Greehey CCRI News & Events Archive

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Annals of Human Genetics: Power of Genetic Association Studies with Fixed and Random Genotype Frequencies

August 15, 2010

Julia Kozlitina Chao Xing Alexander Pertsemlidis William R. Schucany Summary When estimating the power of genetic association studies, the allele and genotype frequencies are often assumed to be known, and the numbers of individuals with each genotype …


Nucleic Acids Research: PARP1 suppresses homologous recombination events in mice “in vivo”

July 21, 2010

Alison Claybon, Bijal Karia, Crystal Bruce, Alexander J. R. Bishop Abstract Recent studies suggest that PARP1 inhibitors, several of which are currently in a clinical trial, may selectively kill BRCA1/2 mutant cancer cells. It is thought that the succe …


Oncogene: MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers

July 5, 2010

J S Imam, K Buddavarapu, J S Lee-Chang, S Ganapathy, C Camosy, Y Chen & M K Rao Abstract Homeobox genes encode transcription factors that are essential for normal development and are often dysregulated in cancers. The molecular mechanisms that caus …


BMC: MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs

June 17, 2010

Liqin Du, Jeoffrey J Schageman, Irnov, Luc Girard, Scott M Hammond, John D Minna, Adi F Gazdar & Alexander Pertsemlidis Abstract Background Recent studies have shown that microRNAs (miRNAs) play roles in tumorigenesis and are reliable classifiers o …


BMC Systems Biology: Building and analyzing protein interactome networks by cross-species comparisons

March 30, 2010

Amy M Wiles, Mark Doderer, Jianhua Ruan, Ting-Ting Gu, Dashnamoorthy Ravi, Barron Blackman & Alexander JR Bishop Abstract Background A genomic catalog of protein-protein interactions is a rich source of information, particularly for exploring the r …


Breast Cancer Research Treatment: Occult ovarian cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers

February 24, 2010

Susan M Domchek 1, Tara M Friebel, Judy E Garber, Claudine Isaacs, Ellen Matloff, Rosalind Eeles, D Gareth Evans, Wendy Rubinstein, Christian F Singer, Stephen Rubin, Henry T Lynch, Mary B Daly, Jeffrey Weitzel, Patricia A Ganz, Gabriella Pichert, Oluf …


Pediatric Blood & Cancer: Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor

December 1, 2009

Tina T-L Chen 1, Dinesh Rakheja, Jaclyn Y Hung, Peter J Hornsby, Piotr Tabaczewski, Marcio Malogolowkin, James Feusner, Frank Miskevich, Roger Schultz, Gail E Tomlinson Abstract Background: Hepatoblastoma is a rare malignancy of childhood. The scarcity …


Breast Cancer Research Treatment: Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers

November 18, 2009

Amanda B Spurdle 1, Paul Fahey, Xiaoqing Chen, Lesley McGuffog, kConFab; Douglas Easton, Susan Peock, Margaret Cook, EMBRACE; Jacques Simard, INHERIT; Tim R Rebbeck, MAGIC; Antonis C Antoniou, Georgia Chenevix-Trench Abstract The GSTP1, GSTM1, and GSTT …


BMC Research: Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

October 20, 2009

Susan L Neuhausen 1, Sean Brummel, Yuan Chun Ding, Christian F Singer, Georg Pfeiler, Henry T Lynch, Katherine L Nathanson, Timothy R Rebbeck, Judy E Garber, Fergus Couch, Jeffrey Weitzel, Steven A Narod, Patricia A Ganz, Mary B Daly, Andrew K Godwin,  …


PLOS Genetics: A Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen

October 19, 2009

Dashnamoorthy Ravi, Amy M. Wiles, Selvaraj Bhavani, Jianhua Ruan, Philip Leder, Alexander J. R. Bishop  Abstract Damage initiates a pleiotropic cellular response aimed at cellular survival when appropriate. To identify genes required for damage surviva …


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