Cell Reports: TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis (Vaseva Lab, Sung)

January 12, 2024

Teresa Marple 1 4 8, Mi Young Son 1 2 5 8, Xiaodong Cheng 1 6, Jun Ho Ko 1 7, Patrick Sung 2 3 4, Paul Hasty 1 3 5 9 Highlights The 3′-5′ exonuclease TREX2 causes spontaneous mutations in cells TREX2 causes mutations in cells exposed to a range of genotoxins TREX2 causes spontaneous mutations in MMR-deleted cells Deletion of TREX2 and MMR has a synthetic effect on DNA replication Summary TREX2, a 3′-5′ exonuclease, is a part of the DNA damage tolerance (DDT) [...]

Angelina Vaseva, PhD to Receive Department of Defense Neurofibromatosis Research Program New Investigator Award

April 25, 2023

Abstract Neurofibromatosis type 1 (NF1) -associated malignant peripheral nerve sheath tumor is the leading cause of death in patients with NF1 syndrome. It is a highly aggressive soft-tissue sarcoma with very limited therapy options due to resistance to conventional therapies as well as a metastatic propensity. There is an urgent need for novel and more [...]

Angelina Vaseva, PhD to Receive NCI Method to Extend Research in Time (MERIT)(R37) Award.

March 2, 2022

Angelina Vaseva, PhDAssistant Professor,Department of Molecular Medicine,Greehey Children’s Cancer Research Institute Congratulations to Dr. Vaseva on being awarded an NCI Method to Extend Research in Time (MERIT)(R37) Award. NCI R37 award provides longer-term grant support to Early Stage Investigators (ESIs) that receive outstanding R01 grant scores. Eligible investigators may obtain up to seven years of [...]