Libich Lab
David S. Libich, PhD
St. Baldrick’s Foundation Scholar
Rank: Assistant Professor
Department: Biochemistry & Structural Biology
Office: Greehey CCRI: 4.100.22 / RAB: 5.206.2
Tel: 210-562-9151 | 210-450-8326
libich@uthscsa.edu
Lab Research
Protein interactions mediate all cellular functions, activities, and communications. Despite their crucial importance, we know relatively little about many of these interactions due in large part to experimental limitations of structural biology. The central theme of my lab revolves around the determination of the structure and elucidation of the molecular mechanisms of highly dynamic and transient protein interactions. Our current efforts are focused on understanding the assembly and functional interactions of the low-complexity domains of RNA-binding proteins involved in cancer and neurodegenerative processes. In particular, we are interested in the oncogenic fusion protein EWS-Fli1 and the structural implications of its role as the sole driver of Ewing’s sarcoma. These types of proteins are challenging targets for biophysical characterization due to their extreme structural heterogeneity and propensity to aggregate.
Lab Staff
Victoria Alers (co-advised with Dr. Penalva)
Student
Antoine Baudin, PhD
Postdoctoral Fellow
Hoang Dinh
Research Assistant
Courtney Johnson
Graduate Research Assistant
Emily Lancaster, PhD.
Postdoctoral Fellow
George Parra
Graduate Research Assistant
Greehey Graduate Fellowship
TL1 translational science fellowship
Emily Selig, PhD
Postdoctoral Fellow
Erich Sohn
Graduate Student
Xiaoping Xu
Research Scientist
Featured News
Emily Selig of Libich Lab, Awarded a Spot on CPRIT Training Grant
KENS5: UT Health gets a $306,000 grant to study Ewing sarcoma
- The Gear Up Against Kids Cancer Rides Again! January 20, 2023
- SAVE-THE-DATE: San Antonio Pediatric Cancer Symposium (SAPCS) May 10, 2022
- Biomolecular NMR Assignments: The 1H, 15N and 13C resonance assignments of the low-complexity domain from the oncogenic fusion protein EWS-FLI1 (Libich Lab) January 12, 2022