Cancer Research: IGFBP7 Deletion Promotes Hepatocellular Carcinoma

August 1, 2017

Maaged Akiel, Chunqing Guo, Xia Li, Devaraja Rajasekaran, Rachel G. Mendoza, Chadia L. Robertson, Nidhi Jariwala, Fang Yuan, Mark A. Subler, Jolene Windle, Dawn K. Garcia, Zhao Lai, Hung-I Harry Chen, Yidong Chen, Shah Giashuddin, Paul B. Fisher, Xiang-Yang Wang and Devanand Sarkar Abstract Activation of IGF signaling is a major oncogenic event in diverse cancers, including hepatocellular carcinoma (HCC). In this setting, the insulin-like growth factor-binding protein IGFBP7 inhibits IGF signaling by binding the IGF1 receptor (IGF1R), functioning as a candidate tumor suppressor. IGFBP7 abrogates tumors by inhibiting angiogenesis and […]

PLOS One: Target specificity, “in vivo” pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing’s sarcoma, and rhabdomyosarcoma

July 27, 2017

Peter Y. Yu , Heather L. Gardner , Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K. LeBlanc, Hui Xiao, Jiayuh Lin, Denis C. Guttridge, Xiaokui Mo, Chad E. Bennett, Christopher C. Coss, Yonghua Ling, Mitch A. Phelps, Peter Houghton, Cheryl A. London  Abstract Background STAT3 is a transcription factor involved in cytokine and receptor kinase […]

Clinical Cancer Research: Bioluminescence Imaging Enhances Analysis of Drug Responses in a Patient-Derived Xenograft Model of Pediatric ALL

July 15, 2017

Luke Jones 1, Jennifer Richmond 1, Kathryn Evans 1, Hernan Carol 1, Duohui Jing 1, Raushan T Kurmasheva 2, Catherine A Billups 3, Peter J Houghton 2, Malcolm A Smith 4, Richard B Lock 5 Abstract Purpose: Robust preclinical models of pediatric acute lymphoblastic leukemia (ALL) are essential in prioritizing promising therapies for clinical assessment in high-risk patients. Patient-derived xenograft (PDX) models of ALL provide a clinically relevant platform for assessing novel drugs, with […]

Clinical Cancer Research: Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood

July 1, 2017

Maria Isabel Achatz, Christopher C. Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D. Foulkes, Christian P. Kratz, Roland P. Kuiper, Jordan R. Hansford, Hector Salvador Hernandez, Katherine L. Nathanson, Wendy K. Kohlmann, Leslie Doros, Kenan Onel, Kami Wolfe Schneider, Sarah R. Scollon, Uri Tabori, Gail E. Tomlinson, D. Gareth R. Evans and Sharon E. Plon Abstract Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in […]

Clinical Cancer Research: Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma

July 1, 2017

Jennifer M Kalish 1, Leslie Doros 2, Lee J Helman 3, Raoul C Hennekam 4, Roland P Kuiper 5, Saskia M Maas 6, Eamonn R Maher 7, Kim E Nichols 8, Sharon E Plon 9, Christopher C Porter 10, Surya Rednam 9, Kris Ann P Schultz 11, Lisa J States 12, Gail E Tomlinson 13, Kristin Zelley 14, Todd E Druley 15 Abstract A number of genetic syndromes have been linked to increased risk for Wilms tumor (WT), hepatoblastoma (HB), and other embryonal tumors. Here, we […]

Clinical Cancer Research: Multiple Endocrine Neoplasia and Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood

July 1, 2017

Jonathan D Wasserman 1, Gail E Tomlinson 2, Harriet Druker 3, Junne Kamihara 4, Wendy K Kohlmann 5, Christian P Kratz 6, Katherine L Nathanson 7, Kristian W Pajtler 8 9, Andreu Parareda 10, Surya P Rednam 11, Lisa J States 12, Anita Villani 3, Michael F Walsh 13, Kristin Zelley 14, Joshua D Schiffman 15 Abstract Children and adolescents who present with neuroendocrine tumors are at extremely high likelihood of having an underlying germline predisposition for the multiple endocrine neoplasia (MEN) syndromes, including MEN1, […]

Cell Report: The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma

June 13, 2017

Myron S Ignatius 1, Madeline N Hayes 2, Riadh Lobbardi 2, Eleanor Y Chen 3, Karin M McCarthy 4, Prethish Sreenivas 5, Zainab Motala 6, Adam D Durbin 7, Aleksey Molodtsov 4, Sophia Reeder 4, Alexander Jin 4, Sivasish Sindiri 8, Brian C Beleyea 9, Deepak Bhere 10, Matthew S Alexander 11, Khalid Shah 9, Charles Keller 12, Corinne M Linardic 8, Petur G Nielsen 13, David Malkin 6, Javed Khan 8, David M Langenau 14 Abstract Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are […]

Hepatology: A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH)

June 13, 2017

Jyoti Srivastava 1, Chadia L Robertson 1, Kareem Ebeid 2, Mikhail Dozmorov 3, Devaraja Rajasekaran 1, Rachel Mendoza 1, Ayesha Siddiq 1, Maaged A Akiel 1, Nidhi Jariwala 1, Xue-Ning Shen 1, Jolene J Windle 1, Mark A Subler 1, Nitai D Mukhopadhyay 3, Shah Giashuddin 4, Shobha Ghosh 5, Zhao Lai 6, Yidong Chen 7, Paul B Fisher 1 8 9, Aliasger K Salem 2 10, Arun J Sanyal 5, Devanand Sarkar 1 8 9 Abstract Nonalcoholic steatohepatitis (NASH) is the most prevalent cause of chronic liver disease in the Western world. However, an optimum therapy for NASH is yet […]

JAMA Oncology: Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era: A Correlative Analysis Based on NRG Oncology RTOG 0525

June 1, 2017

Erica Hlavin Bell 1, Stephanie L Pugh 2, Joseph P McElroy 3, Mark R Gilbert 4, Minesh Mehta 5, Alexander C Klimowicz 6, Anthony Magliocco 7, Markus Bredel 8, Pierre Robe 9, Anca-L Grosu 10, Roger Stupp 11, Walter Curran Jr 12, Aline P Becker 1, Andrea L Salavaggione 1, Jill S Barnholtz-Sloan 13, Kenneth Aldape 14, Deborah T Blumenthal 15, Paul D Brown 14, Jon Glass 16, Luis Souhami 17, R Jeffrey Lee 18, David Brachman 19, John Flickinger 20, Minhee Won 2, Arnab Chakravarti 1 Abstract Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in […]

Aging Cell: Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health

May 29, 2017

Ning Zhang 1, Joseph M Valentine 1, You Zhou 1, Mengyao E Li 1 2, Yiqiang Zhang 1, Arunabh Bhattacharya 1, Michael E Walsh 1, Katherine E Fischer 1, Steven N Austad 1, Pawel Osmulski 1, Maria Gaczynska 1, Steven E Shoelson 2, Holly Van Remmen 1, Hung I Chen 3 4, Yidong Chen 3 4, Hanyu Liang 1, Nicolas Musi 1 5 Abstract Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic. Nonetheless, the mechanisms underlying these aging-related metabolic disorders are unknown. NFκB has been implicated in […]