September 1, 2015
Dr. Peter Houghton, Dr. Raushan Kurmasheva (Co-Investigator) Dr. Houghton is the Director of the Greehey Children’s Cancer Research Institute, which has as its mission to advance scientific knowledge relevant to childhood cancer and to accelerate the translation of knowledge into novel therapies. Dr. Houghton has been a leader in evaluating experimental agents using childhood […]
September 1, 2015
Gary M Woods # 1, Kathryn Bondra # 2, Christopher Chronowski 2, Justin Leasure 2, Mamata Singh 2, Lauren Hensley 2, Timothy P Cripe 1, Arnab Chakravarti 2, Peter Houghton 1 Abstract Background: We previously determined that radiation could be safely administered using a mouse-flank in vivo model to both alveolar (Rh30) and embryonal (Rh18) rhabdomyosarcoma xenografts. Mice from both tumor lines in this experiment developed metastases, an event not previously described with these models. […]
August 26, 2015
Over the past 35 years, cure rates for pediatric cancers have increased dramatically. However, it is clear that further dose intensification using cytotoxic agents or radiation therapy is not possible without enhancing morbidity and long-term effects. Consequently, novel, less genotoxic, agents are being sought to complement existing treatments. Here, we discuss preclinical human tumor xenograft […]
April 1, 2014
Danhan Wang, Hui Gao, Abhik Bandyopadhyay, Anqi Wu, I-Tien Yeh, Yidong Chen, Yi Zou, Changjiang Huang, Christi A. Walter, Qiaoxiang Dong, and Lu-Zhe Sun Abstract Perinatal exposure to bisphenol A (BPA) has been shown to cause aberrant mammary gland morphogenesis and mammary neoplastic transformation. Yet, the underlying mechanism is poorly understood. We tested the hypothesis that mammary glands exposed to BPA during a susceptible window may lead to its susceptibility to tumorigenesis through a stem cell-mediated mechanism. […]