Greehey CCRI Archives
JAMA Oncology: Derivation of Anthracycline and Anthraquinone Equivalence Ratios to Doxorubicin for Late-Onset Cardiotoxicity
January 31, 2019Elizabeth A. M. Feijen, PhD1,2; Wendy M. Leisenring, ScD3,4; Kayla L. Stratton, MS3,4; Kirsten K. Ness, PT, PhD5; Helena J. H. van der Pal, MD, PhD2; Elvira C. van Dalen, MD, PhD1,2; Gregory T. Armstrong, MD, MSCE5; Gregory J. Aune, MD, PhD6; Daniel M. …
EurekAlert: Do all chemotherapies have equal long-term heart risk?
January 21, 2019SAN ANTONIO — In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published Jan. 31 in JAMA Oncology, researchers compared four chemotherapy drugs with the develo …
MDPI: CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere
January 15, 2019Yohei Niikura 1,2,* Risa Kitagawa 1 and Katsumi Kitagawa 1,* Abstract The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centr …
PLOS Computational Biology: Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods
January 2, 2019Song-Yao Zhang, Shao-Wu Zhang, Xiao-Nan Fan, Jia Meng, Yidong Chen, Shou-Jiang Gao, Yufei Huang Abstract N6-methyladenosine (m6A) is the most abundant methylation, existing in >25% of human mRNAs. Exciting recent discoveries indicate the close invol …
BMC Systems Biology: GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization
December 21, 2018Hung-I Harry Chen, Yu-Chiao Chiu, Tinghe Zhang, Songyao Zhang, Yufei Huang & Yidong Chen Abstract Background Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set-based analyses improve …
BMC Systems Biology: scdNet: a computational tool for single-cell differential network analysis
December 21, 2018Yu-Chiao Chiu, Tzu-Hung Hsiao, Li-Ju Wang, Yidong Chen & Yu-Hsuan Joni Shao Abstract Background Single-cell RNA sequencing (scRNA-Seq) is an emerging technology that has revolutionized the research of tumor heterogeneity. However, the highly sparse …
PLoS One: microRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi
December 14, 2018Zhenze Zhao, Veronica Partridge, Michaela Sousares, Spencer D. Shelton, Cory L. Holland, Alexander Pertsemlidis, Liqin Du Abstract microRNA-2110 (miR-2110) was previously identified as inducing neurite outgrowth in neuroblastoma cell lines BE(2)-C, su …
KLRN Sponsorship: Molecule – Greehey Children’s Cancer Research Institute (TV spot)
December 14, 2018University of Texas Health Science Center at San Antonio – UT Health San Antonio, “Non-Hodgkin Lymphoma: David Seitze”
December 12, 2018https://www.youtube.com/watch?v=y18yUNT98h8 UT Health San Antonio MD Anderson Cancer Center’s mission is to conquer cancer through research, prevention, and treatment—while offering world-class care close to home for patients in South Texas. How do ide …
Tiny molecule has big effect in childhood brain tumor studies
December 6, 2018Sometimes small things make the biggest difference. A new study by UT Health San Antonio researchers found that a molecule thousands of times smaller than a gene are able to kill medulloblastoma, the most common childhood brain cancer.