Nature Communications: Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL (Sung)
April 2, 2024Digant Nayak, Dongwen Lv, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Anindita Nayak, Eliza A. Ruben, Zongyang Lv, Patrick Sung, Robert Hromas, Guangrong Zheng, Daohong Zhou & Shaun K. Olsen Abstract Overexpression of BCL-xL and BCL-2 play key roles in tumo …
Frontiers in Cell and Developmental Biology: Editorial: RNA-binding proteins in cancer: advances in translational research (Penalva)
March 27, 2024Caterina Mancarella1* Nadine Bley2 Luiz O. F. Penalva3,4 RNA-binding proteins (RBPs) regulate RNA metabolism, processing, and translation by establishing highly dynamic interactions with hundreds of coding and non-coding target RNAs within ribonucleopr …
San Antonio Report: UT Health San Antonio President William Henrich has died
March 14, 2024Breaking News San Antonio Report: UT Health San Antonio President William Henrich has died (Back row, Middle) Dr. Henrich Originally posted, San Antonio Report 3/14/24 Dr. William L. Henrich, the president of UT Health San Antonio, has died, the school …
Greehey CCRI part of “CPRIT funding of $16.4 million over six months adds transformative expertise, bolsters cancer research.”
March 8, 2024Posted initially on UT Health San Antonio Newsroom on March 7, 2024 at 6:44 am. Shared by Steven Lee Contact: Steven Lee, 210-450-3823, lees22@uthscsa.edu Content contributed by Juanita Alvarez-Hernandez SAN ANTONIO, March 7, 2024 – The University of T …
Patterns: shinyDeepDR: A user-friendly R Shiny app for predicting anti-cancer drug response using deep learning (Chen lab, et al)
February 20, 2024Li-Ju Wang 1, Michael Ning 1, Tapsya Nayak 2, Michael J. Kasper 1, Satdarshan P. Monga 3 4 5, Yufei Huang 5 6 7 8, Yidong Chen 2 9, Yu-Chiao Chiu 1 4 5 10 Show more Highlights shinyDeepDR is a web tool for predicting responses to 265 anti-cancer compou …
iScience: RNA helicase DDX3 regulates RAD51 localization and DNA damage repair in Ewing sarcoma (Bishop)
February 15, 2024Matthew E. Randolph 1 2, Marwa Afifi 3, Aparna Gorthi 4, Rachel Weil 1, Breelyn A. Wilky 5, Joshua Weinreb 1, Paul Ciero 1 2, Natalie ter Hoeve 7, Paul J. van Diest 7, Venu Raman 5 6 8, Alexander J.R. Bishop 4, David M. Loeb 1 2 5 9 Highlights •Impaire …
Genes & Cancer: Roles of USP1 in Ewing sarcoma (Shiio Lab)
February 13, 2024Panneerselvam Jayabal1, Xiuye Ma1 and Yuzuru Shiio1,2,3 ABSTRACT Ewing sarcoma is a cancer of bone and soft tissue in children and young adults that is driven by the EWS-ETS fusion transcription factor, most commonly EWS-FLI1. We previously reported th …
Nature Communications: Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset (Chen, Zheng)
February 8, 2024Yi Xu, Michael H. Nipper, Angel A. Dominguez, Zhenqing Ye, Naoki Akanuma, Kevin Lopez, Janice J. Deng, Destiny Arenas, Ava Sanchez, Francis E. Sharkey, Colin M. Court, Aatur D. Singhi, Huamin Wang, Martin E. Fernandez-Zapico, Lu-Zhe Sun, Siyuan Zheng, …
Cancers: The Versatile Attributes of MGMT: Its Repair Mechanism, Crosstalk with Other DNA Repair Pathways, and Its Role in Cancer (Sung Lab)
February 5, 2024by Qingming Fang Simple Summary This review offers a thorough examination of the potential role and structural properties of MGMT, the progression in targeting MGMT, and the interactions between MGMT and DNA repair pathways involved in processing DNA …
Genetic Counseling: Families’ experiences accessing care after genomic sequencing in the pediatric cancer context: “It’s just been a big juggle” (Tomlinson)
January 18, 2024Blake Vuocolo, Amanda M. Gutierrez, Jill O. Robinson, Alva M. Recinos, Lauren R. Desrosiers, Mary A. Majumder, Juan Carlos Bernini, Jonathan Gill, Timothy Griffin, Gail E. Tomlinson, Kelly Vallance, Amy L. McGuire, D. Williams Parsons, Sharon E. Plon, …