Greehey CCRI News & Events Archive

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Genome Biology: Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma

December 1, 2016

Bruna R Correa, Patricia Rosa de Araujo, Mei Qiao, Suzanne C Burns, Chen Chen, Richard Schlegel, Seema Agarwal, Pedro AF Galante, Luiz OF Penalva Background Glioblastoma (GBM) is the most common and aggressive type of brain tumor. Currently, GBM has an …


Molecular Cancer Therapeutics: Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis

December 1, 2016

Alfeu Zanotto-Filho, V. Pragathi Masamsetti, Eva Loranc, Sonal S. Tonapi, Aparna Gorthi, Xavier Bernard, Rosângela Mayer Gonçalves, José C.F. Moreira, Yidong Chen and Alexander J.R. Bishop Abstract Alkylating agents are a commonly used cytotoxic class …


Aging: Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential

November 15, 2016

Qiaoxiang Dong1,2 , Hui Gao1,2 , Yuanshuo Shi1,3 , Fuchuang Zhang1,3 , Xiang Gu1 , Anqi Wu3 , Danhan Wang3 , Yuanhong Chen3 , Abhik Bandyopadhyay1 , I-Tien Yeh4 , Benjamin J. Daniel5 , Yidong Chen6,8 , Yi Zou8 , Vivienne L. Rebel1,7,8 , Christi A. Walt …


Scientific Reports: Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers

November 12, 2016

Tzu-Hung Hsiao, Yu-Chiao Chiu, Pei-Yin Hsu, Tzu-Pin Lu, Liang-Chuan Lai, Mong-Hsun Tsai, Tim H.-M. Huang, Eric Y. Chuang Yidong Chen Abstract Several mutual information (MI)-based algorithms have been developed to identify dynamic gene-gene and functio …


JoVE: Methyl-binding DNA capture Sequencing for Patient Tissues

October 31, 2016

Rohit R Jadhav 1, Yao V Wang 1, Ya-Ting Hsu 1, Joseph Liu 1, Dawn Garcia 2, Zhao Lai 2, Tim H M Huang 1, Victor X Jin 3 Abstract Methylation is one of the essential epigenetic modifications to the DNA, which is responsible for the precise regulation of …


Hepatology: Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups

October 24, 2016

Pavel Sumazin, Yidong Chen, Lisa R. Treviño Stephen F. Sarabia Oliver A. Hampton Kayuri Patel Toni‐Ann Mistretta Barry Zorman Patrick Thompson Andras Heczey Sarah Comerford David A. Wheeler Murali Chintagumpala Rebecka Meyers Dinesh Rakheja Milton J. F …


Oncotarget: A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells

October 15, 2016

Zhenze Zhao1, Xiuye Ma2, Spencer D. Shelton1, Derek C. Sung3, Monica Li4, Daniel Hernandez5, Maggie Zhang6, Michael D. Losiewicz7, Yidong Chen8, Alexander Pertsemlidis2,9,10, Xiaojie Yu11, Yuanhang Liu11, Liqin Du1 ABSTRACT MYCN amplification is the mo …


Bexar County Medical Society: San Antonio Medicine October 2016

October 1, 2016


Cancer Research: Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis

October 1, 2016

Brendan Murphy 1, Han Yin 1, John M Maris 2, E Anders Kolb 3, Richard Gorlick 4, C Patrick Reynolds 5, Min H Kang 6, Stephen T Keir 7, Raushan T Kurmasheva 8, Igor Dvorchik 9, Jianrong Wu 10, Catherine A Billups 10, Nana Boateng 10, Malcolm A Smith 11, …


Pediatric Blood & Cancer: Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program

September 21, 2016

Richard Lock 1, Hernan Carol 1, John M Maris 2, E Anders Kolb 3, Richard Gorlick 4, C Patrick Reynolds 5, Min H Kang 5, Stephen T Keir 6, Jianrong Wu 7, Andrei Purmal 8, Andrei Gudkov 9, Dias Kurmashev 10, Raushan T Kurmasheva 10, Peter J Houghton 10,  …


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