Libich Lab
David S. Libich, PhD
St. Baldrick’s Foundation Scholar
Rank: Associate Professor
Department: Biochemistry & Structural Biology
Office: Greehey CCRI: 4.100.22 / RAB: 5.206.2
Tel: 210-562-9151 | 210-450-8326
libich@uthscsa.edu
St. Baldrick’s Foundation Scholar
Rank: Associate Professor
Department: Biochemistry & Structural Biology
Office: Greehey CCRI: 4.100.22 / RAB: 5.206.2
Tel: 210-562-9151 | 210-450-8326
libich@uthscsa.edu
Protein interactions mediate all cellular functions, activities, and communications. Despite their crucial importance, we know relatively little about many of these interactions due in large part to experimental limitations of structural biology. The central theme of my lab revolves around the determination of the structure and elucidation of the molecular mechanisms of highly dynamic and transient protein interactions. Our current efforts are focused on understanding the assembly and functional interactions of the low-complexity domains of RNA-binding proteins involved in cancer and neurodegenerative processes. In particular, we are interested in the oncogenic fusion protein EWS-Fli1 and the structural implications of its role as the sole driver of Ewing’s sarcoma. These types of proteins are challenging targets for biophysical characterization due to their extreme structural heterogeneity and propensity to aggregate.
Victoria Alers (co-advised with Dr. Penalva)
Student
Antoine Baudin, PhD
Postdoctoral Fellow
Hoang Dinh
Research Assistant
Emily Lancaster, PhD.
Postdoctoral Fellow
George Parra
Graduate Research Assistant
Greehey Graduate Fellowship
TL1 translational science fellowship
Erich Sohn
Graduate Student
Xiaoping Xu
Research Scientist
KENS5: UT Health gets a $306,000 grant to study Ewing sarcoma
UT Health SA Newsroom: Greehey cancer researcher receives UT System’s Rising STARs award
Science: CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade (Sung & Libich Labs)
May 23, 2025