Dr. Gupta to Present at Cold Spring Harbor Laboratory Meeting on Eukaryotic mRNA Processing, August 22-26, 2023

Published On: August 2, 2023
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Click on image below for full agenda _________________________________________________________ Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to understanding its causes, and accelerate the translation of knowledge into novel therapies. Greehey CCRI strives to have a national and global impact on [...] Read more

Nucleic Acids Research: TLK1-Mediated RAD54 Phosphorylation Spatio-Temporally Regulates Homologous Recombination Repair (Chen, Sung)

Published On: July 13, 2023
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Ishita Ghosh, Youngho Kwon, Aida Badamchi Shabestari, Rupesh Chikhale, Jing Chen, Claudia Wiese, Patrick Sung, Arrigo De Benedetti Abstract Environmental agents like ionizing radiation (IR) and chemotherapeutic drugs can cause severe damage to the DNA, often in the form of double-strand breaks (DSBs). Remaining unrepaired, DSBs can lead to chromosomal rearrangements and cell death. One major error-free pathway to repair DSBs is homologous [...] Read more

Midwest AViDD Center announces funding for six high-potential projects to further antiviral drug discovery (Gupta Lab et al)

Published On: July 10, 2023
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MINNEAPOLIS/ST. PAUL (07/05/2023) – To accelerate the Midwest Antiviral Drug Discovery (AViDD) Center's mission to develop therapeutics for viruses with pandemic potential, the Center today announced $3 million in funding for six additional projects over the next two years. The projects will expand the Center's expertise across disciplines to discover effective responses to pandemics, life-threatening infections, [...] Read more

Pediatric Hematology & Oncology: Circulating tumor DNA sequencing of pediatric solid and brain tumor patients: An institutional feasibility study (Tomlinson)

Published On: June 27, 2023
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Ross Mangum, Jacquelyn Reuther ,Koel Sen Baksi Ilavarasi Gandhi, Ryan C. Zabriskiec, Alva Recinos, , Robin Raesz-Martinez, Frank Y. Lin, Samara L. Potter, Andrew C. Sher, Stephen F. Kralik, Carrie A. Mohila, Murali M. Chintagumpala, Donna Muzny, Jianhong Hu, Richard A. Gibbs, Kevin E. Fisher Juan Carlos Bernini, Jonathan Gill, Timothy C. Griffin, Gail E. Tomlinson, [...] Read more

Bioinformatics Advances: DepLink: an R Shiny app to systematically link genetic and pharmacologic dependencies of cancer (Zheng, Houghton, & Chen Labs)

Published On: June 27, 2023
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Tapsya Nayak, Li-Ju Wang, Michael Ning, Gabriela Rubannelsonkumar, Eric Jin, Siyuan Zheng, Peter J Houghton, Yufei Huang, Yu-Chiao Chiu, Yidong Chen Abstract Motivation Large-scale genetic and pharmacologic dependency maps are generated to reveal genetic vulnerabilities and drug sensitivities of cancer. However, user-friendly software is needed to link such maps systematically. Results Here, we present DepLink, a web server to identify genetic and pharmacologic perturbations [...] Read more

Nature: Structural Insights into BCDX2 Complex Function in Homologous Recombination (Sung Lab)

Published On: June 22, 2023
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Yashpal Rawal, Lijia Jia, Aviv Meir, Shuo Zhou, Hardeep Kaur, Eliza A. Ruben, Youngho Kwon, Kara A. Bernstein, Maria Jasin, Alexander B. Taylor, Sandeep Burma, Robert Hromas, Alexander V. Mazin, Weixing Zhao, Daohong Zhou, Elizabeth V. Wasmuth, Eric C. Greene, Patrick Sung & Shaun K. Olsen Abstract Homologous recombination (HR) fulfils a pivotal role in the [...] Read more

NAR Cancer: The 3D Chromatin Landscape of Rhabdomyosarcoma (Ignatius Lab)

Published On: June 16, 2023
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  Meng Wang, Prethish Sreenivas, Benjamin D Sunkel, Long Wang, Myron Ignatius, Benjamin Z Stanton Abstract Rhabdomyosarcoma (RMS) is a pediatric soft tissue cancer with a lack of precision therapy options for patients. We hypothesized that with a general paucity of known mutations in RMS, chromatin structural driving mechanisms are essential for tumor proliferation. Thus, we carried out high-depth in situ Hi-C in [...] Read more

Katsumi Kitagawa, Pharm.D., PhD, to Receive NIH Grant to study “The Role of EWSR1 at the Centromere.”

Published On: June 16, 2023
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Abstract Text The centromere is a unique chromosomal region that is essential for high-fidelity chromosome transmission during cell division. In mitosis, microtubules attached to the kinetochore help ensure the faithful segregation of sister chromatids into daughter cells. Our goal is to understand the mechanisms that govern centromere function. Centromere identity relies on the deposition of [...] Read more

Nature: Break-induced replication orchestrates resection-dependent template switching (Sung)

Published On: June 15, 2023
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Tianpeng Zhang, Yashpal Rawal, Haoyang Jiang, Youngho Kwon, Patrick Sung & Roger A. Greenberg Abstract Break-induced telomere synthesis (BITS) is a RAD51-independent form of break-induced replication that contributes to the alternative lengthening of telomeres1,2. This homology-directed repair mechanism utilizes a minimal replisome comprising proliferating cell nuclear antigen (PCNA) and DNA polymerase-δ to execute conservative DNA repair [...] Read more

RNA Biology: The Paralogues MAGOH and MAGOHB are Oncogenic Factors in High-Grade Gliomas and Safeguard the Splicing of Cell Division and Cell Cycle Genes (Penalva Lab)

Published On: June 9, 2023
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Rodrigo A. S. Barreiro, Gabriela D. A. Guardia, Fabiana M. Meliso, Xiufen Lei, Wei-Qing Li, Andre Savio, Martin Fellermeyer, Helena B. Conceição, Rafael L. V. Mercuri, Tesha Landry, Mei Qiao, Lorea Blazquez, Jernej Ule, Luiz O.F. Penalva & Pedro A. F. Galante ABSTRACT The exon junction complex (EJC) plays key roles throughout the lifespan of [...] Read more