Greehey CCRI Archives
Scientific Reports: Genomic analyses of early responses to radiation in glioblastoma reveal new alterations at transcription, splicing, and translation levels
January 1, 2020Choudhary Saket, Suzanne C Burns, Mirsafian Hoda, Wenzheng Li, Dat T Vo, Qiao Mei, Lei Xiufen, Andrew D Smith, Luiz O Penalva High-dose radiation is the main component of glioblastoma therapy. Unfortunately, radio-resistance is a common problem and a m …
bioRxiv: Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches
January 1, 2020Sajina Shakya, Anthony D Gromovsky, James S Hale, Arnon M Knudsen, Briana Prager, Lisa C Wallace, Luiz OF Penalva, Pavlina Ivanova, H Alex Brown, Bjarne W Kristensen, Jeremy N Rich, Justin D Lathia, J Mark Brown, Christopher G Hubert Background: Gliobl …
BMG Genomics: An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data
December 30, 2019Li-Ju Wang, Catherine W. Zhang, Sophia C. Su, Hung-I H. Chen, Yu-Chiao Chiu, Zhao Lai, Hakim Bouamar, Amelie G. Ramirez, Francisco G. Cigarroa, Lu-Zhe Sun & Yidong Chen Abstract Background Europeans and American Indians were the major genetic ances …
Molecular Carcinogenesis: PELP1 signaling contributes to medulloblastoma progression by regulating the NF‐κB pathway
December 24, 2019Yiliao Luo Mengxing Li Uday P. Pratap Suryavathi Viswanadhapalli Junhao Liu Prabhakar P. Venkata Kristin A. Altwegg Bridgitte E. Palacios Xiaonan Li Yihong Chen Manjeet K. Rao Andrew J. Brenner Gangadhara R. Sareddy Ratna K. Vadlamud Abstract Medullobl …
NATURE: Bishop lab helps discovery of R-loops in the pediatric cancer Embryonal tumors with multilayered rosettes (ETMRs)
December 18, 2019Frontiers in Oncology: Nanoformulation of Talazoparib Increases Maximum Tolerated Doses in Combination With Temozolomide for Treatment of Ewing Sarcoma
December 17, 2019The Pediatric Preclinical Testing Program previously identified the PARP inhibitor talazoparib (TLZ) as a means to potentiate temozolomide (TMZ) activity for the treatment of Ewing sarcoma. However, the combination of TLZ and TMZ has been toxic in both …
Technology News Network: Team Develop Drugs To Fight Leukemia and Lymphoma
December 9, 2019UT Health San Antonio researchers, working with collaborators at the University of Florida, have discovered a safe and potent next generation of drugs to fight multiple types of leukemia and lymphoma in adults and children. The journal Nature Medicine …
Briefings in Bioinformatics: Deep learning of pharmacogenomics resources: moving towards precision oncology
December 8, 2019Yu-Chiao Chiu, Hung-I Harry Chen, Aparna Gorthi, Milad Mostavi, Siyuan Zheng, Yufei Huang, Yidong Chen Abstract The recent accumulation of cancer genomic data provides an opportunity to understand how a tumor’s genomic characteristics can affect its re …
BioNews Central: Leukemia, lymphoma squarely in sights of new class of drugs
December 6, 2019UT Health San Antonio researchers, working with collaborators at the University of Florida, have discovered a safe and potent next generation of drugs to fight multiple types of leukemia and lymphoma in adults and children. The journal Nature Medicine …
EurekAlert: Leukemia, lymphoma squarely in sights of new class of drugs
December 6, 2019UT Health San Antonio researchers, working with collaborators at the University of Florida, have discovered a safe and potent next generation of drugs to fight multiple types of leukemia and lymphoma in adults and children. The journal Nature Medicine …