Greehey CCRI News & Events Archive
Pediatric Blood & Cancer: Radiation therapy may increase metastatic potential in alveolar rhabdomyosarcoma
September 1, 2015Gary M Woods # 1, Kathryn Bondra # 2, Christopher Chronowski 2, Justin Leasure 2, Mamata Singh 2, Lauren Hensley 2, Timothy P Cripe 1, Arnab Chakravarti 2, Peter Houghton 1 Abstract Background: We previously determined that radiation could be safely ad …
Frontiers in Oncology: Preclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and Validation
August 26, 2015Over the past 35 years, cure rates for pediatric cancers have increased dramatically. However, it is clear that further dose intensification using cytotoxic agents or radiation therapy is not possible without enhancing morbidity and long-term effects. …
Pathobiology of Aging & Age-related Diseases: Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy
August 24, 2015Xiang Bai, Margaret Chia-Ying Wey, Elizabeth Fernandez, Matthew J. Hart, Jonathan Gelfond, Alex F. Bokov, Sheela Rani & Randy Strong Abstract Background Synucleinopathy is any of a group of age-related neurodegenerative disorders including Parkinso …
Molecular Cancer Research: ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM
August 1, 2015Xue-Song Liu, Matthew D. Genet, Jenna E. Haines, Elie K. Mehanna, Shaowei Wu, Hung-I Harry Chen, Yidong Chen, Abrar A. Qureshi, Jiali Han, Xiang Chen, David E. Fisher, Pier Paolo Pandolfi, and Zhi-Min Yuan Abstract The excessive metastatic propensity o …
National Coalition for Cancer Survivorship: Guest Post: Oncologist and Cancer Survivor Greg Aune Talks Multi-Disciplinary Care
July 31, 2015The Importance of Multidisciplinary Survivorship Care and Research Post by Greg Aune, MD, PhD, Greehey Children’s Cancer Research Institute, Univ. of Texas Health Science Center at San Antonio Survivors of cancer are a growing population in the United …
Biology of Reproduction: Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice
July 1, 2015Joshua P. Welborn, Matthew G. Davis, Steven D. Ebers, Genna R. Stodden, Kanako Hayashi, Joseph L. Cheatwood, Manjeet K. Rao, James A. MacLean, II Abstract The reproductive homeobox X-linked, Rhox, genes encode transcription factors that are selectively …
BMC Genomics: Co-modulation analysis of gene regulation in breast cancer reveals complex interplay between ESR1 and ERBB2 genes
June 11, 2015Yu-Chiao Chiu, Chin-Ting Wu, Tzu-Hung Hsiao, Yi-Pin Lai, Chuhsing Kate Hsiao, Yidong Chen & Eric Y Chuang Abstract Background Gene regulation is dynamic across cellular conditions and disease subtypes. From the aspect of regulation under modulation …
BMC Genomics: Education, collaboration, and innovation: intelligent biology and medicine in the era of big data
June 11, 2015Jianhua Ruan, Victor Jin, Yufei Huang, Hua Xu, Jeremy S Edwards, Yidong Chen & Zhongming Zhao Abstract Here we present a summary of the 2014 International Conference on Intelligent Biology and Medicine (ICIBM 2014) and the editorial report of the s …
BMC Genomics: Differential expression analysis of RNA sequencing data by incorporating non-exonic mapped reads
June 11, 2015Hung-I Harry Chen, Yuanhang Liu, Yi Zou, Zhao Lai, Devanand Sarkar, Yufei Huang & Yidong Chen Abstract Background RNA sequencing (RNA-seq) is a powerful tool for genome-wide expression profiling of biological samples with the advantage of high-thro …
Endocrine-Related Cancer: Integrity of the pheochromocytoma susceptibility TMEM127 gene in patients with pediatric malignancies
June 1, 2015Authors: E E King 1 , Y Qin 1 , R A Toledo 1 , A Luo 1 , E Ball 1 , F R Faucz 1 , K A Janeway1 , C A Stratakis 1 , G E Tomlinson 1 , 1 , 1 , and P L M Dahia 1 , 1 , 1 Dear Editor, Germline mutations of the tumor suppressor gene TMEM127 occur in the neu …