Journal of Clinical Investigation: Efficacy and safety of a therapeutic humanized FSH–blocking antibody in obesity and Alzheimer’s disease models (Gupta)

July 30, 2025

 Anusha R. Pallapati,1 Funda Korkmaz,1 Satish Rojekar,1 Steven Sims,1 Anurag Misra,2 Judit Gimenez–Roig,1 Aishwarya Gangadhar,1 Victoria Laurencin,1 Anissa Gumerova,1 Uliana Cheliadinova,1 Farhath Sultana,1 Darya Vasilyeva,1 Liam Cullen,1 Jonathan Schuermann,3 Jazz Munitz,4 Hasni Kannangara,1 Surabhi Parte,1 Georgii Pevnev,1 Guzel Burganova,1 Zehra Tumoglu,1 Ronit Witztum,1 Soleil Wizman,1 Natan Kramskiy,1 Liah Igel,1 Fazilet Sen,1 Anna Ranzenigo,4 Anne Macdonald,1 Susan Hutchison,1 Abraham J.P. Teunissen,4 Heather Burkart,5 Mansi Saxena,1 Yelena Ginzburg,1 Ki Goosens,1 Weibin Zhou,1 Vitaly Ryu,1 Ofer Moldavski,1 Orly Barak,1 Michael Pazianas,1 John Caminis,1 Shalender Bhasin,6 Richard Fitzgerald,7 Se-Min Kim,1 Matthew Quinn,5 Shozeb Haider,8 Susan Appt,5 Tal Frolinger,1 Clifford J. Rosen,9 Daria Lizneva,1 Yogesh K. Gupta,2 Tony Yuen,1 and Mone [...]

Computational & Structural Biotechnology: Cell type prediction with neighborhood-enhanced cellular embedding using deep learning on hematoxylin and eosin-stained images (Chen Lab)

July 30, 2025

 Nam Nhut Phana ∙ Hanzhou Wanga ∙ Tapsya Nayaka ∙ Zhenqing Yea ∙ Yu-Chiao Chiub,c ∙ Yufang Jind ∙ Yufei Huangc,e,f ∙ Yidong Chena,g cheny8@uthscsa.edu  Abstract Purpose This study aimed to predict the cell types that infiltrate the tumor microenvironment using hematoxylin and eosin-stained images from colon cancer and breast cancer samples. Methods Two datasets, one focused on colon cancer and the other on breast cancer, were used to develop deep learning models. Cell segmentation was performed using [...]

Cell Reports: IGSF10 is a RET antagonist regulating Ewing sarcoma growth and GnRH neuron migration (Chen, Houghton, & Shiio Lab)

July 24, 2025

 Panneerselvam Jayabal1 ∙ Xiuye Ma1 ∙ Maleeha Akram2 ∙ Hannah Bow2 ∙ Pranay Mandal2 ∙ Naira Mansano2 ∙ Yidong Chen1,3,4 ∙ Susan T. Weintraub4,5 ∙ Peter J. Houghton1,4,6 ∙ Susan Wray2 ∙ Yuzuru Shiio Highlights Ewing sarcoma depends on IGSF10, which inhibits the RET receptor tyrosine kinase IGSF10 assembles an inhibitory RET-GAS1 complex and suppresses cdc42 The IGSF10-RET-GAS1-cdc42 pathway regulates the migration of GnRH neurons IGSF10 mutants linked to delayed puberty are defective in RET-cdc42 regulation Summary RET is a receptor tyrosine kinase that plays important [...]

BioRxiv: Robust statistical assessment of Oncogenotype to Organotropism translation in xenografted zebrafish (Kurmasheva, et al)

June 24, 2025

 Abstract Organotropism results from the functional versatility of metastatic cancer cells to survive and proliferate in diverse microenvironments. This adaptivity can originate in clonal variation of the spreading tumor and is often empowered by epigenetic and molecular reprogramming of cell regulatory circuits. Related to organotropic colonization of metastatic sites are environmentally-sensitive, differential responses of cancer [...]

