Greehey CCRI Archives
Pediatric Blood & Cancer: Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children’s Oncology Group Phase 1 Consortium study (ADVL1411)
November 14, 2019Abstract Purpose We conducted a phase 1/2 trial of the poly(ADP‐ribose) polymerase 1/2 inhibitor talazoparib in combination with low‐dose temozolomide (TMZ) to determine the dose‐limiting toxicities (DLTs), recommended phase 2 dose (RP2D), and pharmaco …
Aging Cell: mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
November 6, 2019Candice E. Van Skike, Ai‐Ling Lin, Raquel Roberts Burbank, Jonathan J. Halloran, Stephen F. Hernandez, James Cuvillier, Vanessa Y. Soto, Stacy A. Hussong, Jordan B. Jahrling, Martin A. Javors, Matthew J. Hart, Kathleen E. Fischer, Steven N. Austad, Ver …
Cell Reports: Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design
November 5, 2019Author links open overlay panelJo LynneRokita123 Komal S.Rathi23 Maria F.Cardenas4 Kristen A.Upton1 JoyJayaseelan4 Katherine L.Cross5 JacobPfeil6 Laura E.Egolf17 Gregory P.Way8 AlvinFarrel2 Nathan M.Kendsersky19 KhushbuPatel2 Krutika S.Gaon …
Neuro-Oncology Advances: PELP1 promotes glioblastoma progression by enhancing Wnt/β-catenin signaling
November 5, 2019Gangadhara R Sareddy 1 2, Uday P Pratap 1, Suryavathi Viswanadhapalli 1, Prabhakar Pitta Venkata 1, Binoj C Nair 1, Samaya Rajeshwari Krishnan 1, Siyuan Zheng 3 2, Andrea R Gilbert 4, Andrew J Brenner 5 2, Darrell W Brann 6, Ratna K Vadlamudi 1 2 Abstr …
Journal of Immunology: Immune Sensing of Aeroallergen-Associated Double-Stranded RNA Triggers an IFN Response and Modulates Type 2 Lung Inflammation
November 1, 2019Li She, Hamad H. Alanazi, Liping Yan, Yi Zou, Yilun Sun, Peter H. Dube, Edward G. Brooks, Gema D. Barrera, Zhao Lai, Yidong Chen, Yong Liu, Xin Zhang and Xiao-Dong Li Abstract The innate immune sensing of allergens or allergen-associated components reg …
MISSION MAGAZINE: Tiny molecule has big effect in childhood brain cancer (Rao Lab)
October 22, 2019Sometimes small things make the biggest difference. A new study has found that a molecule thousands of times smaller than a gene is able to kill medulloblastoma, the most common childhood brain cancer. This tiny molecule, named MiR-584-5p, is quite eff …
International Journal of Cancer: GD2‐directed CAR‐T cells in combination with HGF‐targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma
October 17, 2019Manish Charan, Piyush Dravid, Maren Cam, Anthony Audino, Amy C. Gross, Michael A. Arnold, Ryan D. Roberts, Timothy P. Cripe, Alexander Pertsemlidis, Peter J. Houghton, Hakan Cam Abstract Ewing sarcoma (EWS) is the second most common and aggressive typ …
Human Mutation: Clinical spectrum of individuals with pathogenic NF1 missense variants affecting p.Met1149, p.Arg1276, and p.Lys1423: genotype-phenotype study in neurofibromatosis type 1
October 8, 2019Magdalena Koczkowska 1, Tom Callens 1, Yunjia Chen 1, Alicia Gomes 1, Alesha D Hicks 1, Angela Sharp 1, Eric Johns 1, Kim Armfield Uhas 2, Linlea Armstrong 3, Katherine Armstrong Bosanko 4, Dusica Babovic-Vuksanovic 5, Laura Baker 6, Donald G Basel 7, …
Review article “Challenges and Opportunities for Childhood Cancer Drug Development” co-authored by Drs Kurmasheva and Houghton
October 3, 2019The review article “Challenges and Opportunities for Childhood Cancer Drug Development” co-authored by Raushan Kurmasheva, PhD and Peter Houghton, PhD has just been published.
Pharmacology Reviews: Challenges and Opportunities for Childhood Cancer Drug Development
October 1, 2019Peter J Houghton 1, Raushan T Kurmasheva 2 Abstract Cancer in children is rare with approximately 15,700 new cases diagnosed in the United States annually. Through the use of multimodality therapy (surgery, radiation therapy, and aggressive chemotherap …