Research Focus

Comparatively small numbers of children with cancer limit the definitive data from which to decide what benefits a novel anticancer agent may have in children. Hence, there is a need for pre-clinical models of childhood cancer to screen new agents’ potential activity in transgenic or xenograft animal and cell culture models.
The Pediatric Preclinical Testing Program (PPTP) is a comprehensive program to systematically evaluate new agents against childhood solid tumor and leukemia models. The PPTP is supported through an NCI research contract to The Research Institute at Nationwide Children’s Hospital with Dr. Peter Houghton as the Principal Investigator.
As part of their professional curriculum, students in the Doctor of Optometry program learn to conduct comprehensive pediatric eye exams and assess retinoblastoma. Optometry students from the Summer Fellowship Training Program at the Rosenberg School of Optometry (UIW) participate in a collaborative research project with the Greehey Children’s Cancer Research Institute to investigate retinoblastoma’s molecular basis.
The purpose of the Greehey Children’s Cancer Research Institute’s (Greehey CCRI) Undergraduate Summer Internship Program is to allow talented undergraduate students interested in a career in academic research the opportunity to spend approximately ten weeks during the summer conducting hypothesis-driven research in childhood cancer in one of the laboratories at the Greehey Children’s Cancer Research Institute.
In collaboration with the Kids With Cancer Foundation of Vietnam, our team members evaluated institutional capabilities and any possible impact of program implementation. We found that in southern Vietnam, cancer survival was estimated as low as 5% compared to more than 90% survival for childhood ALL in the USA. Our current efforts focus on exposing and educating Vietnamese physicians on new diagnoses and management techniques.