eLife: tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

September 7, 2018

Myron S Ignatius, Madeline N Hayes, Finola E Moore, Qin Tang, Sara P Garcia, Patrick R Blackburn, Kunal Baxi, Long Wang, Alexander Jin, Ashwin Ramakrishnan, Sophia Reeder, Yidong Chen, Gunnlaugur Petur Nielsen, Eleanor Y Chen, Robert P Hasserjian, Franck Tirode, Stephen C Ekker, David M Langenau  Abstract The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germline inactivation are predisposed to developing cancer. Here, we generated tp53 deleted […]

Cell Stem Cell: Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma

March 1, 2018

Madeline N Hayes 1, Karin McCarthy 1, Alexander Jin 1, Mariana L Oliveira 2, Sowmya Iyer 1, Sara P Garcia 1, Sivasish Sindiri 3, Berkley Gryder 3, Zainab Motala 4, G Petur Nielsen 5, Jean-Paul Borg 6, Matt van de Rijn 7, David Malkin 4, Javed Khan 3, Myron S Ignatius 8, David M Langenau 9 Abstract Tumor growth and relapse are driven by tumor propagating cells (TPCs). However, mechanisms regulating TPC fate choices, maintenance, and self-renewal are not fully understood. Here, we show that Van […]

UT Health SA Newsroom: Greehey Institute begins 2018 with new faculty studying children’s cancer

January 18, 2018

The Greehey Children’s Cancer Research Institute at UT Health San Antonio is on an impressive and rising trajectory as 2018 begins. This includes the recruitment of seven new faculty members, further bolstering the Alamo City’s thriving biosciences sector. Extramural funding for the Greehey Institute totaled $11.1 million in the state fiscal year ending Aug. 31, […]

WQAD: YOUR HEALTH: A fish that could help treat cancer

January 8, 2018

SAN ANTONIO, Texas – It all started in May. Kennedie Bailey was a healthy, happy fifth-grader when doctors diagnosed her with rhabdomyosarcoma, a rare form of childhood cancer. “He did a biopsy and then a few weeks later, we found out the results and that’s how we learned that I had rhabdomyosarcoma,” she remembered.

WFMZ: Health Beat: Kennedie and zebrafish fight cancer together

December 22, 2017

Kennedie Bailey was a healthy, happy fifth grader until this past summer, when doctors diagnosed her with rhabdomyosarcoma; a rare form of childhood cancer. “He did a biopsy, and then a few weeks later, we found out the results, and that’s how we learned that I had rhabdomyosarcoma,” Kennedie recalled.

WDNU: Cancer researchers turn to small fish to save lives

December 15, 2017

Zebrafish are rapidly becoming the ‘go-to’ animals in cancer research. Small and translucent, they breed rapidly and take up little room. But most important; they grow transplanted cancer tumors in their little bodies very quickly. This gives doctors a clear view of why some cancers metastasize and recur.

Ivanhoe Network: Kennedie and Zebrafish Fight Cancer Together

December 14, 2017

SAN ANTONIO, Texas. (Ivanhoe Newswire) — Zebrafish are rapidly becoming the ‘go-to’ animals in cancer research. Small and translucent, they breed rapidly, and take up little room. But most important; they grow transplanted cancer tumors in their little bodies very quickly. This gives doctors a clear view of why some cancers metastasize and recur. Eventually, […]

WJMN: Fighting cancer

December 14, 2017

Zebrafish are small and translucent. But most important; they grow transplanted cancer tumors very quickly. This gives doctors a clear view of why some cancers metastasize and recur. Eventually, this research will yield treatment for these recurrent cancers, which can be deadly. Kennedie Bailey was a healthy, happy fifth-grader until this past summer when doctors diagnosed her […]

9&10 News: Healthy Living: Zebrafish Fighting Cancer (Ignatius Lab)

December 13, 2017

Zebrafish are quickly becoming the ‘go-to’ animals in cancer research. Small and translucent, they breed rapidly and take up little room, but most importantly they grow transplanted cancer tumors in their little bodies very quickly, helping doctors learn about the disease.