May 20, 2016
The Greehey Children’s Cancer Research Institute at the Health Science Center garnered $10.9 million from the Cancer Prevention & Research Institute of Texas (CPRIT)―a larger amount than any other academic institution in the state. The Health Science Center received 24 percent of the $45.3 million awarded to 13 academic institutions on May 18. The grant was the […]
May 18, 2016
Raushan T. Kurmasheva & Peter J. Houghton Abstract In the USA, the overall cure rate for all childhood cancers is seventy percent, and in many patients that ultimately fail curative therapy, initial responses to current multimodality treatments (surgery, radiation therapy, and chemotherapy) are good, with overall 5-year event-free survival approaching 80 %. However, current approaches to curative […]
May 15, 2016
Hemant K Bid 1, Doris A Phelps 1, Linlin Xaio 1, Denis C Guttridge 2, Jiayuh Lin 1, Cheryl London 3, Laurence H Baker 4, Xiaokui Mo 5, Peter J Houghton 6 Abstract The bromodomain and extra-terminal domain inhibitor JQ1 has marked antitumor activity against several hematologic malignancies as well as solid tumor models. Here, we investigated its activity in vitro and in vivo against models of childhood rhabdomyosarcoma and Ewing sarcoma. […]
April 17, 2016
Michelle L. Churchman,1 Kathryn Evans,2 Jennifer Richmond,2 Alissa Robbins,2 Luke Jones,2 Irina M. Shapiro,3 Jonathan A. Pachter,3 David T. Weaver,3 Peter J. Houghton,4 Malcolm A. Smith,5 Richard B. Lock,2 and Charles G. Mullighan1 Abstract BCR-ABL1+ B progenitor acute lymphoblastic leukemia (Ph+ B-ALL) is an aggressive disease that frequently responds poorly to currently available therapies. Alterations in IKZF1, which encodes the lymphoid transcription factor Ikaros, are present in over 80% of […]
March 1, 2016
Richard Gorlick 1, E Anders Kolb 2, Stephen T Keir 3, John M Maris 4, Richard B Lock 5, Hernan Carol 5, C Patrick Reynolds 6, Min H Kang 6, Catherine A Billups 7, Jerry Collins 8, Dias Kurmashev 9, Raushan T Kurmasheva 9, Peter J Houghton 9, Malcolm A Smith 10 Abstract Background: NSC 750854 is a purine analog with an antitumor activity profile distinctive from that of other anticancer purines. It has shown significant activity against adult cancer preclinical models. Procedure: NSC […]
February 1, 2016
Edward F Attiyeh, John M Maris 1, Richard Lock 2, C Patrick Reynolds 3, Min H Kang 3, Hernan Carol 2, Richard Gorlick 4, E Anders Kolb 5, Stephen T Keir 6, Jianrong Wu 7, Yosef Landesman 8, Sharon Shacham 8, Dmitry Lyalin 9, Raushan T Kurmasheva 9, Peter J Houghton 9, Malcolm A Smith 10 Abstract Background: Selinexor (KPT-330) is an inhibitor of the major nuclear export receptor, exportin 1 (XPO1, also termed chromosome region maintenance 1, CRM1) that has demonstrated activity in preclinical models […]
December 1, 2015
Amelie Forest 1, Michael Amatulli 1, Dale L Ludwig 1, Christopher B Damoci 1, Ying Wang 1, Colleen A Burns 1, Gregory P Donoho 2, Nina Zanella 3, Heinz H Fiebig 3, Marie C Prewett 1, David Surguladze 1, James T DeLigio 1, Peter J Houghton 4, Malcolm A Smith 5, Ruslan Novosiadly 6 Abstract Despite a recent shift away from anti-insulin-like growth factor I receptor (IGF-IR) therapy, this target has been identified as a key player in the resistance mechanisms to various conventional […]
November 7, 2015
David J. Elzi1, Meihua Song1, Peter J. Houghton1,2,3, Yidong Chen1,2,4, and Yuzuru Shiio1,2,5 ABSTRACT Ewing sarcoma is a cancer of the bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family transcription factor, most commonly FLI-1. The EWS-FLI-1 fusion oncogene is widely believed to play a central […]
October 10, 2015
Addressing the relatively small number of new cancer drugs for children, a selective group of leading research centers is joining a new federally funded research consortium aimed at bringing scientific rigor and a concentrated effort to identifying new drug candidates for pediatric clinical trials. The Children’s Hospital of Philadelphia (CHOP) and four other high-profile oncology […]
October 1, 2015
Adam Studebaker 1, Kathryn Bondra 2, Star Seum 2, Changxian Shen 1, Doris A Phelps 1, Christopher Chronowski 2, Justin Leasure 2, Paul D Smith 3, Raushan T Kurmasheva 1, Xiaokui Mo 4, Maryam Fouladi 5, Peter J Houghton 1 Abstract Purpose: Curative therapy for childhood glioma presents challenges when complete resection is not possible. Patients with recurrent low-grade tumors or anaplastic astrocytoma may receive radiation treatment; however, the long-term sequelae from radiation treatment can be severe. As many […]