Libich Lab
David S. Libich, PhD
St. Baldrick’s Foundation Scholar
Rank: Assistant Professor
Department: Biochemistry & Structural Biology
Office: Greehey CCRI: 4.100.22 / RAB: 5.206.2
Tel: 210-562-9064 | 210-450-8326
Email:
UTHSA Faculty Profile: David Libich,, PhD
Lab Research
Protein interactions mediate all cellular functions, activities, and communications. Despite their crucial importance, we know relatively little about many of these interactions due in large part to experimental limitations of structural biology. The central theme of my lab revolves around the determination of the structure and elucidation of the molecular mechanisms of highly dynamic and transient protein interactions. Our current efforts are focused on understanding the assembly and functional interactions of the low-complexity domains of RNA-binding proteins involved in cancer and neurodegenerative processes. In particular, we are interested in the oncogenic fusion protein EWS-Fli1 and the structural implications of its role as the sole driver of Ewing’s sarcoma. These types of proteins are challenging targets for biophysical characterization due to their extreme structural heterogeneity and propensity to aggregate.
Lab Staff
Antoine Baudin, PhD
Postdoctoral Fellow
Benita D’Souza
Visiting Scientist
Jamie Alejandro Garcia
Graduate Research Assistant
Courtney Johnson
Graduate Research Assistant
Alma Moreno Romero
Research Assistant
George Parra
Graduate Research Assistant
Greehey Graduate Fellowship
Lois Randolph
Student
Emily Selig, PhD
Postdoctoral Fellow
Xiaoping Xu
Research Scientist
- Emily Selig of Libich Lab, Awarded a Spot on CPRIT Training Grant January 8, 2021
- PIPETTE GAZETTE: George Parra (Libich Lab) Receives the Greehey Graduate Fellowship in Children’s Health September 3, 2020
- KENS5: UT Health gets a $306,000 grant to study Ewing sarcoma September 16, 2019