Greehey CCRI News & Events Archive

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Nature Genetics: Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

April 23, 2018

Ana C deCarvalho 1, Hoon Kim 2, Laila M Poisson 3, Mary E Winn 4, Claudius Mueller 5, David Cherba 4, Julie Koeman 6, Sahil Seth 7, Alexei Protopopov 7, Michelle Felicella 8, Siyuan Zheng 9, Asha Multani 10, Yongying Jiang 7, Jianhua Zhang 7, Do-Hyun N …


International Journal of Mass Spectrometry: Comprehensive and sensitive proteogenomics data analysis strategy based on complementary multi-stage database search

April 1, 2018

Inamul Hasan Madar, Wonyeop Lee, Xiaojing Wang, Seung-Ik Ko, Hokeun Kim, Dong-Gi Mun, Bing Zhang, Eunok Paek, Sang-Won Lee Proteogenomics provides opportunities for proteomic validation of gene structures, genomic alterations, and functional relevance …


Journal of Pediatric Hematology/Oncology: Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity

April 1, 2018

Wang, Fei PhD*; Iskra, Brian BS†; Kleinerman, Eugenie MD*; Alvarez-Florez, Claudia PhD*; Andrews, Thomas MSc†; Shaw, Angela MD*; Chandra, Joya PhD*; Schadler, Keri PhD*; Aune, Gregory J. MD, PhD†,‡ Abstract We report the cardioprotective effects of mod …


Technology Networks: Link Discovered Between BRCA1 Protein and Aggressive Pediatric Cancer

March 8, 2018

Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the …


Nature: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

March 7, 2018

Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A. Lawrence, Elicia Goodale, Amanda Balboni Iniguez, Xavier Bernard, V. Pragathi Masamsetti, Sydney Roston, Elizabeth R. Lawlor, Jeffrey A. Toretsky, Kimberly Stegmaier, Stephen L. Lessnic …


Scientific Reports: Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity

March 6, 2018

Bruna RS Correa, Joanna Hu, Luiz OF Penalva, Richard Schlegel, David L Rimm, Pedro AF Galante, Seema Agarwal Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug tar …


Molecular & Cellular Proteomics: Detection of proteome diversity resulted from alternative splicing is limited by trypsin cleavage specificity

March 1, 2018

Xiaojing Wang, Simona G Codreanu, Bo Wen, Kai Li, Matthew C Chambers, Daniel C Liebler, Bing Zhang Alternative splicing dramatically increases transcriptome complexity but its contribution to proteome diversity remains controversial. Exon-exon junction …


Cell Stem Cell: Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma

March 1, 2018

Madeline N Hayes 1, Karin McCarthy 1, Alexander Jin 1, Mariana L Oliveira 2, Sowmya Iyer 1, Sara P Garcia 1, Sivasish Sindiri 3, Berkley Gryder 3, Zainab Motala 4, G Petur Nielsen 5, Jean-Paul Borg 6, Matt van de Rijn 7, David Malkin 4, Javed Khan 3, M …


European Urology: Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide

February 10, 2018

Emmanuel S.Antonarakisab†, ChangxueLub†  BrandonLubera  ChaoLiangb  HaoWanga  YanChenb  John L.Silbersteinb DaniloPianab ZhaoLaic YidongChencd William B.Isaacsab JunLuoab Abstract Background Inherited DNA-repair gene mutations are more prevalent in men …


Cell Death & Disease: miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer

February 7, 2018

Xiaojie Yu, Yiqiang Zhang, David Cavazos, Xiuye Ma, Zhenze Zhao, Liqin Du & Alexander Pertsemlidis Abstract miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). Howev …


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