Greehey CCRI News & Events Archive

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Transnational Cancer Research: Chain-reaction, a model of gene expression dynamics

June 21, 2012

Submitted May 21, 2012. Accepted for publication Jun 21, 2012. doi: 10.3978/j.issn.2218-676X.2012.06.01 One of the fundamental studies of transcription response to stimuli is to model the activation, repression of hundreds of genes, and their regulatio …


Science: Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

April 13, 2012

In Hye Lee1, Yoshichika Kawai1, Maria M. Fergusson1, Ilsa I. Rovira1, Alexander J. R. Bishop2, Noboru Motoyama3, Liu Cao4,*, Toren Finkel1,* Starvation and Autophagy Starvation stimulates withdrawal from the cell cycle, as well as stimulating autophagy …


Experimental Hematology: Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm

April 1, 2012

Author links open overlay panelStephanie N.Zimmerab∗  Madeleine E.Lemieuxc∗  Bijal P.Kariaab  ClaudiaDayb  TingZhouab  QingZhoub  Andrew L.Kungc  UthraSuresh  bYidongChenbd  Marsha C.Kinneye  Alexander J.R.Bishopab  Vivienne I.Rebel Myelodysplastic syn …


UT Health SA Newsroom: CPRIT awards $4.7 million to Health Science Center

January 18, 2012

Two University of Texas Health Science Center at San Antonio researchers today were awarded a total of $4.7 million by the Cancer Prevention and Research Institute of Texas (CPRIT). These awards for cancer prevention, along with $2.9 million to Univers …


Gastroenterology: Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival

December 3, 2011

Background & Aims Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers ass …


Journal of Biological Chemistry: Mutant p53 Disrupts Role of ShcA Protein in Balancing Smad Protein-dependent and -independent Signaling Activity of Transforming Growth Factor-β (TGF-β)*

October 26, 2011

Shu Lin‡, Lan Yu‡, Junhua Yang‡, Zhao Liu‡, Bijal Karia‡§, Alexander J. R. Bishop‡§¶, James Jackson‖, Guillermina Lozano‖, John A. Copland**, Xiaoxin Mu‡‡‡, Beicheng Sun‡‡ and Lu-Zhe Sun‡¶,1 Abstract Biomarkers are lacking for identifying the switch of …


IEEE: Stochastic Modeling of the Relationship between Copy Number and Gene Expression Based on Transcriptional Logic

October 24, 2011

Fang-Han Hsu; Erchin Serpedin; Yidong Chen; Edward R. Dougherty Abstract: DNA copy number alterations (CNAs) can cause genetic diseases, and studies have revealed a relationship between CNAs and gene expression; however, the manner in which CNAs relate …


Molecular Profiling: Genome-Wide Methylation Profiling in Archival Formalin-Fixed Paraffin-Embedded Tissue Samples

October 21, 2011

J. Keith Killian, Robert L. Walker, Sven Bilke, Yidong Chen, Sean Davis, Robert Cornelison, William I. Smith, Paul S. Meltzer Abstract New technologies allow for the genome-scale measurement of DNA methylation. In an effort to increase the clinical uti …


Proteome Science: Bayesian non-negative factor analysis for reconstructing transcription factor mediated regulatory networks

October 14, 2011

Jia Meng, Jianqiu (Michelle) Zhang, Yidong Chen & Yufei Huang Abstract Background Transcriptional regulation by a transcription factor (TF) controls the time and abundance of mRNA transcription. Due to the limitation of current proteomics technolog …


BMC Research Notes: A model-based circular binary segmentation algorithm for the analysis of array CGH data

October 10, 2011

Fang-Han Hsu, Hung-I H Chen, Mong-Hsun Tsai, Liang-Chuan Lai, Chi-Cheng Huang, Shih-Hsin Tu, Eric Y Chuang & Yidong Chen Abstract Background Circular Binary Segmentation (CBS) is a permutation-based algorithm for array Comparative Genomic Hybridiza …