Libich Lab

Libich Lab Members

David S. Libich, PhD

St. Baldrick’s Foundation Scholar

Rank: Assistant Professor
Department: Biochemistry & Structural Biology
Office: Greehey CCRI: 4.100.22 / RAB: 5.206.2
Tel: 210-562-9151  |  210-450-8326
libich@uthscsa.edu

UTHSA Faculty Profile: David Libich,, PhD

Publications

Lab Research

Protein interactions mediate all cellular functions, activities, and communications. Despite their crucial importance, we know relatively little about many of these interactions due in large part to experimental limitations of structural biology. The central theme of my lab revolves around the determination of the structure and elucidation of the molecular mechanisms of highly dynamic and transient protein interactions. Our current efforts are focused on understanding the assembly and functional interactions of the low-complexity domains of RNA-binding proteins involved in cancer and neurodegenerative processes. In particular, we are interested in the oncogenic fusion protein EWS-Fli1 and the structural implications of its role as the sole driver of Ewing’s sarcoma. These types of proteins are challenging targets for biophysical characterization due to their extreme structural heterogeneity and propensity to aggregate.

Lab Staff

Victoria Alers (co-advised with Dr. Penalva)
Student

Antoine Baudin, PhD
Postdoctoral Fellow

Hoang Dinh
Research Assistant

Courtney Johnson
Graduate Research Assistant

Emily Lancaster, PhD.
Postdoctoral Fellow

George Parra
Graduate Research Assistant
Greehey Graduate Fellowship
TL1 translational science fellowship

Emily Selig, PhD
Postdoctoral Fellow

Erich Sohn
Graduate Student

Xiaoping Xu
Research Scientist

Featured News

JoVE: Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins (Libich Lab)

Emily Selig of Libich Lab, Awarded a Spot on CPRIT Training Grant

KENS5: UT Health gets a $306,000 grant to study Ewing sarcoma

All news