Greehey CCRI Seminar Series, Spring ’23: Ming-Ming Zhou, PhD – Icahn School of Med at Mount Sinai
Event Date & TimeFebruary 24, 2023 at 12:00N -1:00P
LocationGreehey CCRI Auditorium (2.160)
Presentation title: TBD
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About the Speaker(s)
The research in the Zhou Lab is directed at a better understanding of the biology of epigenetic control of gene expression of the human genome to attain both mechanistic insights and rational design of small-molecule ligands that modulate gene expression. The emphasis is on chromatin's chemical modifications in controlling gene transcription (such as acetylation and methylation). Towards this end, we are developing an interdisciplinary epigenomics research paradigm that is built upon an integrated approach of structural and chemical biology and molecular/cell chromatin biology. To understand epigenetic gene regulation at the fundamental molecular level, we simultaneously conduct interdependent research in (1) Family-wide functional profiling of proteins in chromatin modifications and molecular interactions; (2) Structure-based functional design of small-molecule chemical probes for transcription-associated proteins; and (3) Chemical epigenomics study of histone-directed chromatin biology in health and disease.