Molecular & Cellular Oncology: The inheritance of centromere identity

Yohei Niikura,Risa Kitagawa & Katsumi Kitagawa

ABSTRACT

CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for the epigenetic mark of centromere identity.

KEYWORDS: CENP-A, centromere identity, centromere, CUL4A-RBX1-COPS8 E3 ligase, dimerization, epigenetics, kinetochore, lysine 124 (K124), monoubiquitin-fused CENP-A mutant, neocentromere, ubiquitylation

Since 2004, UT Health San Antonio, Greehey Children’s Cancer Research Institute’s (Greehey CCRI) mission has been to advance scientific knowledge relevant to childhood cancer, contribute to the understanding of its causes, and accelerate the translation of knowledge into novel therapies. Through the discovery, development, and dissemination of new scientific knowledge, Greehey CCRI strives to have a national and global impact on childhood cancer. Our mission consists of three key areas: research, clinical, and education.

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