Journal of Clinical Oncology: The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer (Aune Co-author)

Published On: June 5, 2023
Shared by

Joseph A. Flores-Toro  , PhD1; Subhashini Jagu  , PhD1; Gregory T. Armstrong, MD, MSCE2; David F. Arons, JD3; Gregory J. Aune, MD, PhD4; Stephen J. Chanock  , MD1; Douglas S. Hawkins  , MD5; Allison Heath  , PhD6; Lee J. Helman  , MD7; Katherine A. Janeway  , MD, MMSc8; Jason E. Levine  , MD1; Ellyn Miller, [...] Read more

Panneerdoss Subbarayalu, PhD, to receive NIH, NCI R21 Grant, “Targeting the RNA Modifying Enzyme ALKBH5 in Medulloblastoma

Published On: June 5, 2023
Shared by

Project Title: Targeting the RNA modifying enzyme ALKBH5 in Medulloblastoma Principal Investigator: Panneerdoss Subbarayalu Co-Investigators: Manjeet Rao, PhD, Andrew Brenner, MD, PhD., Peter Houghton, PhD. Funding Agency: National Institutes of Health, NATIONAL CANCER INSTITUTE Medulloblastoma is the most common malignant brain cancer in children. Despite the progress in treating medulloblastoma, the 5-year survival rate for high-risk [...] Read more

ELife: Defining function of wild-type and three patient specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma (Ignatius Lab, Houghton Lab, Libich Lab, Chen, Tomlinson)

Published On: June 2, 2023
Shared by

Jiangfei Chen Kunal Baxi Amanda E Lipsitt Nicole Rae Hensch Long Wang Prethish Sreenivas Paulomi Modi Xiang Ru Zhao Antoine Baudin Daniel G Robledo Abhik Bandyopadhyay Aaron Sugalski Anil K Challa Dias Kurmashev Andrea R Gilbert Gail E Tomlinson Peter Houghton Yidong Chen Madeline N Hayes Eleanor Y Chen David S Libich Myron S Ignatius [...] Read more

Cell Reports: EWSR1 Maintains Centromere Identity (Kitagawa & Houghton labs)

Published On: May 30, 2023
Shared by

Risa Kitagawa 1, Yohei Niikura 1 2, Argentina Becker 1 3, Peter J. Houghton 1, Katsumi Kitagawa 1 4 Highlights EWSR1 is required to maintain CENP-A at the centromere in interphase cells EWSR1 binds to CENP-A through the SYGQ2 region, important for phase separation EWSR1 binds to R loops in vitro through its RNA-recognition motif (RRM) EWSR1 protects CENP-A in the centromeric chromatin by binding to centromeric RNAs Summary The centromere is essential [...] Read more

Clinical Cancer Research: Phase II Investigation of TVB-2640 (Denifanstat)with Bevacizumabin Patients with First Relapse High-Grade Astrocytoma (Chen)

Published On: May 24, 2023
Shared by

William Kelly 1, Adolfo Enrique Diaz Duque 1,Joel Michalek 2, Brandon Konkel 3,L aura Caflisch 3, Yidong Chen 2,Sarath Chand Pathuri 1,Vinu Madhusudanannair-Kunnuparampil 4, John Floyd II 5,and Andrew Brenner 1 ABSTRACT Purpose: Glioblastoma represents the most common primary brain tumor. Although antiangiogenics are used in the recurrent setting, they do not prolong survival. Glioblastoma [...] Read more

Biomolecules: Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis (Libich Lab)

Published On: May 17, 2023
Shared by

Samjhana Pandey Krishna K. Raut Andrea M. Clark  Antoine Baudin  Lamya Djemri  David S. Libich  Komala Ponniah Steven M. Pascal Abstract Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4), an approximately 40-kilodalton proapoptotic tumor suppressor, is a predominantly intrinsically disordered [...] Read more

Cells: The RNA Demethylase ALKBH5 Maintains Endoplasmic Reticulum Homeostasis by Regulating UPR, Autophagy, and Mitochondrial Function (Chen, Sung, & Rao Labs)

Published On: May 17, 2023
Shared by

Panneerdoss Subbarayalu Pooja Yadav Santosh Timilsina Daisy Medina Kunal Baxi Robert Hromas Ratna K. Vadlamudi Yidong Chen Patrick Sung Manjeet K. Rao Abstract Eukaryotic cells maintain cellular fitness by employing well-coordinated and evolutionarily conserved processes that negotiate stress induced by internal or external environments. These processes include the unfolded protein response, autophagy, endoplasmic reticulum-associated degradation [...] Read more

Paulomi Modi (Ignatius Lab) Recognized as 2023 Presidential Ambassador Scholar

Published On: May 8, 2023
Shared by

Ambassadors from left to right: Gina Baxter (SHP), Avani Ved (SON), Paulomi Modi (GSBS), Alejandra Garcia (LSOM) and Tyler Childs (SOD) Paulomi Modi is a second-year PhD student in the Integrated Biomedical Sciences program at the Graduate School of Biomedical Sciences.  At 17, Modi moved to the United States on her own and later graduated [...] Read more

Thrombosis Research: A cohort study on blood coagulation in childhood cancer survivors (Aune)

Published On: May 5, 2023
Shared by

                  Andrew D. Meyer a, Tyler B. Hughes a, Anjana R. Rishmawi a, Patty Heard a, Shafqat Shah b, Gregory J. Aune b c Highlights Anticoagulants decrease thrombotic events in adults receiving cancer therapy. Survivors of childhood cancer have an increased risk of a thromboembolic stroke. Elevated coagulation protein levels are sensitive biomarkers of thrombosis risk. Our study identified that childhood survivors have chronically elevated [...] Read more

Advanced Science: Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis (Bishop)

Published On: April 26, 2023
Shared by

Mingli Li, Lu Yang, Anthony K. N. Chan, Sheela Pangeni Pokharel, Qiao Liu, Nicole Mattson, Xiaobao Xu, Wen-Han Chang, Kazuya Miyashita, Priyanka Singh, Leisi Zhang, Maggie Li, Jun Wu, Jinhui Wang, Bryan Chen, Lai N. Chan, Jaewoong Lee, Xu Hannah Zhang, Steven T. Rosen, Markus Müschen, Jun Qi, Jianjun Chen, Kevin Hiom, Alexander J. R. Bishop, Chun-Wei Chen … See fewer authors  First published: 19 April 2023   Abstract Epigenetic dysregulation is reported in multiple cancers, including Ewing sarcoma (EwS). However, [...] Read more