Nucleic Acids Research: Exploration and analysis of R-loop mapping data with RLBase (Bishop Lab)

August 30, 2022

Henry E Miller, Daniel Montemayor, Janet Li, Simon A Levy, Roshan Pawar, Stella Hartono, Kumar Sharma, Bess Frost, Frédéric Chedin, Alexander J R Bishop Abstract R-loops are three-stranded nucleic acid structures formed from the hybridization of RNA and DNA. In 2012, Ginno et al. introduced the first R-loop mapping method. Since that time, dozens of R-loop mapping studies have been conducted, yielding hundreds of publicly available [...]

Non-Coding RNA: Systematic Analysis of Long Non-Coding RNA Genes in Nonalcoholic Fatty Liver Disease (Bishop Lab)

July 27, 2022

Mirolyuba Ilieva James Dao Henry E. Miller Jens Hedelund Madsen Alexander J. R. Bishop Sakari Kauppinen Shizuka Uchida   Abstract The largest solid organ in humans, the liver, performs a variety of functions to sustain life. When damaged, cells in the liver can regenerate themselves to maintain normal liver physiology. However, some damage is beyond [...]

Nucleic Acids Research: Quality-controlled R-loop meta-analysis reveals the characteristics of R-loop consensus regions (Bishop Lab)

June 27, 2022

Henry E Miller, Daniel Montemayor, Jebriel Abdul, Anna Vines, Simon A Levy, Stella R Hartono, Kumar Sharma, Bess Frost, Frédéric Chédin, Alexander J R Bishop Abstract R-loops are three-stranded nucleic acid structures formed from the hybridization of RNA and DNA. While the pathological consequences of R-loops have been well-studied to date, the locations, classes, and [...]

American Journal of Heart & Circulatory Physiology: Development and Characterization of a Mass Cytometry Panel for Detecting the Effect of Acute Doxorubicin Exposure on Murine Cardiac Non-myocytes (Bishop, Chen, & Aune Labs)

June 8, 2022

Brian S. Iskra, Logan R. Davis, Henry E. Miller, Yu-Chiao Chiu, Alexander J.R. Bishop, Yidong Chen, and Gregory J. Aune Abstract Childhood cancer survivors (CCSs) face lifelong side effects related to their treatment with chemotherapy. Anthracycline agents, such as doxorubicin (DOX), are important in the treatment of childhood cancers but are associated with cardiotoxicity. Cardiac toxicities represent a significant source [...]

Non-Coding RNA: Current Status of Epitranscriptomic Marks Affecting lncRNA Structures and Functions (Bishop Lab)

April 22, 2022

by Henry E. Miller 1,2,3ORCID, Mirolyuba Ilieva 4, Alexander J. R. Bishop 1,2,5ORCID and Shizuka Uchida 4, Non-Coding RNA 2022, 8(2), 23; https://doi.org/10.3390/ncrna8020023 Received: 1 March 2022 / Revised: 21 March 2022 / Accepted: 25 March 2022 / Published: 28 March 2022 Abstract Long non-coding RNAs (lncRNAs) belong to a class of non-protein-coding RNAs with [...]

Non-Coding RNA, FibroDB: Expression Analysis of Protein-Coding and Long Non-Coding RNA Genes in Fibrosis (Bishop Lab)

February 25, 2022

by Mirolyuba Ilieva 1ORCID,Henry E. Miller 2,3,4ORCID,Arav Agarwal 4,5,Gabriela K. Paulus 4,6,Jens Hedelund Madsen 1,Alexander J. R. Bishop 2,3,7ORCID,Sakari Kauppinen 1 and Shizuka Uchida 1,*ORCID Abstract Most long non-coding RNAs (lncRNAs) are expressed at lower levels than protein-coding genes and their expression is often restricted to specific cell types, certain time points during development, and [...]

Free Radical Biology and Medicine: Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer (Bishop Lab)

October 26, 2021

MarinaDelgoboa  Rosângela MayerGonçalvesag  Marco AntônioDelazerib  MarceloFalchettia  AlessandroZandonáb  RaquelNascimento das Nevesa  KarolineAlmeidaa  Adriane CristinaFagundesa  Daniel PensGelainc  João IsidroFracassod  Guilherme Baroni deMacêdod  LeonardoPriorid  NicklasBassanie  Alexander James RoyBishopef  Cassiano MateusForcelinib  José Cláudio FonsecaMoreirac1  AlfeuZanotto-Filhoa1 Highlights • Amid 64 redox genes, TXNRD1 shows association with poor survival in NSCLC. • High TXNRD1 levels predict poor DFS and DMFS in [...]

PIPETTE GAZETTE – Meet The Researcher: Aiola Stoja and her love for dogs, hiking and cancer research (Bishop Lab)

October 22, 2021

While Aiola Stoja Payne was volunteering as an emergency medical technician (EMT), she learned about a new substance that was just being implemented in emergency medicine. She was taught that this substance was a powder that you put directly on the wound site and was more helpful than just gauze alone to help with bleeding. [...]

BRCA2 Promotes Spontaneous Homologous Recombination In Vivo (Bishop)

August 9, 2021

Adam D. Brown, Scott Greenman, Alison B. Claybon, Alexander J. R. Bishop Simple Summary Inherited mutation of either BRCA1 or BRCA2 is associated with familial breast and ovarian cancer. As a tumor suppressor, BRCA2 functions to maintain genome stability but we do not know the genomic impact of this deficiency on normal tissues in normal contexts, rather than […]

Henry Miller (Bishop Lab) Receives NIA F31 Fellowship Award

August 6, 2021

Congrats to Henry Miller (Mentor: Alexander Bishop, D. Phil.) on recently being awarded a Ruth L. Kirschstein Predoctoral Individual National Research Service Award ,NIA F31 fellowship! We asked Henry to tell us more about the project he will be leading and how it will affect his future as a researcher. What is the general scope […]