Greehey CCRI News & Events Archive
Cancer Letters: miR-195 potentiates the efficacy of microtubule-targeting agents in non-small cell lung cancer
July 28, 2018Xiaojie Yuab, Yiqiang Zhanga, Xiuye Maa, Alexander Pertsemlidisabc Abstract Microtubule-targeting agents (MTAs) are widely used for the treatment of non-small cell lung cancer (NSCLC). The response rate is only ∼25%, mainly attributable to drug resista …
Oncotarget: Increased expression of the thyroid hormone nuclear receptor TRα1 characterizes intestinal tumors with high Wnt activity
July 24, 2018Joel Uchuya-Castillo, Nicolas Aznar, Carla Frau, Pierre Martinez, Clementine Le Nevé, Laetitia Marisa, Luiz OF Penalva, Pierre Laurent-Puig, Alain Puisieux, Jean-Yves Scoazec, Jacques Samarut, Stephane Ansieau, Michelina Plateroti Our previous work dem …
Journal of Clinical Oncology: Cardiovascular Disease in Survivors of Childhood Cancer: Insights Into Epidemiology, Pathophysiology, and Prevention
July 20, 2018Saro H. Armenian, Gregory T. Armstrong, Gregory Aune, Eric J. Chow, Matthew J. Ehrhardt, Bonnie Ky, ABSTRACT Cardiovascular disease (CVD), which includes cardiomyopathy/heart failure, coronary artery disease, stroke, pericardial disease, arrhythmias, …
Cell Report: Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma
July 10, 2018Seçkin Akgül 1, Yinghua Li 2, Siyuan Zheng 3, Marcel Kool 4, Daniel M Treisman 5, Chaoyang Li 2, Yuan Wang 2, Susanne Gröbner 4, Tsuneo Ikenoue 6, Yiping Shen 7, Sandra Camelo-Piragua 8, Gerald Tomasek 9, Sebastian Stark 4, Vinay Guduguntla 9, James F …
Oncotarget: LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer
July 3, 2018Liqin Du1, Zhenze Zhao1, Milind Suraokar2, Spencer S. Shelton1, Xiuye Ma3, Tzu-Hung Hsiao4, John D. Minna5, Ignacio Wistuba2,6 and Alexander Pertsemlidis3,7 ABSTRACT LMO1 encodes a protein containing a cysteine-rich LIM domain involved in protein-prote …
Cancer Letters: Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells
July 1, 2018AlfeuZanotto-Filhoac SubapriyaRajamanickama EvaLoranca V. Pragathi Masamsettia AparnaGorthiab July CarolinaRomeroab SonalTonapiab Rosangela Mayer Gonçalvesc Robert L.Reddickd RaymondBenavidese JohnKuhnde YidongChenf Alexander J.R.Bishopab A …
The Journal of Physical Chemistry Letters: Extensive Sampling of the Cavity of the GroEL Nanomachine by Protein Substrates Probed by Paramagnetic Relaxation Enhancement
June 21, 2018Marielle A Wälti 1, David S Libich 1, G Marius Clore 1 Abstract The chaperonin GroEL is an 800 kDa nanomachine comprising two heptameric rings, each of which encloses a large cavity or folding chamber. The GroEL cycle involves ATP-dependent capping of …
Cancer Research: Differential Effects of Estrogen Receptor β Isoforms on Glioblastoma Progression
June 15, 2018Jinyou Liu # 1 2, Gangadhara R Sareddy # 1 3, Mei Zhou 1 4, Suryavathi Viswanadhapalli 1, Xiaonan Li 1, Zhao Lai 5, Rajeshwar R Tekmal 1 3, Andrew Brenner 3 6, Ratna K Vadlamudi 7 3 Abstract The estrogen receptor β (ERβ) functions as a tumor suppressor …
International Journal of Genomics: Noncoding RNAs and Base Modifications: Epigenomic Players Implicated in Neurological Disorders and Tumorigenesis
June 13, 2018Zhen Wei,1,2 Subbarayalu Panneerdoss,3,4 Santosh Timilsina,3,4 Jingting Zhu,1,5 Tabrez A. Mohammad,3 Zhi-Liang Lu,1,5 João Pedro de Magalhães,2 Yidong Chen,3,6 Rong Rong,1,5 Yufei Huang,6,7 Manjeet K. Rao,3,4 and Jia Meng1,5 Abstract Background. Compar …