A GCCRI-based Xenograft and Cell Lines Core provide preclinical testing of chemotherapeutics and combinations in mouse models. This Core is available to the UT Health San Antonio research community, pharmaceutical companies, and any lab interested in conducting animal research. The methods used for performing testing and analysis of the data were established in PPTP (Establishment of human tumor xenografts in immunodeficient mice. Morton CL, Houghton PJ., Nat Protoc. 2007;2(2):247-50; Molecular characterization of the pediatric preclinical testing panel. Neale G, Su X, Morton CL, Phelps D, Gorlick R, et al. Clin Cancer Res. 2008 Jul 5;14(14):4572-83).
The team is highly skilled in vivo studies, including dose-response, toxicity testing, single-agent, combination efficacy testing, and pharmacodynamic studies. We have developed a biobank of a broad range of solid pediatric tumor xenograft models, including patient- and cell-derived models. For most of these, we also carry matching cell lines.
The Xenograft and Cell Lines Core, directed by Dr. Anna Rogojina, is integral to the Greehey CCRI vision of developing better therapies for cancer children.