Advanced Science: Biosecurity Primitive: Polymerase X-based Genetic Physical Unclonable Functions (Pertsemlidis)

June 18, 2025

 Zikun Zhou, Taek Kang, Jie Chen, Yesh Doctor, Jocelyn G Camposagrado, Yiorgos Makris, Alexander Pertsemlidis, Leonidas Bleris Abstract A Physical Unclonable Function (PUF) is a security primitive that exploits inherent variations in manufacturing protocols to generate unique, random-like identifiers. These identifiers are used for authentication and encryption purposes in hardware security applications in the semiconductor industry. Inspired by the success of silicon [...]

BioMolecular NMR Assignments: The 1H, 15N and 13C backbone resonance assignments of the N-terminal (1-149) domain of Serpine mRNA Binding Protein 1 (SERBP1) (Libich Lab)

May 30, 2025

 Antoine Baudin, Hoang H. Dinh, Xiaoping Xu & David S. Libich Abstract Serpine mRNA-Binding Protein 1 (SERBP1) is an RNA-binding protein implicated in diverse cellular functions, including translational regulation, tumor progression, and stress response. It interacts with ribosomal subunits, RNA, and proteins involved in stress granules, contributing to processes such as phase separation and epigenetic regulation. [...]

PNAS: Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain (Libich & Bishop Labs)

May 16, 2025

 Emily E. Selig  Erich J. Sohn  Aiola Stoja, Alma K. Moreno-Romero, Shivani Akula, Xiaoping Xu, Alexander J. R. Bishop, and David S. Libich Significance The oncogenic fusion protein, EWS::FLI1, responsible for more than 85% of Ewing sarcoma tumors, combines the transactivation domain from EWS and the DNA-binding domain (DBD) from Friend leukemia integration 1 (FLI1). The fusion impacts the function of wild-type EWS and drives oncogenesis via [...]

Cell Reports: Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation (Sung, Libich Labs)

May 7, 2025

 Francisco E. Neal1,2 ∙ Wenjing Li1 ∙ Mollie E. Uhrig3,4 ∙ Jeffrey N. Katz1,2 ∙ Shahrez Syed1,2 ∙ Neelam Sharma3 ∙ Arijit Dutta1,2,8 ∙ Sandeep Burma1,5 ∙ Robert Hromas6 ∙ Alexander V. Mazin1 ∙ Eloise Dray1 ∙ David S. Libich1,2 ∙ Shaun K. Olsen1,2 ∙ Elizabeth V. Wasmuth1,2 ∙ Weixing Zhao1,2 ∙ Claus S. Sørensen7 Highlights BRCA2 OB-fold DNA-binding domain has specificity for ssDNA BRCA2 C-terminal DNA-binding domain has specificity for dsDNA OB-fold DNA-binding domain is needed for DNA repair and replication fork protection C-terminal DNA-binding domain functions primarily in replication fork protection Summary Homologous recombination (HR) removes DNA double-strand breaks [...]

Trends in Molecular Medicine: The RB protein: more than a sentry of cell cycle entry (Sung Lab)

May 1, 2025

 Pulari U. Thangavelu1,11 ∙ Cheng-Yu Lin1,11 ∙ Farzaneh Forouz2 ∙ Kozo Tanaka3 ∙ Eloïse Dray4,5,6 ∙ Pascal H.G. Duijf7,8,9,10 pascal.duijf@unisa.edu.au Highlights The retinoblastoma protein (RB) signal transduction pathway suppresses tumor development and is impaired in most cancers. RB pathway disruption in tumors promotes a broad range of malignant properties, such as cancer-associated blood vessel formation, metastasis, inflammation, immune evasion, cell survival, and metabolic reprogramming, as well as genomic instability. Impaired RB pathway [...]