The Computational Biology and Bioinformatics Initiative (CBBI) provides computational infrastructure, bioinformatics expertise, and interdisciplinary research to manage, distribute complex data sets, and develop and perform bioinformatics tasks and statistical analysis areas of genomics and systems biology. The CBBI aims to establish Greehey CCRI, as well as UT Health San Antonio, and its researchers as competitive leaders in the application of new biomedical technologies and computational methods to a variety of biomedical studies. With access to faculty members from the Department of Epidemiology and Biostatistics (DEB), The CBBI also provides a wide range of biostatistical assistance. The support includes, but is not limited to:
- Data analysis and microarray data quality control for microarray-based, genome-wide profiling experiment;
- Common genomic sequence-based bioinformatics tasks, such as sequence-alignment and genomic level annotation;
- Assistance to investigators with study planning, genomic-based experiment design, sample size, and power analyses;
- Development of data analysis tools that will allow investigators to generate and validate new hypotheses based on the integration of genomic and clinical data;
- Support for data resources, tools, and protocols to enable the investigators to share and apply genomic data to basic and translational research. Support for clinical informatics resources, including database design and application development expertise; and
- Other computational needs for basic/laboratory science, translational research, clinical-, and population-based research, including biomedical image analysis.
The CBBI, directed by Dr. Yidong Chen, is an integral part of the Greehey CCRI mission. By providing access to the expertise in data-driven and model-based computational research for investigators at Greehey CCRI, the CBBI opens new areas of research, enhances the quality and consistency of high-throughput data analysis, and improves the ability of UT Health San Antonio to support research in this genomic and systems biology era.
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The Greehey Children’s Cancer Research Institute is home to the Computational Biology and Bioinformatics Initiative (CBBI). The services of this initiative are available for researchers both inside and outside the Institute, the University, other academic institutions, and the biotechnology and pharmaceutical industries.