Greehey CCRI Seminar Series, Spring ’23: Feng Yue, PhD – Northwestern Univ
Event Date & TimeApril 7, 2023 at 12:00N -1:00P
LocationGreehey CCRI Auditorium (2.160)
Presentation Title: TBD
Greehey CCRI Hosts: Siyuan Zheng, PhD, Myron Ignatius, PhD,
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About the Speaker(s)
The long-term goal of Dr. Yue's group is to use a combination of high-throughput genomics, computational modeling, and functional assays to study how genetic variants contribute to the pathogenesis of human cancer. In particular, he is interested in identifying the mutations that can disrupt the function of non-coding regulatory elements such as enhancers and further influence the 3D organization of the human genome. He has been actively involved with several large NIH-funded consortia and led the overall analysis effort for the mouse ENCODE consortium (Yue et al. Nature 2014). More recently, his group and their collaborators show that Hi-C can be used as a tool for the systematic discovery of SVs in the genome and also reported widespread neo-TADs and enhancer hijacking events, which potentially contribute to gene misregulation in cancer cells. The eventual goal for Dr. Yueâs research is to reveal the key cancer-specific or subtype-specific regulators and pathways, which can be potentially used as cancer biomarkers and therapeutic targets.