Kids Cancer CEO (Community Engagement & Outreach) : Differences between adult and pediatric cancers – Molecular Oncology Series
December 4, 2023Molecular Oncology Series Patient response to cancer malignancies differs significantly from one patient to the next. These differences can be attributed to the patient’s case-by-case scenario in terms of co-morbidities, location of the tumor, and what …
Molecular and Cellular Biology: A SNAI2/CTCF Interaction is Required for NOTCH1 Expression in Rhabdomyosarcoma (Ignatius Lab)
December 1, 2023Prethish Sreenivas,Long Wang,Meng Wang,Anil Challa,Paulomi Modi,Nicole Rae Hensch,Berkley Gryder,Hsien-Chao Chou,Xiang R. Zhao,Benjamin Sunkel,Rodrigo Moreno-Campos,Javed Khan,Benjamin Z. Stanton & Myron S. Ignatius Abstract Rhabdomyosarcoma (RMS) …
Nucleic Acids Research: TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells (Sung, Gupta, Pertsemlidis, Bishop, et al)
November 29, 2023Aruna S Jaiswal, Arijit Dutta, Gayathri Srinivasan, Yaxia Yuan, Daohong Zhou, Montaser Shaheen, Doraid T Sadideen, Austin Kirby, Elizabeth A Williamson, Yogesh K Gupta, Shaun K Olsen, Mingjiang Xu, Eva Loranc, Pramiti Mukhopadhyay, Alexander Pertsemlid …
OpenAccessGovernment.org: Current and future therapy for BRAF-mutant pediatric glioma
November 20, 2023Professor Peter J. Houghton from the Greehey Children’s Cancer Research Institute discusses new approaches to pediatric cancer treatment, specifically for BRAF-mutant pediatric glioma. Low-grade glioma (LGG) is the most frequently diagnosed brain tumor …
Nucleic Acids Research: TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells (Gupta, Pertsemlidis, Bishop, & Sung Labs)
November 20, 2023Aruna S Jaiswal, Arijit Dutta, Gayathri Srinivasan, Yaxia Yuan, Daohong Zhou, Montaser Shaheen, Doraid T Sadideen, Austin Kirby, Elizabeth A Williamson, Yogesh K Gupta, Shaun K Olsen, Mingjiang Xu, Eva Loranc, Pramiti Mukhopadhyay, Alexander Pertsemlid …
Molecular Cell: DICER Ribonuclease Removes Harmful R-Loops (Sung)
October 18, 2023Lola P. Camino 1 2 4, Arijit Dutta 3 4, Sonia Barroso 1 2, Carmen Pérez-Calero 1 2, Jeffrey N. Katz 3, María García-Rubio 1 2, Patrick Sung 3, Belén Gómez-González 1 2, Andrés Aguilera 1 2 5 Highlights •DICER RNase activity mediates R-loop processing i …
Open Access Government: Developing novel therapies for childhood cancers (Houghton)
September 19, 2023Dr Peter J Houghton from Greehey Children’s Cancer Research Institute discusses the obstacles in developing new treatments for childhood cancers and new approaches in preclinical testing. In my previous article for Open Access Government, I focused on …
Cancers: Dysregulation of Type I Interferon (IFN-I) Signaling: A Potential Contributor to Racial Disparity in Hepatocellular Carcinoma (HCC) (Lai)
September 12, 2023Saranya Chidambaranathan Reghupaty 1,†,Sadia Kanwal 2, Rachel G. Mendoza 3, Eva Davis 4,Haiwen Li 2, Zhao Lai 5, Mikhail G. Dozmorov 6 ,Milton Omar Faison 7, Rafat Ali Siddiqui 2, *Devanand Sarkar 8,* Simple Su …
Texas Public Radio: “Fighting childhood cancer in San Antonio” (Aune)
September 8, 2023September is Childhood Cancer Awareness Month, a time to raise awareness of this devastating disease and to support the children and families who are affected by it. Childhood cancer is the leading cause of death by disease for children under the age o …
Embro Reports: Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping (Chen)
September 5, 2023Abstract Bromodomain-containing protein 4 (BRD4) is overexpressed and functionally implicated in various myeloid malignancies. However, the role of BRD4 in normal hematopoiesis remains largely unknown. Here, utilizing an inducible Brd4 knockout mouse m …