Bioorganic & Medicinal Chemistry: Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types
June 1, 2019JorgeDe La Chapaa, Matthew Valdezb, Franscisco RuizIIIb, Keith Gonzalesb, Wes Mitchellb, Stanton F.McHardybc, Matthew Hartbc, Srikanth R.Polusanib, Cara B.Gonzalesac Abstract We previously demonstrated that capsazepine (CPZ), a synthetic transient rece …
YouTube: UT Health SA, “Why We Do What We Do” – Greg Aune, M.D.
May 29, 2019https://www.youtube.com/watch?v=pQ-0d35yw7c “Greg Aune, M.D. addresses attendees of the 2019 Annual (UT Health- San Antonio) President’s Luncheon “Why We Do What We Do”. Aune Lab
Journal of Translational Immunology: IL‐1 receptor antagonist, anakinra, prevents myocardial dysfunction in a mouse model of Kawasaki disease vasculitis and myocarditis
May 17, 2019M. Gorelik Y. Lee M. Abe T. Andrews L. Davis J. Patterson S. Chen T. R. Crother G. J. Aune M. Noval Rivas M. Arditi Summary Kawasaki disease (KD) vasculitis is an acute febrile illness of childhood characterized by systemic vasculitis of unknown ori …
Journal of Immunology: Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer
May 15, 2019Merit L Goodman 1 2 3, Gloria M Trinca 1 2 3, Katherine R Walter 1 2 3, Evangelia K Papachristou 4, Clive S D’Santos 4, Tianbao Li 5, Qi Liu 5, Zhao Lai 5 6, Prabhakar Chalise 7, Rashna Madan 8, Fang Fan 8, Mary A Markiewicz 9, Victor X Jin 5, Jason S …
Cell: Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities
May 2, 2019Author links open overlay panelSuhasVasaikar1214ChenHuang1214XiaojingWang121214Vladislav A.Petyuk314Sara R.Savage414BoWen12YongchaoDou12YunZhang1ZhiaoShi12Osama A.Arshad3Marina A.Gritsenko3Lisa J.Zimmerman5Jason E.McDermott3Therese R.Clauss3Ronald J.Mo …
Molecular Cancer Therapeutics: Prospective Clinical Sequencing of Adult Glioma
May 1, 2019Siyuan Zheng, Kristin Alfaro-Munoz, Wei Wei, Xiaojing Wang, Fang Wang, Agda Karina Eterovic, Kenna R Mills Shaw, Funda Meric-Bernstam, Gregory N Fuller, Ken Chen, Roel G Verhaak, Gordon B Mills, WK Alfred Yung, Shiao-Pei Weathers, John F de Groot Malig …
Molecular Cancer Therapeutics: Prospective Clinical Sequencing of Adult Glioma
May 1, 2019Siyuan Zheng 1 2 3, Kristin Alfaro-Munoz 4, Wei Wei 5, Xiaojing Wang 3, Fang Wang 6, Agda Karina Eterovic 7, Kenna R Mills Shaw 7, Funda Meric-Bernstam 7, Gregory N Fuller 8, Ken Chen 6, Roel G Verhaak 4 2 6 9, Gordon B Mills 7, W K Alfred Yung 4, Shia …
Clinical Cancer Research: Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models
April 25, 2019Caitlin D Lowery 1, Michele Dowless 1, Matthew Renschler 1, Wayne Blosser 1, Alle B VanWye 1, Jennifer R Stephens 1, Philip W Iversen 1, Aimee Bence Lin 1, Richard P Beckmann 1, Kateryna Krytska 2, Kristina A Cole 2, John M Maris 2, Douglas S Hawkins 3 …
Pediatric Blood & Cancer: Preclinical activity of the antibody‐drug conjugate denintuzumab mafodotin (SGN‐CD19A) against pediatric acute lymphoblastic leukemia xenografts
April 23, 2019Luke Jones, Hannah McCalmont, Kathryn Evans, Chelsea Mayoh, Raushan T. Kurmasheva, Catherine A. Billups, Peter J. Houghton, Malcolm A. Smith, Richard B. Lock Abstract Background Denintuzumab mafodotin (SGN‐CD19A) is a CD19‐targeting antibody‐drug conj …
Nature: More and more people are living for years after treatment. Researchers should look for ways to identify and ease long-term effects.
April 19, 2019When Gregory Aune was 16, he wasn’t particularly concerned about the lasting effects of the drugs and radiation that he was given to treat his lymphoma. “I saw kids around me die, so I felt pretty fortunate,” he says. Nearly 30 years later, Aune has a …