Greehey CCRI News & Events Archive

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Genes & Cancer: The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma

November 7, 2015

David J. Elzi1, Meihua Song1, Peter J. Houghton1,2,3, Yidong Chen1,2,4, and Yuzuru Shiio1,2,5 ABSTRACT Ewing sarcoma is a cancer of the bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets famil …


Business Wire: Epizyme to Present New Scientific Data on the Role of HMT Inhibitors in Cancer

November 4, 2015

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Epizyme, Inc. (NASDAQ: EPZM), a clinical-stage biopharmaceutical company creating novel epigenetic therapies for cancer patients, will present data from 11 accepted abstracts on the role of histone methyltransferase ( …


Asian Pacific Journal of Cancer Prevention: Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia

November 1, 2015

Duangjai Piwkham 1, Teerapong Siriboonpiputtana, Joke Beuten, Samart Pakakasama, Jonathan Al Gelfond, Karan Paisooksantivatana, Gail E Tomlinson, Budsaba Rerkamnuaychoke Abstract Background: Folylpolyglutamate synthetase (FPGS), an important enzyme in …


PNAS: Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain

November 1, 2015

Gangadhara R. Sareddy, Quanguang Zhang, Ruimin Wang, Erin Scott, Yi Zou, Jason C. O’Connor, Yidong Chen, Yan Dong, Ratna K. Vadlamudi, and Darrell Brann Abstract 17-β estradiol (E2) has been implicated as neuroprotective in a variety of neurodegenerati …


Oncotarget: An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype

October 23, 2015

Ming-Kai Chuang1,*, Yu-Chiao Chiu2,5,*, Wen-Chien Chou1,3, Hsin-An Hou3, Mei-Hsuan Tseng3, Yi-Yi Kuo1,3, Yidong Chen5,6, Eric Y. Chuang2,4, Hwei-Fang Tien3 ABSTRACT Although clinical features, cytogenetics, and mutations are widely used to predict prog …


ASCI Post: Children’s Hospital of Philadelphia Is a Founding Member of the New Pediatric Preclinical Testing Consortium (Houghton mention)

October 10, 2015

Addressing the relatively small number of new cancer drugs for children, a selective group of leading research centers is joining a new federally funded research consortium aimed at bringing scientific rigor and a concentrated effort to identifying new …


Pediatric Blood & Cancer: Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma

October 1, 2015

Adam Studebaker 1, Kathryn Bondra 2, Star Seum 2, Changxian Shen 1, Doris A Phelps 1, Christopher Chronowski 2, Justin Leasure 2, Paul D Smith 3, Raushan T Kurmasheva 1, Xiaokui Mo 4, Maryam Fouladi 5, Peter J Houghton 1 Abstract Purpose: Curative ther …


NCI PPTC: Sarcoma and Renal Tumor Research Program

September 1, 2015

Dr. Peter Houghton, Dr. Raushan Kurmasheva (Co-Investigator)   Dr. Houghton is the Director of the Greehey Children’s Cancer Research Institute, which has as its mission to advance scientific knowledge relevant to childhood cancer and to accelerat …


Pediatric Blood & Cancer: Radiation therapy may increase metastatic potential in alveolar rhabdomyosarcoma

September 1, 2015

Gary M Woods # 1, Kathryn Bondra # 2, Christopher Chronowski 2, Justin Leasure 2, Mamata Singh 2, Lauren Hensley 2, Timothy P Cripe 1, Arnab Chakravarti 2, Peter Houghton 1 Abstract Background: We previously determined that radiation could be safely ad …


Frontiers in Oncology: Preclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and Validation

August 26, 2015

Over the past 35 years, cure rates for pediatric cancers have increased dramatically. However, it is clear that further dose intensification using cytotoxic agents or radiation therapy is not possible without enhancing morbidity and long-term effects. …


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