Libich Lab

Lab Research

Protein interactions mediate all cellular functions, activities, and communications. Despite their crucial importance, we know relatively little about many of these interactions due in large part to experimental limitations of structural biology. The central theme of my lab revolves around the determination of the structure and elucidation of the molecular mechanisms of highly dynamic and transient protein interactions. Our current efforts are focused on understanding the assembly and functional interactions of the low-complexity domains of RNA-binding proteins involved in cancer and neurodegenerative processes. In particular, we are interested in the oncogenic fusion protein EWS-Fli1 and the structural implications of its role as the sole driver of Ewing’s sarcoma. These types of proteins are challenging targets for biophysical characterization due to their extreme structural heterogeneity and propensity to aggregate.

Lab Staff

Antoine Baudin, PhD
Postdoctoral Fellow

Benita D’Souza
Visiting Scientist

Jamie Alejandro Garcia
Graduate Research Assistant

Courtney Johnson
Graduate Research Assistant

Alma Moreno Romero
Research Assistant

George Parra
Graduate Research Assistant
Greehey Graduate Fellowship

Lois Randolph
Student

Emily Selig, PhD
Postdoctoral Fellow

Xiaoping Xu
Research Scientist

Donald G McEwen, Memorial Summer Undergraduate Research Program student

• Hoang Dinh

News

• JoVE: Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins (Libich Lab) October 13, 2021
• Frontiers in Molecular BioScience: Structural Characterization of the RNA-Binding Protein SERBP1 Reveals Intrinsic Disorder and Atypical RNA Binding Modes (Libich & Penalva labs) October 13, 2021
• Biomolecular NMR Assignments: The 1H, 15N and 13C resonance assignments of the C‑terminal domain of Serpine mRNA binding protein 1 (SERBP1), (Libich Lab) August 30, 2021

All news