Cell Chemical Biology: MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome

May 1, 2020

ZhiJun Qiu 1, An-Ping Lin 1, Shoulei Jiang 1, Sara M Elkashef 1, Jamie Myers 1, Subramanya Srikantan 2, Binu Sasi 1, John Z Cao 3, Lucy A Godley 3, Dinesh Rakheja 4, Yingli Lyu 5, Siyuan Zheng 6, Muniswamy Madesh 2, Yuzuru Shiio 7, Patricia L M Dahia 1, Ricardo C T Aguiar 8 Abstract Mitochondrial D2HGDH and L2HGDH catalyze the oxidation of D-2-HG and L-2-HG, respectively, into αKG. This contributes to cellular homeostasis in part by modulating the activity of αKG-dependent dioxygenases. Signals that […]

Clinical Cancer Research: EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma

March 1, 2020

Shaofang Wu 1, Feng Gao 1, Siyuan Zheng 2, Chen Zhang 1, Emmanuel Martinez-Ledesma 1 3, Ravesanker Ezhilarasan 4, Jie Ding 1, Xiaolong Li 1, Ningping Feng 5, Asha Multani 6, Erik P Sulman 4, Roel G Verhaak 2, John F de Groot 1, Tim P Heffernan 5, W K Alfred Yung 1, Dimpy Koul 7 Abstract Purpose: Exploration of novel strategies to extend the benefit of PARP inhibitors beyond BRCA-mutant cancers is of great interest in personalized medicine. Here, we identified EGFR amplification as a potential biomarker to predict sensitivity […]

Springer: Prospective use of the single-mouse experimental design for the evaluation of PLX038A

January 11, 2020

Samson Ghilu, Qilin Li, Shaun D. Fontaine, Daniel V. Santi, Raushan T. Kurmasheva, Siyuan Zheng & Peter J. Houghton Abstract Purpose Defining robust criteria for drug activity in preclinical studies allows for fewer animals per treatment group, and potentially allows for the inclusion of additional cancer models that more accurately represent genetic diversity and, potentially, allows for tumor sensitivity biomarker identification. Methods […]

Cell Reports: Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

November 5, 2019

Author links open overlay panelJo LynneRokita123  Komal S.Rathi23  Maria F.Cardenas4  Kristen A.Upton1  JoyJayaseelan4  Katherine L.Cross5  JacobPfeil6  Laura E.Egolf17  Gregory P.Way8  AlvinFarrel2  Nathan M.Kendsersky19  KhushbuPatel2  Krutika S.Gaonkar23  ApexaModi18  Esther R.Berko1  GonzaloLopez12  ZalmanVaksman2  ChelseaMayoh10  JonasNance11  KristynMcCoy11  MichelleHaber10  KathrynEvans10  HannahMcCalmont10  KaterinaBendak10  Julia W.Böhm10  Glenn M.Marshall1012  VanessaTyrrell13  KarthikKalletla23  Frank K.Braun14  LinQi1516  YunchenDu1516  HuiyuanZhang1516Holly B.Lindsay1516  SiboZhao1516JackShu1516  PatriciaBaxter1516  ChristopherMorton17  DiasKurmashev18  SiyuanZheng18 […]

Neuro-Oncology Advances: PELP1 promotes glioblastoma progression by enhancing Wnt/β-catenin signaling

November 5, 2019

Gangadhara R Sareddy 1 2, Uday P Pratap 1, Suryavathi Viswanadhapalli 1, Prabhakar Pitta Venkata 1, Binoj C Nair 1, Samaya Rajeshwari Krishnan 1, Siyuan Zheng 3 2, Andrea R Gilbert 4, Andrew J Brenner 5 2, Darrell W Brann 6, Ratna K Vadlamudi 1 2 Abstract Background: Glioblastoma (GBM) is a deadly neoplasm of the central nervous system. The molecular mechanisms and players that contribute to GBM development are incompletely understood. Methods: The expression of PELP1 in different grades of glioma […]

Cancer Research: Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma

October 1, 2019

Xiaolong Li 1, Emmanuel Martinez-Ledesma 1 2, Chen Zhang 1, Feng Gao 1, Siyuan Zheng 1, Jie Ding 1, Shaofang Wu 1, Nghi Nguyen 3, Stephan C Clifford 3, Patrick Y Wen 4, Keith L Ligon 4, W K Alfred Yung 1, Dimpy Koul 5 Abstract PI3K-targeting therapy represents one of the most sought-after therapies for glioblastoma (GBM). Several small-molecule inhibitors have been evaluated in clinical trials, however, the emergence of resistance limits treatment potential. Here, we generated a patient-derived glioma […]

The Journal of Clinical Endocrinology & Metabolism: Synonymous but Not Silent: A Synonymous VHL Variant in Exon 2 Confers Susceptibility to Familial Pheochromocytoma and von Hippel-Lindau Disease

September 1, 2019

Shahida K Flores, Ziming Cheng, Angela M Jasper, Keiko Natori, Takahiro Okamoto, Akiyo Tanabe, Koro Gotoh, Hirotaka Shibata, Akihiro Sakurai, Takuya Nakai, Xiaojing Wang, Magnus Zethoven, Shiva Balachander, Yuichi Aita, William Young, Jr., Siyuan Zheng, Kazuhiro Takekoshi, Eijiro Nakamura, Richard W Tothill, Ricardo C T Aguiar, Patricia L M Dahia Abstract Context von Hippel-Lindau (VHL) disease, comprising renal cancer, hemangioblastoma, and/or pheochromocytoma (PHEO), is caused by missense or truncating variants of the VHL tumor-suppressor gene, which […]

Dr Siyuan Zheng discusses how the Greehey Institute is continuing to advance the care of children affected by cancer through innovative and translational research. (Gupta Mention)

June 18, 2019

The past decade has witnessed a revolution in cancer research, largely driven by advances in high-throughput sequencing, functional genomics, and computational technologies. The affordability and technological maturity of high-throughput data generation enable individual labs to test and validate their hypotheses using unbiased approaches and facilitate consortium efforts such as The Cancer Genome Atlas (TCGA), Therapeutically […]

Innovation News Network: Innovative genomics and bioinformatics research at the Greehey Institute (Multiple Investigators)

June 18, 2019

The past decade has witnessed a revolution in cancer research, largely driven by advances in high-throughput sequencing, functional genomics, and computational technologies. The affordability and technological maturity of high-throughput data generation enable individual labs to test and validate their hypotheses using unbiased approaches and facilitate consortium efforts such as The Cancer Genome Atlas (TCGA), Therapeutically […]

Molecular Cancer Therapeutics: Prospective Clinical Sequencing of Adult Glioma

May 1, 2019

Siyuan Zheng, Kristin Alfaro-Munoz, Wei Wei, Xiaojing Wang, Fang Wang, Agda Karina Eterovic, Kenna R Mills Shaw, Funda Meric-Bernstam, Gregory N Fuller, Ken Chen, Roel G Verhaak, Gordon B Mills, WK Alfred Yung, Shiao-Pei Weathers, John F de Groot Malignant gliomas are a group of intracranial cancers associated with disproportionately high mortality and morbidity. Here, […]