cancer Research: Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity (Rao, Zhou, Hromas, Sung, Chen, et al)

News

  • SIOP 2026: Where Global Collaboration Meets Texas Hospitality

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • BioRxiv: High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for homologous recombination and olaparib response (Sung)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • 🚴‍♀️ Register Early & Save—Gear Up Against Kids Cancer Ride

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • Journal of Biological Chemistry: Phosphoregulation of RAD51AP1 function in homology-directed repair (Sung Lab)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

  • BioMolecules: The PELP1 Pathway and Its Importance in Cancer Treatment (Rao Lab)

    • Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

    Stay connected with the Greehey CCRI on Facebook, Twitter, LinkedIn, and Instagram.

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