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PLOS GENETICS: Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent (Chen)

April 6, 2023

Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer Abstract Defective ribosome biogenesis (RiBi) underlies a group of clinically diverse human diseases collect …


Gear Up Against Kids Cancer bike race set for April 1

March 28, 2023

Posted on March 28, 2023, at 2:02 pm. Shared by Will Sansom Contact: Will Sansom, 210-567-2579, sansom@uthscsa.edu SAN ANTONIO (March 28, 2023) — The second Gear Up Against Kids Cancer bike race will take place this Saturday, April 1, in Wilson County. …


Luiz O.F. Penalva PhD to Receive ThriveWell Cancer Foundation, and IIMS / CTSA Grants

March 24, 2023

Grant Abstract: Ionizing radiation remains the mainstay of therapy for glioblastoma (GBM). We have recently found that senescent GBM cells that typically occur upon radiation can promote tumor recurrence via a process called “senescence escape.” These …


Neuro-Oncology: Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double strand break repair and augments efficacy of temozolomide in glioblastoma (Chen, Lai, Zheng Labs)

March 23, 2023

Salvador Alejo, Bridgitte E Palacios, Prabhakar Pitta Venkata, Yi He, Wenjing Li, Jessica D Johnson, Chen Yihong, Sridharan Jayamohan, Uday P Pratap, Kyra Clarke, Yi Zou, Yingli Lv, Korri Weldon, Suryavathi Viswanadhapalli, Zhao Lai, Zhenqing Ye, Yidon …


Biopolymers: Biochemical and biophysical characterization of the nucleic acid binding properties of the RNA/DNA binding protein EWS

March 21, 2023

Emily E. Selig,  Roohi Bhura,  Matthew R. White,  Shivani Akula,  Renee D. Hoffman,  Carmel N. Tovar,  Xiaoping Xu,  Rachell E. Booth,  David S. Libich Abstract EWS is a member of the FET family of RNA/DNA binding proteins that regulate crucial phases …


Cell Reports: Nitric Oxide Suppression by Secreted Frizzled-Related Protein 2 Drives Retinoblastoma (Shiio & Houghton Labs)

March 17, 2023

Panneerselvam Jayabal 1, Fuchun Zhou 1, Xiuye Ma 1, Kathryn M. Bondra 1, Barron Blackman 1, Susan T. Weintraub 2 3, Yidong Chen 1 3 4, Patricia Chévez-Barrios 5, Peter J. Houghton 1 3 6, Brenda Gallie 7, Yuzuru Shiio 1 2 3 8 Highlights The autocrine si …


Cancer Research: Sequential Targeting of Retinoblastoma and DNA Synthesis Pathways Is a Therapeutic Strategy for Sarcomas That Can Be Monitored in Real Time (Houghton)

March 15, 2023

Tuyen Duong;Thanh Nguyen; Yan Wang;  Tuyen N. Bui; Rossana Lazcano;  Davis R. Ingram;  Min Yi; Varshini Vakulabharanam; Linjie Luo; Marc A. Pina; Cansu Karakas ; Mi Li; Nicole M. Kettner; Neeta Somaiah; Peter J. Hougton; Osama Mawlawi; Alexander J. Laz …


Neuro-Oncology: Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double strand break repair and augments efficacy of temozolomide in glioblastoma (Chen Lab)

March 13, 2023

Salvador Alejo, Bridgitte E Palacios, Prabhakar Pitta Venkata, Yi He, Wenjing Li, Jessica D Johnson, Chen Yihong, Sridharan Jayamohan, Uday P Pratap, Kyra Abstract Background Efficient DNA repair in response to standard chemo and radiation therapies of …


BioPhysics Journal: Unraveling the phase separation of EWS low complexity domain using molecular dynamics simulations (Libich Lab)

March 3, 2023

Kandarp A. Sojitra 1, Courtney Johnson 2 3, Erich Sohn 2 3, David Libich 2 3, Jeetain Mittal 1 EWS, an RNA-binding protein, is responsible for gene expression, cell signaling, RNA processing, and transport. It is a member of the FET (FUS, EWS, TAF15) f …


Cancers Journal (MDPI) Guest Editor, Raushan Kurmasheva, PhD, invites relevant research work for publication.

February 24, 2023

Raushan Kurmasheva (Guest Editor) invites relevant research work for publication in a new Special Issue of the Cancers Journal (MDPI) titled “Pediatric Cancer: From Molecular Targets to Effective Therapies.” Please, find more information here:https://w …