Libich Lab
David S. Libich, Ph.D.
St. Baldrick’s Foundation Scholar
Rank: Assistant Professor
Department: Biochemistry & Structural Biology
Office: Greehey CCRI: 4.100.22 / RAB: 5.206.2
Tel: 210-562-9064 | 210-450-8326
Email: libich@uthscsa.edu
UTHSA Faculty Profile: David Libich,, Ph.D.
Lab Research
Protein interactions mediate all cellular functions, activities, and communications. Despite their crucial importance, we know relatively little about many of these interactions due in large part to experimental limitations of structural biology. The central theme of my lab revolves around the determination of the structure and elucidation of the molecular mechanisms of highly dynamic and transient protein interactions. Our current efforts are focused on understanding the assembly and functional interactions of the low-complexity domains of RNA-binding proteins involved in cancer and neurodegenerative processes. In particular, we are interested in the oncogenic fusion protein EWS-Fli1 and the structural implications of its role as the sole driver of Ewing’s sarcoma. These types of proteins are challenging targets for biophysical characterization due to their extreme structural heterogeneity and propensity to aggregate.
Lab Staff
Jamie Alejandro Garcia
Graduate Research Assistant
Courtney Johnson
Graduate Research Assistant
Alma Moreno Romero
Research Assistant
George Parra
Graduate Research Assistant
Greehey Graduate Fellowship
Xiaoping Xu
Research Scientist
- PIPETTE GAZETTE: George Parra (Libich Lab) Receives the Greehey Graduate Fellowship in Children’s Health September 3, 2020
- St. Baldrick’s Foundation awards $306,000 for Ewing sarcoma studies August 20, 2019
- UT Health SA Newsroom: Greehey Institute begins 2018 with new faculty studying children’s cancer January 18, 2018