Biochemistry: The Spliceosomal Peptidyl Prolyl Isomerase Like 1 Interacts with the Low-Complexity Domain of the RNA Binding Protein EWS Modulating Its Phase Separation Behavior (Libich Lab)
August 8, 2025George L Parra 1, Erich J Sohn 1, Xiaoping Xu 1, David S Libich 1 Abstract RNA-binding protein EWS, a member of the FET (FUS, EWS, TAF15) family, contributes to mRNA biogenesis through roles in transcription, splicing, and RNA transport. Despite eviden …
UT Health San Antonio gears up to drive out childhood cancer (Hyundai Hope on Wheels Media Advisory)
August 5, 2025FOR IMMEDIATE RELEASE August 5, 2025 Contact: Eileen Teves, 210-450-7239, tevese@uthscsa.edu MEDIA ADVISORY UT Health San Antonio gears up to drive out childhood cancer Receives grant from Hyundai Hope on Wheels® to continue its fight against the disea …
Molecular Cell: PALB2 and 53BP1 govern post-resection homologous recombination DNA repair (Sung Lab)
August 4, 2025Yifan Wang 1, Yan Coulombe 2,Wei-Ting Yueh 1,Gregory D. Conway 1,Larissa Milano 2,David J. Glass 1 3,Mélissa Thomas 2,Amélie Rodrigue 2,Joseph Nacson 1,Dongbo Lu 4,Andrea J. Bernhardy 1, Robert G. Betsch 1,Alyssa I. Russo 1,Gamal A. Elfar 1,Kathy Q. Ca …
Journal of Applied Physiology: Evaluating the effects of exercise and phellodendron amurense on cardiac function in a prostate cancer mouse model (Aune Lab)
August 4, 2025Neha Kumar, Logan R. Davis, Gregory J. Aune Paul Rivas, Addanki P. Kumar, Darpan I. Patel Abstract Cytotoxic treatments pose a significant cardiotoxic risk to men with prostate cancer (PCa). Exercise has been found to prevent cardiotoxicities. Previous …
Cancer Epidemiology Biomarkers Prevention: Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma (Tomlinson)
August 1, 2025Tiankai Xie Josey C. Sorenson Logan G. Spector Nathan Pankratz R. Stephanie Huang Eiso Hiyama Jenny N. Poynter Gail E. Tomlinson Carolina Armengol Roland Kappler Michael E. Scheurer Eve Roman Aurora Castellano Michael A. Grotzer David S. Ziegler Saonli …
Journal of Clinical Investigation: Efficacy and safety of a therapeutic humanized FSH–blocking antibody in obesity and Alzheimer’s disease models (Gupta)
July 30, 2025Anusha R. Pallapati,1 Funda Korkmaz,1 Satish Rojekar,1 Steven Sims,1 Anurag Misra,2 Judit Gimenez–Roig,1 Aishwarya Gangadhar,1 Victoria Laurencin,1 Anissa Gumerova,1 Uliana Cheliadinova,1 Farhath Sultana,1 Darya Vasilyeva,1 Liam Cullen,1 Jonathan Schue …
Computational & Structural Biotechnology: Cell type prediction with neighborhood-enhanced cellular embedding using deep learning on hematoxylin and eosin-stained images (Chen Lab)
July 30, 2025Nam Nhut Phana ∙ Hanzhou Wanga ∙ Tapsya Nayaka ∙ Zhenqing Yea ∙ Yu-Chiao Chiub,c ∙ Yufang Jind ∙ Yufei Huangc,e,f ∙ Yidong Chena,g cheny8@uthscsa.edu Abstract Purpose This study aimed to predict the cell types that infiltrate the tumor microenvironmen …
Cell Reports: IGSF10 is a RET antagonist regulating Ewing sarcoma growth and GnRH neuron migration (Chen, Houghton, & Shiio Lab)
July 24, 2025Panneerselvam Jayabal1 ∙ Xiuye Ma1 ∙ Maleeha Akram2 ∙ Hannah Bow2 ∙ Pranay Mandal2 ∙ Naira Mansano2 ∙ Yidong Chen1,3,4 ∙ Susan T. Weintraub4,5 ∙ Peter J. Houghton1,4,6 ∙ Susan Wray2 ∙ Yuzuru Shiio Highlights Ewing sarcoma depends on IGSF10, which inhib …
UT Health San Antonio scientists uncover how some cancers outsmart immune system (Rao, Sung, Zheng, & Chen Labs)
July 17, 2025Shared By: Claire Kowalick July 17, 2025 FOXM1 protein identified as key driver in immunotherapy resistance, unlocking new therapeutic avenues For years, scientists have found the overexpression of a specific protein called FOXM1 in a wide range of c …
Biochemistry: The Spliceosomal Peptidyl Prolyl Isomerase Like 1 Interacts with the Low-Complexity Domain of the RNA Binding Protein EWS Modulating Its Phase Separation Behavior (Libich Lab)
July 17, 2025Abstract RNA binding protein EWS, a member of the FET (FUS, EWS, TAF15) family, contributes to mRNA biogenesis through roles in transcription, splicing, and RNA transport. Despite evidence linking EWS to spliceosomal complexes, its interactions with sp …