Frontiers: Editorial -Antioxidants in Mitigating Oxidative Stress-Induced Damage (Aune Lab)

January 8, 2026

Marisol Fernandez-Ortiz 1* Ramy K. A. Sayed 2 Russel J. Reiter 3 Editorial on the Research Topic: Antioxidants in mitigating oxidative stress-induced damage Oxidative stress arises from an imbalance between the generation of reactive oxygen species (ROS) and the antioxidant defenses that normally maintain redox homeostasis. When ROS accumulate in excess, they damage lipids, proteins, and nucleic acids, [...]

Journal of Applied Physiology: Evaluating the effects of exercise and phellodendron amurense on cardiac function in a prostate cancer mouse model (Aune Lab)

August 4, 2025

Neha Kumar, Logan R. Davis, Gregory J. Aune Paul Rivas, Addanki P. Kumar, Darpan I. Patel Abstract Cytotoxic treatments pose a significant cardiotoxic risk to men with prostate cancer (PCa). Exercise has been found to prevent cardiotoxicities. Previous work from our group has also identified the chemopreventative effects of phellodendron amurense (PhAm). We therefore aimed [...]

Int’l Journal of Molecular Sciences: The Role of the Tumor Microenvironment (TME) in Advancing Cancer Therapies: Immune System Interactions, Tumor-Infiltrating Lymphocytes (TILs), and the Role of Exosomes and Inflammasomes (Aune Lab)

March 28, 2025

by, Atef M. Erasha Hanem EL-Gendy  Ahmed S. Aly  Marisol Fernández-Ortiz Ramy K. A. Sayed Abstract Understanding how different contributors within the tumor microenvironment (TME) function and communicate is essential for effective cancer detection and treatment. The TME encompasses all the surroundings of a tumor, such as blood vessels, fibroblasts, immune cells, signaling molecules, exosomes, [...]

JNCI Cancer Spectrum: Neighborhood-level social determinants of health burden among adolescent and young adult cancer patients and impact on overall survival (Aune)

September 3, 2024

Elizabeth R Rodriguez, BS, Tori Tonn, BS, Midhat Jafry, BS, Sairah Ahmed, MD, Branko Cuglievan, MD, J Andrew Livingston, MD, Christopher R Flowers, MD, Gregory J Aune, MD, PhD, Karen H Albritton, MD, Michael E Roth, MD, Qian Xiao, PhD, Michelle A T Hildebrandt, PhD Abstract Background Neighborhood socioeconomic deprivation has been linked to adverse health outcomes, yet it is unclear whether neighborhood-level social determinants of [...]

JNCI Cancer Spectrum: Neighborhood-level Social Determinants of Health Burden among AYA Cancer Patients and Impact on Overall Survival (Aune)

July 29, 2024

Elizabeth R Rodriguez, B.S, Tori Tonn, B.S, Midhat Jafry, B.S, Sairah Ahmed, M.D, Branko Cuglievan, M.D, J Andrew Livingston, M.D, Christopher R Flowers, M.D, Gregory J Aune, M.D., Ph.D, Karen H Albritton, M.D, Michael E Roth, M.D, Qian Xiao, Ph.D, Michelle A T Hildebrandt, Ph.D Abstract Purpose Neighborhood socioeconomic deprivation has been linked to adverse health outcomes. Yet, it is unclear if neighborhood-level social determinants [...]

Texas Public Radio: “Fighting childhood cancer in San Antonio” (Aune)

September 8, 2023

September is Childhood Cancer Awareness Month, a time to raise awareness of this devastating disease and to support the children and families who are affected by it. Childhood cancer is the leading cause of death by disease for children under the age of 14. Each year, about 15,000 children in the United States are diagnosed [...]

Journal of Clinical Oncology: The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer (Aune Co-author)

June 5, 2023

Joseph A. Flores-Toro  , PhD1; Subhashini Jagu  , PhD1; Gregory T. Armstrong, MD, MSCE2; David F. Arons, JD3; Gregory J. Aune, MD, PhD4; Stephen J. Chanock  , MD1; Douglas S. Hawkins  , MD5; Allison Heath  , PhD6; Lee J. Helman  , MD7; Katherine A. Janeway  , MD, MMSc8; Jason E. Levine  , MD1; Ellyn Miller, [...]

Thrombosis Research: A cohort study on blood coagulation in childhood cancer survivors (Aune)

May 5, 2023

                  Andrew D. Meyer a, Tyler B. Hughes a, Anjana R. Rishmawi a, Patty Heard a, Shafqat Shah b, Gregory J. Aune b c Highlights Anticoagulants decrease thrombotic events in adults receiving cancer therapy. Survivors of childhood cancer have an increased risk of a thromboembolic stroke. Elevated coagulation protein levels are sensitive biomarkers of thrombosis risk. Our study identified that childhood survivors have chronically elevated [...]

American Journal of Heart & Circulatory Physiology: Development and Characterization of a Mass Cytometry Panel for Detecting the Effect of Acute Doxorubicin Exposure on Murine Cardiac Non-myocytes (Bishop, Chen, & Aune Labs)

June 8, 2022

Brian S. Iskra, Logan R. Davis, Henry E. Miller, Yu-Chiao Chiu, Alexander J.R. Bishop, Yidong Chen, and Gregory J. Aune Abstract Childhood cancer survivors (CCSs) face lifelong side effects related to their treatment with chemotherapy. Anthracycline agents, such as doxorubicin (DOX), are important in the treatment of childhood cancers but are associated with cardiotoxicity. Cardiac toxicities represent a significant source [...]

Salud America: Gregory Aune: The Gear Up Against Kids Cancer Bike Ride

March 15, 2022

                  Original post: Salud America "Gregory Aune was 16 when he was diagnosed with Hodgkin’s Lymphoma. Aune spent a year enduring grueling treatment, losing over 70 pounds. But he survived. His experience motivated him to pursue a clinical career and help children with cancer. Today, Dr. Aune is an [...]