Luiz O.F. Penalva, PhD
Department: Cell Systems & Anatomy
Major components of my research program include:
- Screening and characterization of RBPs and miRNAs implicated in neuronal stem cell function and brain tumors.
- Construction of regulatory maps for neuronal differentiation and brain tumor development.
- Development and improvement of computational and functional methods for miRNA/RBP target identification and functional outcome.
- Development of RNA based approaches for therapy.
Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles.
Guardia GDA, Correa BR, Araujo PR, Qiao M, Burns S, Penalva LOF*, Galante PAF*.
NPJ Genom Med. 2020 Jan 16;5:2. doi: 10.1038/s41525-019-0108-5. eCollection 2020.
PMID:31969990 * co-corresponding authors
Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis.
Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN.
Cell Stem Cell. 2019 Dec 31. pii: S1934-5909(19)30471-0. doi: 10.1016/j.stem.2019.11.016.
ELF4 Is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated State.
Kosti A, Du L, Shivram H, Qiao M, Burns S, Garcia JG, Pertsemlidis A, Iyer VR, Kokovay E, Penalva LOF.
Mol Cancer Res. 2020 Jan;18(1):68-78. doi: 10.1158/1541-7786.MCR-19-0187.
The Diverse Roles of RNA-Binding Proteins in Glioma Development.
Velasco MX, Kosti A, Penalva LOF*, Hernández G*.
Adv Exp Med Biol. 2019;1157:29-39. doi: 10.1007/978-3-030-19966-1_2.
PMID: 31342436 * co-corresponding authors
Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development.
Velasco MX, Kosti A, Guardia GDA, Santos MC, Tegge A, Qiao M, Corre BRS, Hernández G, Kokovay E, Galante PAF, Penalva LOF.
RNA. 2019 Jul;25(7):768-782. doi: 10.1261/rna.069211.118.
RNA biology, genomics, RNA binding proteins, miRNAs, alternative splicing, translation, brain tumors
RNA binding proteins (RBPs) and miRNAs play significant roles in gene expression by controlling all stages of mRNA processing, its transport, localization, decay, and translation. My laboratory studies these two regulators from a global perspective. We use a combination of genomics, systems biology, biochemistry, bioinformatics, and molecular biology to investigate the networks formed by RNA binding proteins, miRNAs and their target genes and evaluate their impact on biological processes, cancer, and disease states. I am particularly interested in the neuronal tissue and the analysis of gene regulators implicated in both differentiation and brain tumor development.
- Musashi1 in brain tumor development
- miRNAs in neurogenesis and brain tumor development
- Alternative splicing and translation regulation
- Understanding the dynamics of translation regulation
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Graduate Research Assistant
Yiqiang Zhang, PhD
- APPLICATIONS NOW BEING ACCEPTED: Greehey CCRI Donald G McEwen, Memorial Summer 2021 Undergraduate Research Program April 6, 2021
- Cancer Research: Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy (Penalva Lab) March 30, 2021
- Development: The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway (Penalva Lab) March 30, 2021