Greehey CCRI Archives
UT Health SA Newsroom: Greehey Institute team finds link between BRCA1 and Ewing sarcoma
March 7, 2018A mutant oncogene in Ewing traps BRCA1 and prevents it from repairing genetic damage. Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRC …
EurekAlert: Greehey Institute team finds link between BRCA1 and Ewing sarcoma
March 7, 2018Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in t …
Life Extension Advocacy Foundation: Greehey Institute team finds link between BRCA1 and Ewing sarcoma
March 7, 2018Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in t …
Nature: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
March 7, 2018Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A. Lawrence, Elicia Goodale, Amanda Balboni Iniguez, Xavier Bernard, V. Pragathi Masamsetti, Sydney Roston, Elizabeth R. Lawlor, Jeffrey A. Toretsky, Kimberly Stegmaier, Stephen L. Lessnic …
Scientific Reports: Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity
March 6, 2018Bruna RS Correa, Joanna Hu, Luiz OF Penalva, Richard Schlegel, David L Rimm, Pedro AF Galante, Seema Agarwal Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug tar …
Molecular & Cellular Proteomics: Detection of proteome diversity resulted from alternative splicing is limited by trypsin cleavage specificity
March 1, 2018Xiaojing Wang, Simona G Codreanu, Bo Wen, Kai Li, Matthew C Chambers, Daniel C Liebler, Bing Zhang Alternative splicing dramatically increases transcriptome complexity but its contribution to proteome diversity remains controversial. Exon-exon junction …
Cell Stem Cell: Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma
March 1, 2018Madeline N Hayes 1, Karin McCarthy 1, Alexander Jin 1, Mariana L Oliveira 2, Sowmya Iyer 1, Sara P Garcia 1, Sivasish Sindiri 3, Berkley Gryder 3, Zainab Motala 4, G Petur Nielsen 5, Jean-Paul Borg 6, Matt van de Rijn 7, David Malkin 4, Javed Khan 3, M …
Cell: Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection
February 22, 2018Author links open overlay panelShen-YingZhang12339, Nathaniel E.Clark436, Catherine A.Freije536, Elodie Pauwels136Allison J.Taggart636, SatoshiOkada737, Hanna Mandel8937, PaulaGarcia1037, Michael J.Ciancanelli137, Anat Biran137, Fabien G.Lafaille137, M …
European Urology: Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide
February 10, 2018Emmanuel S.Antonarakisab†, ChangxueLub† BrandonLubera ChaoLiangb HaoWanga YanChenb John L.Silbersteinb DaniloPianab ZhaoLaic YidongChencd William B.Isaacsab JunLuoab Abstract Background Inherited DNA-repair gene mutations are more prevalent in men …
Cell Death & Disease: miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer
February 7, 2018Xiaojie Yu, Yiqiang Zhang, David Cavazos, Xiuye Ma, Zhenze Zhao, Liqin Du & Alexander Pertsemlidis Abstract miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). Howev …