Greehey CCRI Archives
Nature: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma
March 7, 2018Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A. Lawrence, Elicia Goodale, Amanda Balboni Iniguez, Xavier Bernard, V. Pragathi Masamsetti, Sydney Roston, Elizabeth R. Lawlor, Jeffrey A. Toretsky, Kimberly Stegmaier, Stephen L. Lessnic …
Journal of Biological Chemistry: Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates
January 19, 2018Preston Countryman 1, Yanlin Fan 2, Aparna Gorthi 3 4, Hai Pan 1, Jack Strickland 1, Parminder Kaur 1, Xuechun Wang 5, Jiangguo Lin 1 6, Xiaoying Lei 2 7, Christian White 1, Changjiang You 8, Nicolas Wirth 9, Ingrid Tessmer 9, Jacob Piehler 8, Robert R …
Business Wire: Genomic Vision – Report of the LSR R&D Day
October 18, 2017Genomic Vision (Paris:GV) (Euronext: FR0011799907 – GV), a company specialized in the development of diagnostic tests for the early detection of cancers and genetic diseases, today reports of its second R&D Day which took place on October 16 in Par …
Genomic Vision: Report of the LSR R&D Day
October 18, 2017InderScience: Computational tools for genome-wide R-loops identification and characterization
April 15, 2017Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in various organisms and shown to play important roles in regulating gene expression, …
International Journal of Computational Biology and Drug Design: Computational tools for genome-wide R-loops identification and characterisation
April 15, 2017Authors: Rongjie Liu; Aparna Gorthi; Yufang Jin; Alexander J.R. Bishop; Yidong Chen Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in …
Molecular Cancer Therapeutics: Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis
December 1, 2016Alfeu Zanotto-Filho, V. Pragathi Masamsetti, Eva Loranc, Sonal S. Tonapi, Aparna Gorthi, Xavier Bernard, Rosângela Mayer Gonçalves, José C.F. Moreira, Yidong Chen and Alexander J.R. Bishop Abstract Alkylating agents are a commonly used cytotoxic class …
The American Journal of Pathology: Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit
September 1, 2016The conserved RNA-binding protein Musashi1 (MSI1) has been characterized as a stem cell marker, controlling the balance between self-renewal and differentiation and as a key oncogenic factor in numerous solid tumors, including glioblastoma. To explore …
Clinical Cancer Research: Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis
July 1, 2016Subapriya Rajamanickam, Subbarayalu Panneerdoss, Aparna Gorthi, Santosh Timilsina, Benjamin Onyeagucha, Dmytro Kovalsky, Dmitri Ivanov, Martha A. Hanes, Ratna K. Vadlamudi, Yidong Chen, Alexander J. Bishop, Jack L. Arbiser and Manjeet K. Rao Abstract P …
PLOS One: Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human
April 21, 2016Alfeu Zanotto-Filho, Ravi Dashnamoorthy, Eva Loranc, Luis H. T. de Souza, José C. F. Moreira, Uthra Suresh, Yidong Chen, Alexander J. R. Bishop Abstract Alkylating agents are a key component of cancer chemotherapy. Several cellular mechanisms are known …