Cancer Genetics

Given the promise and potential of genomic medicine, cancer genetics is a major focus of research at the Greehey Children’s Cancer Research Institute. Cancer development involves a complex series of molecular events, including mutations in proto-oncogenes, tumor suppressor genes, and other genes that regulate cell proliferation, cell cycle control, and cell death. These mutations enable cells to generate their own growth signals, resist growth-inhibitory signals, evade apoptosis, develop blood vessels, and proliferate uncontrollably. The completion of the human genome sequence, advancements in functional genomics and proteomics, and the use of genetically engineered mice have ushered in a new era of understanding the fundamental mechanisms of carcinogenesis.

The aim of the cancer genetics and molecular oncogenesis programs at Greehey CCRI is to identify and characterize the genes, gene products, and pathways involved in pediatric cancers. We recognize that insights gained from pediatric cancer models are relevant to cancer research as a whole. We expect that at least half of the new recruits to Greehey CCRI will be researchers specializing in cancer genetics and molecular oncogenesis.