Molecular & Cellular Oncology: The inheritance of centromere identity

Published On: June 30, 2016
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Yohei Niikura,Risa Kitagawa & Katsumi Kitagawa

ABSTRACT

CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for the epigenetic mark of centromere identity.

KEYWORDS: CENP-A, centromere identity, centromere, CUL4A-RBX1-COPS8 E3 ligase, dimerization, epigenetics, kinetochore, lysine 124 (K124), monoubiquitin-fused CENP-A mutant, neocentromere, ubiquitylation
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