Greehey CCRI News & Events Archive

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Journal of Oral Pathology & Medicine: The novel capsazepine analog, CIDD‐99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1‐independent induction of ER stress, mitochondrial dysfunction, and apoptosis

February 3, 2019

Jorge J. De La Chapa, Prajjal K. Singha, Kristen K. Self, McKay L. Sallaway, Stanton F. McHardy, Matthew J. Hart, Howard Stan McGuff, Matthew C. Valdez Francisco Ruiz II, Srikanth R. Polusani, Cara B. Gonzales Abstract Background Oral squamous cell car …


Oncology Learning Network: Podcast – Daunorubicin Decreases Long-Term Cardiomyopathy Risk in Cancer Survivors

January 31, 2019

In an interview with Oncology Learning Network, Gregory J. Aune, MD, Assistant Professor of Pediatrics at UT Health San Antonio and Greehey Children’s Cancer Research Institute, discussed his team’s findings from a multicenter study evaluating the long …


Drug Discovery & Development: Do All Chemotherapies Have Equal Long-Term Heart Risk?

January 31, 2019

Gregory Aune, M.D., PhD, of UT Health San Antonio, served on a team that found different chemotherapy drugs used to treat children with cancer appear to have different risks long term for cardiomyopathy (abnormal heart muscle with impaired function). T …


BMC Medical Genomics: Predicting drug response of tumors from integrated genomic profiles by deep neural networks

January 31, 2019

Yu-Chiao Chiu, Hung-I Harry Chen, Tinghe Zhang, Songyao Zhang, Aparna Gorthi, Li-Ju Wang, Yufei Huang & Yidong Chen Abstract Background The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insig …


JAMA Oncology: Derivation of Anthracycline and Anthraquinone Equivalence Ratios to Doxorubicin for Late-Onset Cardiotoxicity

January 31, 2019

Elizabeth A. M. Feijen, PhD1,2; Wendy M. Leisenring, ScD3,4; Kayla L. Stratton, MS3,4; Kirsten K. Ness, PT, PhD5; Helena J. H. van der Pal, MD, PhD2; Elvira C. van Dalen, MD, PhD1,2; Gregory T. Armstrong, MD, MSCE5; Gregory J. Aune, MD, PhD6; Daniel M. …


MDPI: CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere

January 15, 2019

Yohei Niikura 1,2,* Risa Kitagawa 1 and Katsumi Kitagawa 1,* Abstract The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centr …


PLOS Computational Biology: Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods

January 2, 2019

Song-Yao Zhang, Shao-Wu Zhang, Xiao-Nan Fan, Jia Meng, Yidong Chen, Shou-Jiang Gao, Yufei Huang Abstract N6-methyladenosine (m6A) is the most abundant methylation, existing in >25% of human mRNAs. Exciting recent discoveries indicate the close invol …


BMC Systems Biology: GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization

December 21, 2018

Hung-I Harry Chen, Yu-Chiao Chiu, Tinghe Zhang, Songyao Zhang, Yufei Huang & Yidong Chen Abstract Background Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set-based analyses improve …


BMC Systems Biology: scdNet: a computational tool for single-cell differential network analysis

December 21, 2018

Yu-Chiao Chiu, Tzu-Hung Hsiao, Li-Ju Wang, Yidong Chen & Yu-Hsuan Joni Shao Abstract Background Single-cell RNA sequencing (scRNA-Seq) is an emerging technology that has revolutionized the research of tumor heterogeneity. However, the highly sparse …


PLoS One: microRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi

December 14, 2018

Zhenze Zhao, Veronica Partridge, Michaela Sousares, Spencer D. Shelton, Cory L. Holland, Alexander Pertsemlidis, Liqin Du  Abstract microRNA-2110 (miR-2110) was previously identified as inducing neurite outgrowth in neuroblastoma cell lines BE(2)-C, su …


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