Greehey CCRI Archives
Scientific Reports: A comprehensive meta-analysis and a case–control study give insights into genetic susceptibility of lung cancer and subgroups (Bishop Lab)
July 19, 2021Debmalya Sengupta, Souradeep Banerjee, Pramiti Mukhopadhyay (Bishop Lab) Ritabrata Mitra, Tamohan Chaudhuri, Abhijit Sarkar, Gautam Bhattacharjee, Somsubhra Nath, Susanta Roychoudhury, Samsiddhi Bhattacharjee & Mainak Sengupta Abstract Reports of …
eLife Sciences: Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness (Shiio Lab)
July 9, 2021Haritha Mathsyaraja, Jonathen Catchpole, Brian Freie, Emily Eastwood, Ekaterina Babaeva, Michael Geuenich, Pei Feng Cheng, Jessica Ayers, Ming Yu, Nan Wu, Sitapriya Moorthi, Kumud R Poudel, Amanda Koehne, William Grady, A Mc …
Cell Reports: NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growthNELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth (Shiio, Houghton)
July 8, 2021Panneerselvam Jayabal1, Fuchun Zhou1, Xiufen Lei1, XiuyeMa1, Barron Blackman1, Susan T.Weintraub23, Peter J.Houghton134, YuzuruShiio1235 Highlights • The autocrine signaling mediated by NELL2 maintains Ewing sarcoma cell growth • NELL2 signaling inhibi …
Dr. Houghton Co-Authors MDPI paper, “Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells
July 2, 2021Authored by: Jun Luo, Yoshinobu Odaka, Zhu Huang, Bing Cheng, Wang Liu, Lin Li, Chaowei Shang, Chao Zhang, Yang Wu, Yan Luo, Shengyong Yang, Peter J. Houghton, Xiaofeng Guo, Shile Huang Abstract Dihydroartemisinin (DHA), an anti-malarial drug, has been …
Nature Communications: Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase (Gupta)
June 29, 2021Yogesh Gupta PhD Olga Rechkoblit, Robert E. Johnson, Yogesh K. Gupta, Louise Prakash, Satya Prakash & Aneel K. Aggarwal Abstract PrimPol is a human DNA polymerase-primase that localizes to mitochondria and nucleus and bypasses the major oxidative l …
Pertsemlidis Lab Awarded American Lung Association Grant to Study “Identifying Exploitable Biomarkers of Lung Cancer Metastasis”
June 16, 2021Greehey CCRI Principal Investigator, Alexander Pertsemlidis, PhD Abstract Rationale. Most cancer deaths are caused by metastatic disease, and the prevention of metastasis is a significant focus of clinical research. Aberrant expression of miRNAs has be …
St. Baldrick’s: Checking the Life-Threatening Box: A Survivor’s Update (Aune)
June 16, 2021A childhood cancer survivor himself, Gregory J. Aune, MD, PhD, shares his personal experience and thoughts during National Cancer Survivor Month. (Originally posted on Medium on May 19th, Dr. Aune graciously agreed to …
Greehey CCRI’s Genomic Sequencing Facility to Receive $600,000 NIH Grant to upgrade genomic sequencing capabilities (Lai Lab).
June 15, 2021Dr. Zhao Lai, Director of the Genomic Sequencing Facility (GSF) at the Greehey Children’s Cancer Research Institute (Greehey CCRI) at UT Health San Antonio (UTHSA), has been awarded a $600,000 NIH grant to help purchase a new Illumina NovaSeq 6000. Thi …
Aging Cell: Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury (Chen Lab)
June 12, 2021Hak Joo Lee, Andrew Donati, Denis Feliers, Yuyang Sun, Yanli Ding, Muniswamy Madesh, Adam B. Salmon, Yuji Ikeno, Corinna Ross, Christopher L. O’Connor, Wenjun Ju, Markus Bitzer, Yidong Chen, Goutam Ghosh Choudhury, Brij B. Singh, Kumar Sharma, Balakunt …
Molecular Cancer Therapeutics: International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer (Houghton)
June 4, 2021Gilles Vassal, Peter J Houghton, Stefan M Pfister, Malcolm A. Smith, Huib N Caron, Xiao-Nan Li, David J Shields, Olaf Witt, Jan J Molenaar, Sara Colombetti, Julia Schuler, and Lou F Stancato Abstract Cancer remains the leading cause of disease-related …