Greehey CCRI Archives
PLOS One: Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human
April 21, 2016Alfeu Zanotto-Filho, Ravi Dashnamoorthy, Eva Loranc, Luis H. T. de Souza, José C. F. Moreira, Uthra Suresh, Yidong Chen, Alexander J. R. Bishop Abstract Alkylating agents are a key component of cancer chemotherapy. Several cellular mechanisms are know …
International Journal of Molecular Sciences (MDPI): Potential Relationship between Inadequate Response to DNA Damage and Development of Myelodysplastic Syndrome
January 5, 2015Ting Zhou 1,2,Peishuai Chen 1,3,Jian Gu 3,Alexander J. R. Bishop 1,2,4,5,Linda M. Scott 6,Paul Hasty 4,5,7 and Vivienne I. Rebel 1,2,4,5,* Abstract Hematopoietic stem cells (HSCs) are responsible for the continuous regeneration of all types of blood ce …
PLOS One: ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair
March 27, 2014Adam D. Brown, Brian W. Sager, Aparna Gorthi, Sonal S. Tonapi, Eric J. Brown, Alexander J. R. Bishop Abstract DNA replication fork stalling or collapse that arises from endogenous damage poses a serious threat to genome stability, but cells invoke an …
Proteome Science: Fully automated protein complex prediction based on topological similarity and community structure
November 7, 2013Chengwei Lei, Saleh Tamim, Alexander JR Bishop & Jianhua Ruan Abstract To understand the function of protein complexes and their association with biological processes, a lot of studies have been done towards analyzing the protein-protein interact …
DNA Repair: Induction of homologous recombination following in utero exposure to DNA-damaging agents
November 1, 2013Bijal Kariaab, Jo Ann Martinez, Alexander J.R.Bishop Abstract Much of our understanding of homologous recombination, as well as the development of the working models for these processes, has been derived from extensive work in model organisms, such as …
Experimental Hematology: Myelodysplastic syndrome: An inability to appropriately respond to damaged DNA?
August 1, 2013Author links open overlay panelTingZhouab PaulHastycde Christi A.Walterbdef Alexander J.R.Bishopabde Linda M.Scottg Vivienne I.Rebelabde Myelodysplastic syndrome (MDS) is considered a hematopoietic stem cell disease that is characterized by abnormal he …
Diabetes Journal: Enhanced NF-κB Activity Impairs Vascular Function Through PARP-1–, SP-1–, and COX-2–Dependent Mechanisms in Type 2 Diabetes
June 1, 2013Modar Kassan1,2, Soo-Kyoung Choi1, Maria Galán1,2, Alexander Bishop3, Kazuo Umezawa4, Mohamed Trebak5, Souad Belmadani2⇑ , and Khalid Matrougui1,2⇑ Abstract Type 2 diabetes (T2D) is associated with vascular dysfunction. We hypothesized that increased …
Mission Magazine: Hyundai Hope on Wheels Gives $250K to Support Childhood Leukemia Support
December 6, 2012Mission Magazine (UTHSA):
December 6, 2012BMC Genomics: Reducing confounding and suppression effects in TCGA data: an integrated analysis of chemotherapy response in ovarian cancer
October 26, 2012Fang-Han Hsu, Erchin Serpedin, Tzu-Hung Hsiao, Alexander JR Bishop, Edward R Dougherty & Yidong Chen Abstract Background Despite initial response in adjuvant chemotherapy, ovarian cancer patients treated with the combination of paclitaxel and carbo …