Greehey CCRI Seminar Series, Spring ’24:Alberto Ciccia, PhD (Columbia University)
Event Date & Time
April 5, 2024 at 12:00PLocation
Greehey CCRI Auditorium (2.160)About the Speaker(s)
Dr. Ciccia’s laboratory is interested in elucidating the mechanisms by which the DNA damage response (DDR) operates to maintain genome integrity. The DDR plays a critical role in human disease, and mutations in DDR genes cause more than 40 genetic disorders affecting the development of nervous, reproductive, and immune systems and predisposing individuals to premature aging and cancer (Ciccia and Elledge, Mol Cell, 2010). During his previous studies, Dr. Ciccia identified and characterized five novel DNA repair factors that prevent the development of cancer and genetic disorders, including the DNA nucleases EME1 and EME2, the Fanconi anemia-associated protein FAAP24, the Schimke immuno-osseous dysplasia protein SMARCAL1 and its related factor ZRANB3 (Ciccia et al, Mol Cell, 2007; Ciccia et al, Genes Dev, 2009; Ciccia et al, Mol Cell, 2012). Dr. Ciccia is currently utilizing biochemical and genetic tools to identify novel components of the DDR.